ECG Markers of Acute Melatonin Treatment in a Porcine Model of Acute Myocardial Ischemia

Bernikova, Olesya; Tsvetkova, Alena S.; Ovechkin, Alexey; Demidova, Marina M.; Azarov, Jan E.; Platonov, Pyotr G.

doi:10.3390/ijms231911800

Cited by 3 publications

(4 citation statements)

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“…A similar effect of melatonin has been demonstrated in a chronic model of melatonin treatment, where melatonin modified both depolarization and repolarization processes, but only the depolarization changes were associated with the antiarrhythmic action of melatonin, while the effect on repolarization (but not on depolarization) correlated with antioxidant activity [27]. Also, the data obtained in the present study correspond to the findings in the porcine model of acute ischemia with the application of melatonin [31,32]. Collectively, the present findings suggest that the antiarrhythmic effects of melatonin were related to the changes in the depolarization process.…”

Section: Discussionsupporting

confidence: 88%

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Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts

Durkina,

Szeiffova Bacova,

Bernikova

et al. 2023

IJMS

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Melatonin has been reported to cause myocardial electrophysiological changes and prevent ventricular tachycardia or fibrillation (VT/VF) in ischemia and reperfusion. We sought to identify electrophysiological targets responsible for the melatonin antiarrhythmic action and to explore whether melatonin receptor-dependent pathways or its antioxidative properties are essential for these effects. Ischemia was induced in anesthetized rats given a placebo, melatonin, and/or luzindole (MT1/MT2 melatonin receptor blocker), and epicardial mapping with reperfusion VT/VFs assessment was performed. The oxidative stress assessment and Western blotting analysis were performed in the explanted hearts. Transmembrane potentials and ionic currents were recorded in cardiomyocytes with melatonin and/or luzindole application. Melatonin reduced reperfusion VT/VF incidence associated with local activation time in logistic regression analysis. Melatonin prevented ischemia-related conduction slowing and did not change the total connexin43 (Cx43) level or oxidative stress markers, but it increased the content of a phosphorylated Cx43 variant (P-Cx43368). Luzindole abolished the melatonin antiarrhythmic effect, slowed conduction, decreased total Cx43, protein kinase Cε and P-Cx43368 levels, and the IK1 current, and caused resting membrane potential (RMP) depolarization. Neither melatonin nor luzindole modified INa current. Thus, the antiarrhythmic effect of melatonin was mediated by the receptor-dependent enhancement of impulse conduction, which was associated with Cx43 phosphorylation and maintaining the RMP level.

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Section: Discussionsupporting

confidence: 88%

“…Acute effects of melatonin application were studied in anesthetized pigs [31,32] and ex vivo in perfused rat hearts [17]. These investigations demonstrated that melatonin reduced ventricular tachycardia and/or ventricular fibrillation (VT/VF) incidence.…”

Section: Introductionmentioning

confidence: 99%

Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts

Durkina,

Szeiffova Bacova,

Bernikova

et al. 2023

IJMS

Self Cite

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“…Tp-e can be measured in a single lead or from the earliest Tpeak among all leads to the latest Tend throughout all leads. The second method is often used in research studies [ 23 – 25 ]. Moreover, the measurement of Tp-e in multiple leads is preferred to measurement in single lead because it allows the calculation of Tp-e dispersion, which is a difference between the highest and the lowest value of Tp-e in all leads [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

Dykiert,

Florek,

Kraik

et al. 2024

Scientifica

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Globally, cardiovascular diseases are still the leading cause of death. Numerous methods are used to diagnose cardiovascular pathologies; there is still a place for straightforward and noninvasive techniques, such as electrocardiogram (ECG). Depolarization and repolarization parameters, including QT interval and its derivatives, are well studied. However, the Tpeak‐Tend interval is a novel and promising ECG marker with growing evidence for its potential role in predicting malignant arrhythmias. In this review, we discuss the association between the Tpeak‐Tend interval and several cardiovascular diseases, including long QT syndrome, cardiomyopathies, heart failure, myocardial infarction, and obesity, which constitutes one of the risk factors for cardiovascular diseases.

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“…As an ECG parameter, QRS was considered a predictor of left ventricular systolic dysfunction after a first STEMI by Fabiszak et al ( 29 ). Bernikova et al reported that the QRS duration prolonged after LAD occlusion ( 30 ). The QRS duration also had a special prognostic significance in NSTEMI patients ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

The ratio of QRS/RV6-V1: a new electrocardiographic predictor of short- and long-term adverse clinical outcomes in patients with acute myocardial infarction combined with new-onset right bundle branch block

Cui

et al. 2023

Front. Cardiovasc. Med.

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BackgroundA few studies have focused on electrocardiography (ECG) parameters correlating with clinical prognosis in patients with acute myocardial infarction (AMI) combined with new-onset right bundle branch block (RBBB).ObjectiveTo assess the prognostic value of a new ECG parameter, namely, the ratio of QRS duration/RV6-V1 interval (QRS/RV6-V1), in patients with AMI combined with new-onset RBBB.Materials and methodsA total of 272 AMI patients combined with new-onset RBBB who received primary percutaneous coronary intervention (P-PCI) were retrospectively enrolled in the study. First, the patients were divided into survival group and non-survival group. Demographic, angiographic, and ECG characteristics were compared between the two groups. Receiver operating characteristic (ROC) curve was used to screen the best ECG parameter for predicting 1-year mortality. Second, the ratio of QRS/RV6-V1, a continuous variable, was converted to the high ratio group and low ratio group according to the optimal cutoff value point determined by the X-tile software. We compared the patient’s demographic, angiographic, and ECG characteristics, in-hospital major adverse cardiovascular events (MACE), and 1-year mortality between the two groups. Multivariate logistic and Cox regressions were used to evaluate whether the ratio of QRS/RV6-V1 was an independent prognostic factor of in-hospital MACE and 1-year mortality.ResultsThe ROC curve showed that the ratio of QRS/RV6-V1 had a higher value for predicting in-hospital MACE and 1-year mortality than the QRS duration, RV6-V1 interval, and RV1 interval. The patients in the high ratio group had significantly higher CK-MB peak and Killip class, lower ejection fraction (EF%), higher ratio of the left anterior (LAD) descending artery as infarct-related artery (IRA), and longer total ischemia time (TIT) than those in the low ratio group. The QRS duration was wider in the high ratio group than that in the low ratio group, whereas RV6-V1 was narrower in the high ratio group compared with that in the low ratio group. The in-hospital MACE rate (93.3% vs. 31.0%, p < 0.001) and 1-year mortality rate (86.7% vs. 13.2%, p < 0.001) in the high ratio group were higher than those in the low ratio group. The higher ratio of QRS/RV6-V1 was an independent predictor of in-hospital MACE (odds ratio, 8.55; 95% CI, 1.40–52.37; p = 0.02) after adjusting other confounders. Cox regression showed that the higher ratio of QRS/RV6-V1 predicted higher 1-year mortality of the patients with AMI combined with new-onset RBBB [hazard ratios (HR), 12.4; 95% CI, 7.26–21.22); p < 0.001] than the lower ratio of QRS/RV6-V1, and the HR still stayed at 2.21 even after a multivariable adjustment (HR, 2.21; 95% CI, 1.05–4.64); p = 0.037).ConclusionAccording to the results of our study, the high ratio of QRS/RV6-V1 (>3.0) was a valuable predictor of short- and long-term adverse clinical outcomes in AMI patients combined with new-onset RBBB. The implications of the high ratio of QRS/RV6-V1 were severe ischemia and pseudo synchronization between bi-ventricle.

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ECG Markers of Acute Melatonin Treatment in a Porcine Model of Acute Myocardial Ischemia

Cited by 3 publications

References 43 publications

Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts

Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

The ratio of QRS/RV6-V1: a new electrocardiographic predictor of short- and long-term adverse clinical outcomes in patients with acute myocardial infarction combined with new-onset right bundle branch block

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