ECG Diagnosis: Hypokalemia

Levis, Joel T.

doi:10.7812/tpp/12-015

Cited by 30 publications

(18 citation statements)

References 2 publications

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“…Hypokalaemia is often associated with hypomagnesaemia, which increases the risk of malignant ventricular arrhythmias. 84 Hypo kalaemia has been attributed to excessive glucocorticoids saturating 11β-HSD2, leading to inappropriate activation of the mineralocorticoid receptor. 85 Worsening of hypokalaemia has been reported with adrenal-directed drugs that can increase cortisol precursors with mineralocorticoid activity, and also with mifepristone.…”

Section: Hypokalaemiamentioning

confidence: 99%

Complications of Cushing's syndrome: state of the art

Pivonello

Isidori

Martino

et al. 2016

The Lancet Diabetes & Endocrinology

457

439

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Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities. These clinical complications include metabolic syndrome, consisting of systemic arterial hypertension, visceral obesity, impairment of glucose metabolism, and dyslipidaemia; musculoskeletal disorders, such as myopathy, osteoporosis, and skeletal fractures; neuropsychiatric disorders, such as impairment of cognitive function, depression, or mania; impairment of reproductive and sexual function; and dermatological manifestations, mainly represented by acne, hirsutism, and alopecia. Hypertension in patients with Cushing's syndrome has a multifactorial pathogenesis and contributes to the increased risk for myocardial infarction, cardiac failure, or stroke, which are the most common causes of death; risks of these outcomes are exacerbated by a prothrombotic diathesis and hypokalaemia. Neuropsychiatric disorders can be responsible for suicide. Immune disorders are common; immunosuppression during active disease causes susceptibility to infections, possibly complicated by sepsis, an important cause of death, whereas immune rebound after disease remission can exacerbate underlying autoimmune diseases. Prompt treatment of cortisol excess and specific treatments of comorbidities are crucial to prevent serious clinical complications and reduce the mortality associated with Cushing's syndrome.

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Section: Hypokalaemiamentioning

confidence: 99%

Complications of Cushing's syndrome: state of the art

Pivonello

Isidori

Martino

et al. 2016

The Lancet Diabetes & Endocrinology

457

439

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“…Tachyarrhythmia and rarely atrioventricular block may evolve. The rate of the decrease in serum potassium levels is more important than the absolute level of serum potassium, because rapid onset hypokalaemia may lead to serious symptoms, including life‐threatening heart rhythm abnormalities .…”

Section: Signs and Symptoms Of Hypokalaemiamentioning

confidence: 99%

Current views on the diagnosis and management of hypokalaemia in children

2016

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“…It was determined that the patient had baseline hypokalemia as a function of alcohol abuse, exacerbated by self overmedication with hydrochlorothiazide for elevated blood pressure readings at home. The diagnosis was suspected when an electrocardiogram was obtained demonstrating a pseudo-prolonged QT interval with ST depression, consistent with T-U wave fusion and a QU interval with an absent T wave 1. The patient received oral and intravenous potassium and magnesium supplementation with resolution of symptoms.…”

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confidence: 99%

A Case of Thiazide-induced Hypokalemic Paralysis

Schell

Pathman

Pescatore

et al. 2019

Clinical Practice and Cases in Emergency Medicine

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We describe the case of a patient presenting with odd neurologic symptoms initially thought to represent somatization who was found to have critical hypokalemia manifesting as hypokalemic non-periodic paralysis. It was determined that the patient had baseline hypokalemia as a function of alcohol abuse, exacerbated by self overmedication with hydrochlorothiazide for elevated blood pressure readings at home. The diagnosis was suspected when an electrocardiogram was obtained demonstrating a pseudo-prolonged QT interval with ST depression, consistent with T-U wave fusion and a QU interval with an absent T wave.1 The patient received oral and intravenous potassium and magnesium supplementation with resolution of symptoms.

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ECG Diagnosis: Hypokalemia

Cited by 30 publications

References 2 publications

Complications of Cushing's syndrome: state of the art

Complications of Cushing's syndrome: state of the art

Current views on the diagnosis and management of hypokalaemia in children

A Case of Thiazide-induced Hypokalemic Paralysis

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