Echinatin maintains glutathione homeostasis in vascular smooth muscle cells to protect against matrix remodeling and arterial stiffening

Zhang, Jianrui; Xie, Sian; Wang, Jin; Liu, Jiayu; Liu, Yueqi; Zhou, Shuang; Li, Xixi; Han, Lili; Pang, Wei; Yao, Weijuan; Fu, Yi; Kong, Wei; Ye, Min; Zhou, Jing

doi:10.1016/j.matbio.2023.03.007

Cited by 13 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Isosakuranetin, found in plums and mandarin oranges, is able to relieve chronic pain in rats 72 and has been shown to be a potent inhibitor of TRPM3 channels in neurons. 73 Echinatin can protect against arterial stiffening 74 and induce apoptosis in colorectal cancer cells lines HT116 and HT29. 75 Loureirin A, found in dragon’s blood 76 was used to promote blood circulation and can relieve arthritis pain in mice.…”

Section: Discussionmentioning

confidence: 99%

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Bolt,

Oceguera,

Singh

et al. 2024

iScience

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Bolt,

Oceguera,

Singh

et al. 2024

iScience

View full text Add to dashboard Cite

“…Echinatin, a derivative of chalcone, is an active constituent found in licorice; it is obtained from the roots and rhizomes of Glycyrrhiza species (Leguminosae) and related species [2]. Recent research has substantiated the numerous clinical applications of echinatin, particularly in the realm of inhibiting tumor proliferation [3][4][5][6][7][8][9]. A study conducted by Hong et al demonstrated that echinatin induced apoptosis and autophagy by inactivating the Akt/mTOR signaling pathway, as revealed through a series of functional assays [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety

Tian,

Sun,

Zhong

et al. 2024

IJMS

View full text Add to dashboard Cite

A series of novel echinatin derivatives with 1,3,4-oxadiazole moieties were designed and synthesized. Most of the newly synthesized compounds exhibited moderate antiproliferative activity against the four cancer cell lines. Notably, Compound T4 demonstrated the most potent activity, with IC50 values ranging from 1.71 µM to 8.60 µM against the four cancer cell lines. Cell colony formation and wound healing assays demonstrated that T4 significantly inhibited cell proliferation and inhibited migration. We discovered that T4 exhibited moderate binding affinity with the c-KIT protein through reverse docking. The results were effectively validated through subsequent molecular docking and c-KIT enzyme activity assays. In addition, Western blot analysis revealed that T4 inhibits the phosphorylation of downstream proteins of c-KIT. The results provide valuable inspiration for exploring novel insights into the design of echinatin-related hybrids as well as their potential application as c-KIT inhibitors to enhance the efficacy of candidates.

show abstract

The mechanisms of ferroptosis and its role in atherosclerosis

Xu,

et al. 2024

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Echinatin maintains glutathione homeostasis in vascular smooth muscle cells to protect against matrix remodeling and arterial stiffening

Cited by 13 publications

References 45 publications

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Characterization of flavonoids with potent and subtype-selective actions on estrogen receptors alpha and beta

Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety

The mechanisms of ferroptosis and its role in atherosclerosis

Contact Info

Product

Resources

About