Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats

Wu, Jiming; Gao, Le; Shang, Lei; Wang, Guihua; Wei, Nana; Chu, Tiantian; Chen, Suping; Zhang, Yujun; Huang, Jian; Wang, Jinhui; Lin, Rui‐Chao

doi:10.1016/j.fitote.2017.03.015

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…( Compositae )) is a perennial herb that grows in the Altai Mountains, Western and Eastern Siberia and Central Asia. In medicine, rhizomes with rhaponticum roots are used as a general tonic and adaptogenic drug [ 97 , 98 , 99 ]. It is widely used as a dietary supplement and is valued as a rich natural source of ecdysteroids, which are present in all parts of the plant [ 97 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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“…The intake of Rhaponticum carthamoides is not associated with serious side effects [ 19 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ].…”

Section: Resultsmentioning

confidence: 99%

“…The intake of Rhaponticum carthamoides is not associated with serious side effects [19,[59][60][61][62][63][64][65][66][67][68][69][70][71][72].…”

Section: Rhaponticum Carthamoides Extract Increased Muscle Protein Synthesis the Combination Of Rhaponticum Carthamoides Andmentioning

confidence: 99%

Plant Adaptogens—History and Future Perspectives

et al. 2021

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Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body’s stability against physical loads without increasing oxygen consumption. Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis are considered to be naturally occurring adaptogens and, in particular, plant adaptogens. The aim of this study is to evaluate the use of plant adaptogens in the past and now, as well as to outline the prospects of their future applications. The use of natural adaptogens by humans has a rich history—they are used in recovery from illness, physical weakness, memory impairment, and other conditions. About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body’s resistance to stress and to improve physical endurance. Although now many people take plant adaptogens, the clinical trials on human are limited. The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

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“…Restricting the hyperactivation of stress-promoting systems under the influence of R. uniflorum and S. centauroides extracts also seems to be connected with the GABA-mimetic effects of ecdysteroids, which were verified experimentally with the use of a competitive antagonist of GABA-A receptors, bicuculline. Reportedly, 20-hydroxyecdysone, a dominant compound of R. uniflorum and S. centauroides extracts, has an affinity for GABA-A-receptors, promoting GABA-ergic currents in experiments on rat neuron cultures [26].…”

Section: Discussionmentioning

confidence: 99%

“…Besides their antioxidant activity is due to the high content of ecdysteroids, the chief of which is 20hydroxyecdysone (content: 17.83 ± 0.35 and 27.43 ± 0.55 mg/g). The given compounds reportedly stimulate ATP synthesis, limit the generation of free radicals, promote the activation of the antioxidant protection of the body and inhibit free radical oxidation processes and the glutamate-calcium cascade that induces the development of stress-induced injuries [26,29,30].…”

Section: Discussionmentioning

confidence: 99%

Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

et al. 2021

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In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as Rhaponticum uniflorum (L.) DC. and Serratula centauroides L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of R. uniflorum and S. centauroides extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, R. uniflorum and S. centauroides extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, R. uniflorum and S. centauroides extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.

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Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats

Cited by 12 publications

References 29 publications

Medicinal Plants to Strengthen Immunity during a Pandemic

Medicinal Plants to Strengthen Immunity during a Pandemic

Plant Adaptogens—History and Future Perspectives

Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

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