Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

Ren, Wenkai; Ban, Junfeng; Xia, Yaoyao; Zhou, Fang; Cao, Yuan; Jia, Huanhuan; Jiang, Mingmin; Liang, Maojin; Li, Zhaodong; Yuan, Y; Yin, Yulong; Wu, Hong Gyun

doi:10.1016/j.xinn.2023.100391

Cited by 15 publications

(9 citation statements)

References 51 publications

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“…12 A novel homogeneous polysaccharide from E. purpurea (EPPA) is under study and its oral use could be a strategy to tackle tumors by tailoring M1 macrophage function. 13 Patients with Recurrent Herpes Labialis were studied and used a liquid form administered 3x to the subjects participating in the study and the response of Tregs cells immunosuppressants (CD4 +CD25+) decreased significantly, giving rise to lymphocyte redistribution. 14 A recent review cross-referencing information on preventive use and as antiviral agent for the treatment of respiratory diseases caused by some already known variants of Sars Cov II, concluded that although more studies need to be carried out, it can be said that the preventive action in children up to 12 years old proved to be very effective.…”

Section: Phytosterols Participate In the Anti-inflammation Mechanism Andmentioning

confidence: 99%

Echinacea purpurea, a pathway to increased immunity

Ciaccio Vendola

2023

JSRT

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This work aims to return scientific interest to the valuable biochemical components found in Phytotherapy in times of exponential growth of viral propagation in the world. The topic addressed will be specifically the Echinacea Purpúrea plant, a member of the Compositae or Asteraceae family, which has been researched all over the world , may open up new possibilities for the treatment of oral and systemic diseases , using its own biochemistry as a stimulating factor to increase immunity. Recent studies in humans have shown actions of interest in the immune response with its use, both in aerial part and roots.

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Section: Phytosterols Participate In the Anti-inflammation Mechanism Andmentioning

confidence: 99%

Echinacea purpurea, a pathway to increased immunity

Ciaccio Vendola

2023

JSRT

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“…Polysaccharides with high viscosity can be used as a safe thickening agent in food processing (Wang, Yin, et al., 2020). Furthermore, polysaccharides derived from fungi and lactic acid bacteria also have been proven to have antitumor (Ren et al., 2021), antioxidant (Chen, Zeng, et al., 2021), hypoglycemic (Sun et al., 2023), immunomodulatory (Ren et al., 2023), and other biological activities (Pak et al., 2021). Concurrently, scientists have discovered that the bioactivities of polysaccharides are commonly influenced by various factors, such as the monosaccharides types, the mode of glycosidic linkage, anomeric carbon configuration, degree of polymerization, molecular sizes, chain conformation, and tertiary structures (Laffargue et al., 2023; Manjón et al., 2023).…”

Section: Introductionmentioning

confidence: 99%

“…Polysaccharides with high viscosity can be used as a safe thickening agent in food processing (Wang, Yin, et al, 2020). Furthermore, polysaccharides derived from fungi and lactic acid bacteria also have been proven to have antitumor (Ren et al, 2021), antioxidant (Chen, Zeng, et al, 2021), hypoglycemic (Sun et al, 2023), immunomodulatory (Ren et al, 2023), and other biological activities (Pak et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Exploring the partial degradation of polysaccharides: Structure, mechanism, bioactivities, and perspectives

Chen,

Wang,

Guo

et al. 2023

Comp Rev Food Sci Food Safe

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Polysaccharides are promising biomolecules with lowtoxicity and diverse bioactivities in food processing and clinical drug development. However, an essential prerequisite for their applications is the fine structure characterization. Due to the complexity of polysaccharide structure, partial degradation is a powerful tool for fine structure analysis, which can effectively provide valid information on the structure of backbone and branching glycosidic fragments of complex polysaccharides. This review aims to conclude current methods of partial degradation employed for polysaccharide structural characterization, discuss the molecular mechanisms, and describe the molecular structure and solution properties of degraded polysaccharides. In addition, the effects of polysaccharide degradation on the conformational relationships between the molecular structure and bioactivities, such as antioxidant, antitumor, and immunomodulatory activities, are also discussed. Finally, we summarize the prospects and current challenges for the partial degradation of polysaccharides. This review will be of great value for the scientific elucidation of polysaccharide fine structures and potential applications.

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“…After reviewing the specialist literature, it was discovered that the anti-inflammatory, antioxidant, antibacterial, antiviral, antitumoral, and antiosteoporotic effects, as well as the cannabinomimetic and immunomodulating capacity, had been wellresearched. According to the findings of these investigations, the active components in Echinacea purpurea (L.) Moench induce phagocytosis and create effective barriers against the spread of infectious and inflammatory processes [15][16][17][18][19][20][21][22][23][24]. Studies tended to place more emphasis on the consequences of internal usage than exterior use.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Bioactive Compounds from Echinacea purpurea (L.) Moench Leaves Extracts in Correlation with the Antimicrobial Activity and the In Vitro Wound Healing Potential

et al. 2023

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This study aimed at the relationship between antioxidant capacity, antimicrobial activity, and in vitro evaluation of the wound healing effect of the extract obtained from Echinaceae purpureae folium (EPF). This study’s objective was to assess the bioactive components (total phenol and flavonoid content) and antioxidant activity of EPF extracts using the DPPH test method. The antioxidant capacity and the quantities of the compounds with antioxidant capacity were evaluated by spectrophotometric methods. Antimicrobial activity has been investigated against various pathogenic microorganisms. The minimum inhibitory concentration was determined by the microdilution method. Additionally, our work used a scratch test to examine the in vitro wound healing effects of EPF extract on NHDF cells. Statistical analysis was used to quantify the rate of migration and proliferation of fibroblast cells within the wound. Microscope pictures of fibroblast cells exposed to various EPF extract dosages were processed to estimate the width of the wound, area of the wound, and cell density inside the wound. The study proved that there was a relationship between the antioxidant, antimicrobial, and wound healing ability of EPF extracts.

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Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

Cited by 15 publications

References 51 publications

Echinacea purpurea, a pathway to increased immunity

Echinacea purpurea, a pathway to increased immunity

Exploring the partial degradation of polysaccharides: Structure, mechanism, bioactivities, and perspectives

Determination of the Bioactive Compounds from Echinacea purpurea (L.) Moench Leaves Extracts in Correlation with the Antimicrobial Activity and the In Vitro Wound Healing Potential

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