Echinocandin-induced eosinophilia: a case report

Chua, Nathalie Grace; Zhou, Yvonne Peijun; Lingegowda, Pushpalatha Bangalore; Kwa, Andrea Lay-Hoon; Lee, Winnie

doi:10.3109/00365548.2014.938692

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…As a result, drugs were deposited in tissues, especially in the adipose tissue [3], and formed drug residues. Drug metabolism can cause not only waste but also organ damage [4]. Additionally, some bacteria evolve in the presence of the drugs and form drug resistant strains [5].…”

Section: Introductionmentioning

confidence: 99%

Studies on Target-specificity and Biological Activity of Streptococcus Serum Antibody and Sulfate Amikacin Conjugates

Dong

2019

JAMPS

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To investigate the target-specificity and biological activity of Streptococcus serum antibody and sulfate amikacin conjugates. The recent used polyethylene glycol 6000 (PEG6000) as the coupling agent to produce Coupled complexes of Streptococcus serum antibody and sulfate amikacin. Then, analyzed the antibody being in conjugates specificity which against Streptococcus, and the antibody being in conjugates immunogenicity. Besides, we also detected the acute toxicity, antimicrobial activity and bioavailability of sulfate amikacin being in conjugates. As a result, the antibody specific binding to Streptococcus, instead of Escherichia coil, Pasteurella and Staphylococcus aureus. Biological activity results showed that coupling decreased Streptococcus serum antibody immunogenicity, increased Streptococcus serum antibody response sensitivity. Simultaneously, the results indicated that coupling reduced the acute toxicity of sulfate amikacin, improved sulfate amikacin bioavailability and antimicrobial activity of sulfate amikacin. The combination effect on the Yi et al.; JAMPS, 20(2): 1-10, 2019; Article no.JAMPS.26502 2 antibacterial activity of drug and the biological activity of serum antibody is helpful for the practical application of targeted drugs. Original Research Article

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Section: Introductionmentioning

confidence: 99%

Studies on Target-specificity and Biological Activity of Streptococcus Serum Antibody and Sulfate Amikacin Conjugates

Dong

2019

JAMPS

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“…However, a connection between increased caspofungin-mediated chitin exposure and increased eosinophil activation and pathology has not been described. Two clinical reports described eosinophilia in caspofungin-treated patients with IA, although a mechanism explaining these observations was neither proposed nor examined (38, 39). When considered together, these results suggest that caspofungin has the potential to increase detrimental eosinophilia in patients with IA, although direct evidence supporting this hypothesis remains lacking.…”

Section: Introductionmentioning

confidence: 99%

Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell–Dependent Pathology in Invasive Aspergillosis

Amarsaikhan

Sands

Abdolrasouli

et al. 2017

The Journal of Immunology

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The polysaccharide-rich fungal cell wall provides pathogen-specific targets for antifungal therapy and distinct molecular patterns that stimulate protective or detrimental host immunity. The echinocandin antifungal caspofungin inhibits synthesis of cell wall β-1,3-glucan and is used for prophylactic therapy in immune suppressed individuals. However, breakthrough infections with fungal pathogen Aspergillus fumigatus are associated caspofungin prophylaxis. In this study, we report in vitro and in vivo increases in fungal surface chitin in A. fumigatus induced by caspofungin that was associated with airway eosinophil recruitment in immune competent and neutropenic mice with invasive pulmonary aspergillosis (IA). More importantly, caspofungin treatment of mice with IA resulted in a pattern of increased fungal burden and severity of disease that was reversed in eosinophil-deficient mice. In addition, the eosinophil granule proteins major basic protein and eosinophil peroxidase were more frequently detected in the bronchoalveolar lavage fluid of lung transplant patients diagnosed with IA that received caspofungin therapy when compared to azole-treated patients. Eosinophil recruitment and inhibition of fungal clearance in caspofungin-treated mice with IA required RAG1 expression and γδ T cells. These results identify an eosinophil-mediated mechanism for paradoxical caspofungin activity and support the future investigation of the potential of eosinophil or fungal chitin-targeted inhibition in the treatment of IA.

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Anidulafungin/caspofungin

2014

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Echinocandin-induced eosinophilia: a case report

Cited by 4 publications

References 10 publications

Studies on Target-specificity and Biological Activity of Streptococcus Serum Antibody and Sulfate Amikacin Conjugates

Studies on Target-specificity and Biological Activity of Streptococcus Serum Antibody and Sulfate Amikacin Conjugates

Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell–Dependent Pathology in Invasive Aspergillosis

Anidulafungin/caspofungin

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