Echocardiography has been around for more than half a century [1]. Recent decades have seen significant technological advances, with increasing clinical applications of this non-invasive imaging tool, beyond the basic assessment of left ventricular function, with further evolution evident on the horizon. There has also been a burgeoning increase in use: According to the 2017 Australian Medicare Medical Benefits Schedule (MBS) Taskforce, about 900,000 echocardiographic procedures (excluding stress echo) are reimbursed annually, at a cost of over $180 million each year [2]. In addition, the use of echo is growing at a rate of about 8.8% each year [3]. Stress echocardiography accounts for over $56 million in billing annually in Australia and has grown each year at a rate of 12% for the past 5 years [4]. In recognition of this expanding use, this fully commissioned Special Issue of Heart, Lung and Circulation presents an overview of contemporary practice in echocardiography.