Eccrine Spiradenoma in a Zosteriform Distribution: Presentation of a Case

Alfonso-Trujillo, Israel; Arteaga-Hernández, E.; Pérez-Suárez, J.C.

doi:10.1016/s1578-2190(09)70134-9

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Zosteriform presentation of papules and plaques have been reported in several kinds of skin diseases, such as sporotrichosis, leishmaniasis, seborrheic keratosis, palisaded-encapsulated neuroma, eccrine spiradenoma, cutaneous leiomyoma, zosteriform cutaneous metastases from malignant tumor, and so on. [4567891011]…”

Section: Discussionmentioning

confidence: 99%

Zosteriform lymphangitic metastases of eccrine porocarcinoma

Zhang

et al. 2019

Indian J Dermatol

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Eccrine porocarcinoma (EPC) is a rare malignant neoplasm which originates from the intraepidermal portion of eccrine sweat glands or acrosyringium. Here, we report a unique case of cutaneous metastases of EPC presenting with an erosive plaque on the left thumb and multiple nodules on left forearm. The histopathological examination of the wrist lesion revealed islands of basaloid tumor cells with eosinophilic cytoplasm, downward infiltrating growths, ductal differentiation, and intracytoplasmic lumen formations and focally connected to the epidermis. Acrosyringeal differentiation was confirmed by positive immunohistochemical staining using antibodies to carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA) in some of porocarcinoma cells. Lymphatic embolization was shown by immunostaining of podoplanin. To the best of our knowledge, this is the first reported EPC case with a primary lesion on the left thumb and zosteriform growth pattern of lymphangitic metastases on left forearm. Our case highlights the diagnostic challenges and reveals lymphangitic metastasis mode of EPC.

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Section: Discussionmentioning

confidence: 99%

Zosteriform lymphangitic metastases of eccrine porocarcinoma

Zhang

et al. 2019

Indian J Dermatol

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Heterozygous cylindromatosis gene mutation c.1628_1629delCT in a family with brook-spiegler syndrome

et al. 2016

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Brooke–Spiegler Syndrome (BSS) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face, mainly trichoepitheliomas, cylindromas, and spiradenomas. It has also been associated with salivary glands neoplasms. It is due to mutations in the tumor suppressor gene cylindromatosis (CYLD gene) localized on chromosome 16q12−q13. Around 93 mutations have been described. The study of CYLD gene in patients and their relatives is of vital importance to establish the molecular diagnosis and offer appropriate genetic counseling. There is a low risk of malignancy and patients require long-term follow-up. A case of BSS in a family is described. The existence of the genetic mutation at the CYLD gene c. 1628_1629delCT in three of the women affected was demonstrated. This mutation has only been described once in a previous study.

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