“…These monitoring systems display the late findings of VAE, detecting the complications of VAE and severe physiologic deterioration caused by V A /Q mismatch, right and/or left heart failure, or paradoxical arterial air embolism (13, 34, 58). Therefore, these methods are not suitable for the early detection of VAE, especially in patients under general anesthesia without N 2 O, and negative findings do not guarantee the absence of VAE.…”