Echocardiographic Doppler Assessment of the Biophysical Properties of the Aorta in Pediatric Patients With the Marfan Syndrome

Bradley, Timothy J.; Potts, James E.; Potts, Mary T.; DeSouza, Astrid; Sandor, George G.S.

doi:10.1016/j.amjcard.2005.06.080

Cited by 39 publications

(50 citation statements)

References 20 publications

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“…Another study actually measured pulse wave velocity analysis was performed by Bradley, Potts et al (2005) that showed that Marfan patients have increased pulse wave velocity compared with normal subjects (48.1 ± 7.0 vs. 35.7 ± 6.1 m/s, p < 0.0001) (Bradley, Potts et al 2005). …”

Section: Aortic Stiffnessmentioning

confidence: 99%

“…On the same image plane, PW Doppler Mode sample volume was placed as distal as possible in the descending aorta and the time (T2) from the onset of the QRS complex to the onset of the ascending aortic Doppler waveform was measured (Bradley, Potts et al 2005). T1 and T2 were averaged over 10 cardiac cycles.…”

Section: Pulse Wave Velocity Analysismentioning

confidence: 99%

“…2.5) (Hirata, Triposkiadis et al 1991). PW Doppler Mode sample volume was placed in the ascending aorta and the time (T1) from the onset of the QRS complex to the onset of the ascending aortic Doppler waveform was measured (Bradley, Potts et al 2005). …”

Section: Pulse Wave Velocity Analysismentioning

confidence: 99%

“…T1 and T2 were averaged over 10 cardiac cycles. The aortic arch distance was measured between the 2 sample volume positions along the central axis of aortic arch on the B-mode image, and the transit time was calculated by T2 -T1 (ms) (Bradley, Potts et al 2005). .…”

Section: Pulse Wave Velocity Analysismentioning

confidence: 99%

“…Aortic root dilation is the earliest and most common manifestations of cardiovascular Marfan disease, which is defined as the major criteria by the revised Ghent criteria (Table 1.1) (De Paepe, Devereux et al 1996). In addition to evaluating the structural and functional properties of the heart and aorta, pulse wave (PW) velocity measurements allow one to estimate the level of aorta stiffness (Bradley, Potts et al 2005), and strain analysis can be used for detecting deformation of the heart (Angtuaco, Vyas et al 2012).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

In Vivo Measurements of Biophysical Properties of a Heart and Aorta in a Mouse Model of Marfan Syndrome

Lee

Esfandiarei

Sheng

et al. 2014

Canadian Journal of Cardiology

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In Marfan Syndrome (MFS) patients cardiovascular complications are the most life-threatening manifestations and death is often sudden due to aortic dissection and rupture. Echocardiography is critical in the diagnosis and follow-up of MFS patients to detect and evaluate their cardiovascular phenotype. High frequency echocardiography was used to investigate the structural and functional properties on 6-and 12-mo WT and MFS [Fbn1 (C1039G/+)] mice (n = 8). The data show that Pulse Wave Velocity (PWV) was significantly increased in 6-mo MFS vs. WT (366.6 ± 19.9 vs. 205.2 ± 18.1 cm/s; p < 0.001) and 12-mo MFS vs. WT (459.5 ± 42.3 vs. 205.3 ± 30.3 m/s; p = 0.001) and the PWV increased directly in proportion to age in MFS mice but not in WT mice. LV mass (3.06 ± 0.16 vs. 2.46 ± 0.09 μm/g; p = 0.007) was significantly increased in 6-mo MFS mice compared with WT. We also found a significantly enlarged aortic root, decreased E/A ratio, prolonged isovolumic relaxation time and increased myocardial performance index in MFS mice compared with WT for both age groups. This study shows significant aortic dilation and central aortic stiffness in the MFS mice which are associated with LV hypertrophy, systolic and diastolic dysfunction. Moreover, the symptoms progressed with increasing age from six months to twelve months.

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Section: Aortic Stiffnessmentioning

confidence: 99%

Section: Pulse Wave Velocity Analysismentioning

confidence: 99%