Ecdysones and synthetic analogs: Molting hormone activity and inhibitive effects on insect growth, metamorphosis and reproduction

RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on Larval Lepidoptera

“…RH 5849 controls dipteran larvae (both houseflies and mosquitoes) and certain coleopteran larvae and has been shown to inhibit ovariole development in all three orders (11). This latter activity is consistent with its putative ecdysonergic mechanism of action (12). The 1,2-diacyl-1-alkylhydrazines are thus a novel class of "ecdysonoids" and are representative members of the third generation insecticides having their genesis in insect hormones (13).…”

Postingestive Effects of Phytochemicals On Insects: On Paracelsus and Plant Products

“…Direct injection of bracken extract, however, promoted early molting. Robbins et al (1970) administered ecdysterone and ponasterone A in artificial diet to Musca domestica larvae and adults and observed a significant reduction in emergence and in ovarian development. Since house flies are not herbivorous, the ecological significance of these results is unclear.…”

Triterpenes and Steroids

“…However, to the larvae of the cecropia silkwonn, Hyalophora cecropia, ponasterone A (42) was highly active when incorporated into artificial diets. Toxicity (interfering with development and reproduction) has been shown in other insects as well (Camps, 1991;Robbins et al, 1970).…”