Echinacoside, an Active Constituent of &lt;i&gt;Cistanche Herba&lt;/i&gt;, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway

Lu, Cheng Wei; Hsieh, Hsi‐Lung; Lin, Tzu-Yu; Hsieh, Ting Yang; Huang, Shu Kuei; Wang, Su‐Jane

doi:10.1248/bpb.b18-00407

Cited by 23 publications

(8 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, as a crucial active compound from CH, ECH plays a key role toward neuroprotective activity according to regulating multiple pharmacological mechanisms. ECH improves seizure‐like behavioral patterns by decreasing glutamate concentrations and inhibiting proinflammatory cytokine genes expression 124 . The antiepileptic effect of ECH may be also attributed to the simultaneous decreases of both glutamate release and blockage of abnormal firing synchronization in hippocampal pyramidal neurons 125 .…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Song

Zeng

Jiang

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Cistanches Herba (CH, Chinese name: Roucongrong), is a very precious, tonic Chinese medicine. Cistanche deserticola and Cistanche tubulosa are the two commonly used species and authenticated in Chinese Pharmacopoeia. Due to the parasitic nature of Cistanche plants, the wild source was once endangered and listed in the Appendix II of Convention on International Trade in Endangered Species of Wild Fauna and Flora. However, after continuously struggling in the past decades, CH has grown up to a big brand of Chinese medicine featured with the cultivation area as 1.26 million mu, the annual output as 6000 tons, and the related industrial output value as more than 20 billion China Yuan, attributing to large‐scale cultivation and in‐depth phytochemical and pharmacological investigations. Noteworthily, great achievements have reached concerning the research and development of relevant products, such as modern drugs, traditional Chinese medicine prescriptions, and dietary supplements. The current review summarizes the research progresses concerning the distribution and cultivation, phytochemistry, pharmacology, metabolism and product development of CH in the past decades, and the emerging challenges and developing prospects are discussed as well.

show abstract

Section: Pharmacological Activitiesmentioning

confidence: 99%

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Song

Zeng

Jiang

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…Pretreated 10 or 50 mg/kg echinacoside for 30 min on kainic acid-induced seizures rats can enhance their neuronal survival and prevent epilepsy by inhibiting glutamate excitotoxicity and autophagy, suppressing inflammation, and activating protein kinase B (Akt)/glycogen synthase kinase (GSK) 3β signaling. Therefore, it significantly increased seizure latency more than 1 h and decreased seizure severity (Lu et al, 2018a). A 4-aminopyridine (4-AP)-induced epileptiform activity with an in vitro rat hippocampal neurons' model study reported that echinacoside reduced spontaneous glutamate release, the frequency but not the amplitude of spontaneous excitatory postsynaptic currents, and the sustained repetitive firing of action potentials in hippocampal CA3 pyramidal neurons (Lu et al, 2018b).…”

Section: Cistanche Deserticolamentioning

confidence: 99%

Chinese Herbal Medicine for Treating Epilepsy

Lin

Hsieh

2021

Front. Neurosci.

View full text Add to dashboard Cite

Chinese herbal medicine has a long history of use for treating epilepsy. Because of the side effects of Western antiepileptic therapy and the quest for more accessible treatment, complementary and alternative medicines have become popular. Traditional Chinese medical diet therapy appears to be safe and effective. We searched PubMed and the Cochrane Library through November 2020 for the use of traditional Chinese medicine in clinical settings, including plants, fungi, and animals. Combinations of keywords included “epilepsy,” “seizure,” “antiepileptic,” “anticonvulsive,” “Chinese herbal medicine,” “Chinese herb,” and each of the Latin names, English names, and scientific names of herbs. We also summarized the sources and functions of these herbs in Chinese medicine. Different herbs can be combined to increase antiepileptic effects through various mechanisms, including anti-inflammation, antioxidation, GABAergic effect enhancement, modulation of NMDA channels and sodium channel, and neuroprotection. Despite reports of their anticonvulsive effects, adequate experimental evidence and randomized controlled clinical trials are required to confirm their antiepileptic effects.

show abstract

“…Previous studies have shown that the regulation of GSK3β can act as a target and modulator of antidepressant action and may be involved in the pathogenesis of depression. [10][11][12] Cyclin D1 is one of the important substrates of GSK3β. As a key protein for regulating cell cycle and cell proliferation, Cyclin D1 can bind to cyclin dependent kinase 4/6, start DNA synthesis and accelerate cell cycle progression.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis <i>via</i> GSK3β Pathway in Corticosterone Induced PC-12 Cells

Wang

Cheng

et al. 2022

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Accumulating studies suggest that hippocampal neurogenesis plays a crucial role in the pathological mechanism of depression. As a classic antidepressant, lithium chloride can play an antidepressant role by inhibiting GSK3β and promoting neurogenesis. Correspondingly, baicalin is a compound extracted from natural plants, which shows potential antidepressant effect, however, whether baicalin exerts antidepressant effects by promoting neurogenesis still needs further investigation. In the current study, we established an in vitro depression model through corticosterone induced PC-12 cells, and explored the potential mechanism of baicalin's antidepressant effect by comparing it with lithium chloride alone and the coadministration with lithium chloride. We used CCK-8 assay, EdU staining and cell cycle analysis to evaluate the state of cell survival and cell proliferation. The protein expression levels of neurodevelopmental related factors DCX, BDNF, and the GSK3β pathway-related proteins and mRNA were detected by Western blot and Real-time PCR. The results showed that baicalin could decrease the expression level of GSK3β, while upregulate the expression level of DCX, BDNF, Cyclin D1-CDK4/6, thus promoted cell proliferation and survival in CORT induced PC-12 cells. Moreover, this effect was enhanced when baicalin and lithium chloride were coadministration. Taking the above results together, we conclude that baicalin can promote the proliferation and development of PC-12 cells by regulating GSK3β pathway, so as to reverse the depressivelike pathological changes induced by corticosterone.

show abstract

Echinacoside, an Active Constituent of <i>Cistanche Herba</i>, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway

Cited by 23 publications

References 54 publications

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Chinese Herbal Medicine for Treating Epilepsy

Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis <i>via</i> GSK3β Pathway in Corticosterone Induced PC-12 Cells

Contact Info

Product

Resources

About