Echocardiographic abnormalities in cirrhosis &amp; their correlation with severity of cirrhosis using Child-Pugh score among patients in a tertiary care hospital

Balde, Jagruti; Rao, Karthik; Ballala, Kirthinath; Samanth, Jyothi; Shetty, Ranjan; Patil, Navin; Aujayeb, Avinash; Varghese, George

doi:10.4103/ijmr.ijmr_1486_15

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…However, TAPSE and parameters of DD correlated with severity of liver disease as seen by natural PELD/MELD score, prothrombin time, INR and decompensated portal hypertension. Evidence of this is in contrast to a study of patients with cirrhosis where no signi cant association was found between echocardiographic changes and Child-Pugh score (25).…”

Section: Discussioncontrasting

confidence: 99%

Evaluation Of Cardiac Function in Children Undergoing Liver Transplantation

Bansal,

Mahgerefteh,

Lamour

et al. 2024

Preprint

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Introduction: Cirrhotic cardiomyopathy is a complication of cirrhosis resulting in cardiac dysfunction. It remains poorly characterized in children. The aim of this study was to assess relationship of pre liver transplant (LT) conventional and novel parameters of biventricular function with post-LT clinical course. Methods: This is a retrospective study of pre-LT echocardiograms performed on patients <18 years of age with cirrhosis at a single centre, who received a LT. Demographic, clinical and echocardiographic data was collected. Speckle tracking echocardiography (STE) analysis was performed by a single observer using TomTec system. Descriptive data was expressed as mean (SD) and number (%). The relationship between clinical data and echocardiographic variables were assessed using Spearman correlation coefficient. Significance was set at < 0.05. Results: Thirty-five patients (median age 6.5; IQR 14.2 years) underwent LT between 2010-2020. Pre LT diagnosis was biliary atresia in 14 (40%) patients and 7 (20%) patients were listed as status 1A/1B. Their median natural pediatric/model end-stage liver disease score was 13 (IQR 9). Their pre-LT echocardiogram showed normal left ventricular systolic (LV) function by ejection fraction and strain parameters. Right ventricular (RV) function was abnormal in 74% of patients as measured by RV GLS (23 ± 3%). There was correlation between echocardiographic parameters with pre transplant clinical disease and post-operative LT course (length of stay and duration of mechanical ventilation). Conclusions: Children undergoing liver transplant have RV dysfunction as evidenced by abnormal RV GLS on STE. There is echocardiographic parameter correlation between clinical liver disease and post-LT clinical course.

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Section: Discussioncontrasting

confidence: 99%

Evaluation Of Cardiac Function in Children Undergoing Liver Transplantation

Bansal,

Mahgerefteh,

Lamour

et al. 2024

Preprint

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“…An Indian study reported a very high prevalence of POPH (35.71%). [ 26 ] In our study, the worsening Child scores did not significantly alter the prevalence of POPH, which was in line with the findings of similar studies. [ 26 27 28 29 30 ] High mPAP and PVR during right heart catheterization were diagnostic of POPH.…”

Section: Discussionsupporting

confidence: 93%

“…[ 26 ] In our study, the worsening Child scores did not significantly alter the prevalence of POPH, which was in line with the findings of similar studies. [ 26 27 28 29 30 ] High mPAP and PVR during right heart catheterization were diagnostic of POPH. [ 22 ] 2D echocardiography finding of high right ventricular systolic pressure (>25 mmHg) is also a fairly good indicator of POPH.…”

Section: Discussionsupporting

confidence: 93%

Pulmonary Dysfunction in Patients with Cirrhosis of the Liver: A Study of Pulmonary Function Tests and Arterial Blood Gases

Vaishnav,

Barla,

Ruchitha

et al. 2024

International Journal of Applied &Amp; Basic Medical Research

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Background and Aim: Respiratory complications in liver cirrhosis can occur due to various mechanisms, such as ascites causing restricted lung expansion and opening of intrapulmonary vascular shunts due to high portal pressures. We aimed to study the effects of the liver dysfunction on the lungs by evaluating arterial blood gas (ABG) and pulmonary function test (PFT) of all study subjects. Subjects and Methods: A cross-sectional study was done between August 2020 and September 2022. Diagnosed cases of the liver cirrhosis were enrolled in the study after informed consent and were subjected to the following investigations: chest X-ray, oximetry, spirometry, diffusing capacity of the lung for carbon monoxide (DLCO), two-dimensional echocardiography, and ABG analysis (ABGA). The cases were divided into three groups based on their Child–Pugh staging, and statistical analysis was done on the collected data. Results: A total of 64 (53 males and 11 females) patients with an average age of 49.82 ± 9.89 years were studied. Alcoholism was the most common cause of cirrhosis in males. Breathlessness (65.6%) and pleural effusion (26.6%) were the most common respiratory symptoms and signs, respectively. Seventeen patients had hepatic hydrothorax, eight patients had hepatopulmonary syndrome (HPS), and six patients had portopulmonary hypertension. Low pH (17.2%) and oxygen partial pressure (PaO2) (20.3%) were the most common ABGA findings. The pH, PaO2, forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), and DLCO were significantly low in Child Pugh Stage C (P < 0.05). The pH, pO2, HCO3, FEV1, FVC, FEV1/FVC, and DLCO were significantly lower in patients with HPS (P < 0.05). Conclusion: Metabolic acidosis and low FEV1/FVC and DLCO were the common findings in study subjects. Pulmonary dysfunction was common in advanced liver cirrhosis. Patients with HPS had worse ABG and PFT parameters than those without HPS.

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“…The circulatory dysfunction described during cirrhosis responsible for hypovolemia could explain these electrical abnormalities [5] [18]. However, more in-depth studies using holter-ECG combined with plasma calcium measurement will enable a better assessment of the QT interval in cirrhosis patients, as recommended by patients, found no association between echographic cardiac abnormalities and Child Pugh score, in contrast to our findings [14]. Some authors have shown a link between advanced fibrosis and the risk of heart failure and death [24].…”

Section: Discussioncontrasting

confidence: 85%

Cardiovascular Disorders in Cirrhosis at the Brazzaville Teaching Hospital in 2022

Ngami,

Mikolele Ahoui Apendi,

Itoko Okombi

et al. 2023

OJGas

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Cirrhosis is a liver disease that can lead to cardiovascular lesions that are often asymptomatic but potentially fatal. Objective: The aim of this study was to evaluate electrical and echographic cardiovascular abnormalities during cirrhosis at the Brazzaville University Hospital. Patients and Methods: We conducted a cross-sectional analytical study over a 2-year period at the Brazzaville Universitary Hospital. Cirrhotic patients at least 18 years of age who had undergone electrocardiogram and echocardiography were included. Patients with cardiac cirrhosis, hepatocellular carcinoma or spontaneous bacterial peritonitis were excluded. The outcome variables were cardiac electrical and echographic abnormalities. Data were analyzed using Epi info 7.2 software. Pearson's chi-square, Fisher's exact and Student's exact tests were used to compare proportions and means at a significance level of 0.05. Results: A total of 76 cirrhotic patients were recruited out of 186 patients, i.e. 40.

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Echocardiographic abnormalities in cirrhosis & their correlation with severity of cirrhosis using Child-Pugh score among patients in a tertiary care hospital

Cited by 5 publications

References 13 publications

Evaluation Of Cardiac Function in Children Undergoing Liver Transplantation

Evaluation Of Cardiac Function in Children Undergoing Liver Transplantation

Pulmonary Dysfunction in Patients with Cirrhosis of the Liver: A Study of Pulmonary Function Tests and Arterial Blood Gases

Cardiovascular Disorders in Cirrhosis at the Brazzaville Teaching Hospital in 2022

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