Echocardiographic and electrocardiographic characteristics of patients with hypertrophic cardiomyopathy with and without mitral anular calcium

Nair, Chandra K.; Kudesia, Vijay S.; Hansen, Dale; Thomson, W. H.; Pagano, Tom; Ryschon, Kay; Sketch, Michael H.

doi:10.1016/0002-9149(87)90938-6

Cited by 19 publications

(5 citation statements)

References 8 publications

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“…Systemic hyper tension and female sex were risk factors for mitral anular calcification in 46 of 80 nonrenal patients in a roentgenographic survey by Fulkerson et al [16], Diffuse conduction disease in 44 patients required pacemakers in 21 patients. Serum phosphorus (3.75 vs. 3.39 mg/dl) and calcium phos phorus products (34.7 vs. 31.2) were increased over agematched controls in 107 patients (55 men, 52 women) <60 years of age with mitral anulus calcification studied by Nair et al [12]. This was associated with systemic hypertension, échocardiographie left atrial and ventricular enlargement, but comparable serum levels of cholesterol, triglycerides, calcium and alkaline phosphatase.…”

Section: Risk Factors O F MC In the General Populationmentioning

confidence: 91%

“…The presented findings suggest that: (1) Thorough con trol of arterial blood pressure during the predialysis period and of calcium-phosphorus products at the time of ESRD is important to prevent the development of MC [8, 9,12]; (2) Special attention from the cardiologist's standpoint should be given to patients with MC and reduced systolic LV function and to patients with severe MC or severe mitral regurgitation, which may predict an unfavorable outcome. Adequate treatment of MC-associated problems such as coronary artery [3,4,15] and aortic valve calcification [16] LV and left atrial enlargement [9,II], atrial fibrillation [8,16], bacterial endocarditis with arterial embolism [16] and severe conduction defects [12,16] must be achieved to improve the high mortality of these patients.…”

Section: Clinical Relevance O F Findingsmentioning

confidence: 99%

“…Adequate treatment of MC-associated problems such as coronary artery [3,4,15] and aortic valve calcification [16] LV and left atrial enlargement [9,II], atrial fibrillation [8,16], bacterial endocarditis with arterial embolism [16] and severe conduction defects [12,16] must be achieved to improve the high mortality of these patients.…”

Section: Clinical Relevance O F Findingsmentioning

confidence: 99%

“…While severe valve disease in patients with ESRD has a comparable prognosis and operative treatment as in nonrenal patients, no information is available on the prognostic significance of valvular sclerosis that does not require surgi cal intervention : valvular sclerosis may be a useful noninvasive marker of cardiac disease associated with reduced Accepted : May 5.1992 survival such as fibrosis and calcification of the myocar dium, conduction system, endo-and pericardium [8][9][10][11][12], Since sclerosis or calcification of the mitral valve or anulus (MC) is a characteristic finding in these patients, the association of this marker with survival or nonsurvival was investigated. Therefore, to assess the predictive value of nonsignificant valve disease for survival, the clinical course of 53 patients treated with continuous ambulatory perito neal dialysis (CAPD) was studied over 35 months using clinical, chemical, échocardiographie and Doppler écho cardiographie parameters.…”

Section: Introductionmentioning

confidence: 99%

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Predictive Value of Mitral and Aortic Valve Sclerosis for Survival in End-Stage Renal Disease on Continuous Ambulatory Peritoneal Dialysis

Hüting

1993

Nephron

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To determine whether mitral valve or anular sclerosis or calcification (MC) is associated with reduced survival in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD), 53 CAPD patients were followed with echocardiography and Doppler echocardiography over 35 months. Both nonsurvivors and survivors with MC had higher systolic blood pressure before CAPD and calcium-phosphorus products during CAPD treatment than patients without MC (p < 0.05). Serum calcium and phosphorus concentrations, alkaline phosphatase and parathyroid hormone activities were higher in nonsurvivors and survivors with than without MC (p > 0.05). Left ventricular end-diastolic and end-systolic volumes were greater (p < 0.01), ejection fractions were smaller (p < 0.05) in nonsurvivors with than without MC, but not in survivors with versus without MC. Severe MC and grade III mitral valve regurgitation were more frequent in nonsurvivors than in survivors (p < 0.03). No valvular stenoses were found. It is concluded that the development of MC is favored by long-standing predialysis arterial hypertension and by high calcium-phosphorus products during CAPD. Nonsurvivors with MC are characterized by reduced systolic left ventricular function or severe valvular lesions. A close cardionephrologic cooperation is necessary to improve the survival of CAPD patients with these risk factors.

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Section: Risk Factors O F MC In the General Populationmentioning

confidence: 91%

Section: Clinical Relevance O F Findingsmentioning

confidence: 99%

Section: Clinical Relevance O F Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Predictive Value of Mitral and Aortic Valve Sclerosis for Survival in End-Stage Renal Disease on Continuous Ambulatory Peritoneal Dialysis

Hüting

1993

Nephron

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“…28 Physiological mineralization occurs in hard tissues, whereas pathological calcification occurs at several sites in the cardiovascular system, including the intima and media of vessels and cardiac valves. 29 It was reported that mitral annular calcification was present in 12 of 42 (29%) HCM patients, 30 accounting for a not small proportion. We assumed that there was a certain relationship between ALP and mitral annular calcification.…”

Section: Discussionmentioning

confidence: 97%

Prognostic significance of serum alkaline phosphatase for all-cause mortality in patients with hypertrophic cardiomyopathy: A cohort of the hospitalized population

et al. 2022

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Higher levels of serum alkaline phosphatase (ALP) as a novel risk factor was recently found associated with mortality in different population, whereas, the relationship remains unknown in hypertrophic cardiomyopathy (HCM) population. In this study, we hypothesized that increased ALP could predict all-cause mortality in the adult HCM population. In this cohort study, retrospective data from 538 HCM patients consecutively recruited in West China Hospital were collected. Patients were divided into two groups by baseline ALP with 80 IU/L as the cutoff. All-cause mortality was set as the endpoint. Subgroup analysis was conducted in patients with normal liver function. In total, 461 adult HCM patients were included. After a median follow-up of 4.7 years, 91 patients died. Alkaline phosphatase was an independent predictor of all-cause mortality since patients in the higher ALP group had an increased risk (adjusted HR 2.0, 95% CI: 1.3–3.3, P < 0.01) compared with those in the lower ALP group. In subgroup analysis, the relationship was consistent with the overall (adjusted HR: 3.0, 95% CI: 1.7–5.3, P < 0.01 for the higher ALP group). In the Chinese cohort study of HCM patients, serum ALP is independently associated with all-cause mortality. Patients with a measured value above 80 IU/L had an increased risk of all-cause mortality and this cutoff might help with risk stratification in HCM population.

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Mitral annular calcification and coarctation of aorta

Nair

Ahmed

Sketch

1988

Clinical Cardiology

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Summary:Although coarctation of the aorta is associated with various cardiac abnormalities, its association with mitral annular calcification (MAC) is not reported. We therefore report a 37-year-old patient with postductal Coarctation of the aorta and MAC, Considered to be a degenerative process, MAC is usually seen in elderly patients. It is uncommon in patients less than 50 years old and rare before the age of 40 years. Previous studies have reported increased frequency of cardiac conduction disturbances in patients with MAC compared to age-and sexmatched controls. This is in agreement with complete right bundle-bmch block noted on the e l m 'ogram of our patient. Clinicopathologic correlative studies and longterm follow-up may determine how such conduction distrubances develop and progress.

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Echocardiographic and electrocardiographic characteristics of patients with hypertrophic cardiomyopathy with and without mitral anular calcium

Cited by 19 publications

References 8 publications

Predictive Value of Mitral and Aortic Valve Sclerosis for Survival in End-Stage Renal Disease on Continuous Ambulatory Peritoneal Dialysis

Predictive Value of Mitral and Aortic Valve Sclerosis for Survival in End-Stage Renal Disease on Continuous Ambulatory Peritoneal Dialysis

Prognostic significance of serum alkaline phosphatase for all-cause mortality in patients with hypertrophic cardiomyopathy: A cohort of the hospitalized population

Mitral annular calcification and coarctation of aorta

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