Eccrine sweat gland in Macaca mulatta: physiology, histochemistry, and distribution.

Johnson, Gina; Elizondo, R. S.

doi:10.1152/jappl.1974.37.6.814

Cited by 20 publications

(20 citation statements)

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“…Freedman and colleagues found that sweating onset in humans is at a core temperature of 35.51C and a skin temperature of 371C. In rhesus monkeys, sweating starts at a rectal temperature of 37.71C and a skin temperature of 35.41C (Johnson and Elizondo, 1974) but this threshold is markedly increased by (7)MDMA (Freedman et al, 2005); the skin temperature appeared to stabilize immediately after the onset of sweating. In combination with the nearly identical magnitude of the MDMA effect on skin vs core temperature, this suggests that cutaneous vascular changes may contribute little to thermoregulation under these conditions.…”

Section: Discussionmentioning

confidence: 99%

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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The ambient temperature (T A ) under which rodents are exposed to (7)3,4-methylenedioxymethamphetamine (MDMA) affects the direction and magnitude of the body temperature response, and the degree of hypo/hyperthermia generated in subjects can modify the severity of lasting brain changes in 'neurotoxicity' models. The thermoregulatory effects of MDMA have not been well described in nonhuman primates and it is unknown if T A has the potential to affect acute hyperthermia and therefore other lasting consequences of MDMA. The objective of this study was to determine if the temperature alteration produced by MDMA in nonhuman primates depends on T A as it does in rats and mice. Body temperature and spontaneous home cage activity were monitored continuously in six male rhesus monkeys via radiotelemetry. The subjects were challenged intramuscularly with 0.56-2.4 mg/kg (7)MDMA under each of three T A conditions (18, 24, and 301C) in a randomized order. The temperature was significantly elevated following injection with all doses of MDMA under each ambient temperature. The magnitude of mean temperature change was B11C in most conditions suggesting a closely controlled thermoregulatory response in monkeys across a range of doses and ambient temperatures. Activity levels were generally suppressed by MDMA; however, a 50% increase over vehicle was observed after 0.56 MDMA under the 301C condition. It is concluded that MDMA produces a similar degree of hyperthermia in rhesus monkeys across a range of T A conditions that result in hypothermia or exaggerated hyperthermia in rodents. Monkey temperature responses to MDMA appear to be more similar to humans than to rodents and therefore the monkey may offer an improved model of effects related to MDMA-induced hyperthermia.

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Section: Discussionmentioning

confidence: 99%

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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“…Different types of eccrine sweat glands are found in many mammals and have been described in detail [Schaffer, 1940;Terzakis, 1964;Johnson and Elizondo, 1974;Kurosumi et al, 1982;Tsukise et al, 1988;Marcucci and Castano, 1990;Meyer and Tsukise, 1995]. A careful study of the Procavia skin glands is lacking, and in order to correlate glandular morphology with the hyrax mode of life we investigated these skin glands.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Eccrine Glands of the Foot Pads of the Rock Hyrax (<i>Procavia capensis</i>, Hyracoidea, Mammalia)

Stumpf

Welsch

2002

Cells Tissues Organs

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In order to find correlations between skin gland morphology and specific ethological features, the cutaneous glands of the foot pads of Procavia capensis were studied by histological and various histochemical methods and by electron microscopy. In the foot pads, abundant specific eccrine skin glands occur, which consist of coiled tubular secretory portions and coiled ducts. The wall of the secretory part is composed of cuboidal glandular cells and myoepithelial cells. Among the glandular cells two types occur: clear and dark cells. Clear cells have numerous mitochondria and form a basal labyrinth, indicating fluid transport. Dark cells, which stain strongly with periodic acid-Schiff, contain a highly developed perinuclear Golgi apparatus, large amounts of rough endoplasmic reticulum and many secretory granules indicating production of glycoproteins. Cytokeratin (CK) 19 was found in secretory compartments and ducts, CK14 only in duct cells. Single cells of the secretory coils and ducts may be stained with antibodies against antimicrobial peptides. Some glandular cells contain proliferating cell nuclear antigen-positive nuclei especially in the ducts indicating an increased cell proliferation. Terminal transferase (TdT)-mediated d-UTP nick-end labeling-positive nuclei can be detected predominantly in the secretory coils and rarely in the transitional portions between ducts and end pieces. We suppose that proliferating cells migrate from the ducts to the secretory coils. The secretory product of the eccrine cutaneous glands seems to improve the traction between the foot pads of these animals and the steep and smooth rock formations among which they live.

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“…As has been demonstrated previously (13,18), the maximal sweat rate capacity of the rhesus monkey is less than that of humans; thus their ability to thermoregulate under stressful environmental conditions is not as effective. This predisposition was demonstrated in the 35 *C trial where the monkeys stored heat at a prohibitively high rate during 30 min of exercise (Fig.…”

Section: Discussionmentioning

confidence: 81%

“…Resting and exercise studies have primarily concentrated on mechanisms of thermal balance (13,18,19,28), metabolic rate (19), and manipulation of central mechanisms of thermoregulation (1, 14,25). These studies have demonstrated many similarities between the thermoregulatory systems of rhesus and human subjects.…”

Section: Introductionmentioning

confidence: 99%

The Metabolic and Thermoregulatory Responses of Rhesus Monkeys to Combined Exercise and Environmental Heat Load

Heaps¹,

Constable²

1993

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Eccrine sweat gland in Macaca mulatta: physiology, histochemistry, and distribution.

Cited by 20 publications

References 0 publications

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Cutaneous Eccrine Glands of the Foot Pads of the Rock Hyrax (<i>Procavia capensis</i>, Hyracoidea, Mammalia)

The Metabolic and Thermoregulatory Responses of Rhesus Monkeys to Combined Exercise and Environmental Heat Load

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