(+)‐Echinobetaine B: Isolation, Structure Elucidation, Synthesis and Preliminary SAR Studies on a New Nematocidal Betaine from a Southern Australian Marine Sponge, Echinodictyum sp.

Capon, Robert J.; Vuong, Dat; McNally, Michelle; Peterle, Torsten; Trotter, Nicholas S.; Lacey, Ernest; Gill, Jennifer H.

doi:10.1002/chin.200524207

Cited by 2 publications

(2 citation statements)

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“…Capon and colleagues [27,28] described two novel betaines (−)-echinobetaine A (1) and (+)-echinobetaine B (2), from the Australian sponge Echinodictyum sp. which were nematocidal (LD 99 =83 and 8.3μg/mL, respectively) to the commercial livestock parasite Haemonchus contortus .…”

Section: Marine Compounds With Anthelmintic Antibacterial Anticomentioning

confidence: 99%

Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action

Mayer

Rodrı́guez

Berlinck

et al. 2009

Biochimica et Biophysica Acta (BBA) - General Subjects

277

141

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BACKGROUND-The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented.RESULTS-Anthelminthic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. SIGNIFICANCE-Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity and will probably result in novel therapeutic agents for the treatment of multiple disease categories. CONCLUSIONS-Marine

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Section: Marine Compounds With Anthelmintic Antibacterial Anticomentioning

confidence: 99%

Marine pharmacology in 2005–6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action

Mayer

Rodrı́guez

Berlinck

et al. 2009

Biochimica et Biophysica Acta (BBA) - General Subjects

277

141

View full text Add to dashboard Cite

show abstract

“…[61], and echinobetaine B (13) from Echinodictyum sp. [62] are anthelmintic compounds from marine sponges. The preliminary SAR of the two latter nematicides revealed the importance of the N-acyl side chain in compound 12 and the importance of 2-OMe and stereopurity of the pharmacophore.…”

Section: Natural Productsmentioning

confidence: 99%

Drug Discovery and Development for Soil-Transmitted Helminthiasis: Current Anthelmentics and Compounds in the Pipeline

Tewelde¹,

Tadesse²

2023

Roundworms - A Survey From Past to Present

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Soil-transmitted helminthiasis (STH), one of 20 neglected tropical diseases, afflicts about a quarter of the world’s population. A handful of medications, albendazole, mebendazole, pyrantel pamoate, levamisole, and ivermectin, have long constituted the cornerstone of therapy for these infections in both humans and animals. The continuous and long-term reliance on these small range of compounds has led to the emergence of drug resistance in many helminthic strains in animals. The threat of resistance also seems inevitable in humans thereby hampering the World Health Organization’s efforts to control or eradicate these neglected tropical illnesses. Hence, there is an urgent need for the discovery and development of new treatment options with broad spectrum activity against various helmintic infections that act via novel mechanisms of action. Different strategies are employed in this endeavor which include the identification of promising compounds from natural and synthetic origin, drug repurposing and modification of existing drugs, and vaccine development. The prospect of a “pan-anthelmintic vaccine” also seems encouraging, despite the various obstacles facing the development of vaccines. Here we discuss drug discovery and development efforts for STH.

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(+)‐Echinobetaine B: Isolation, Structure Elucidation, Synthesis and Preliminary SAR Studies on a New Nematocidal Betaine from a Southern Australian Marine Sponge, Echinodictyum sp.

Cited by 2 publications

References 1 publication

Drug Discovery and Development for Soil-Transmitted Helminthiasis: Current Anthelmentics and Compounds in the Pipeline

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