Echocardiographic evaluation in patients with autosomal dominant polycystic kidney disease and end-stage renal disease

Martínez-Vea, Alberto; Bardajı́, Alfredo; Gutiérrez, Cristina; García, Caridad Jacas; Peralta, Carmen; Aguilera, Josep; Sanchez, Pere; Vidiella, Joan; Angelet, P; Compte, Teresa González; Richart, C; Oliver, J.

doi:10.1016/s0272-6386(99)70354-9

Cited by 8 publications

(8 citation statements)

References 42 publications

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“…The mean age of 116 ADPKD patients in this echocardiographic study was 41 years. Several other studies also showed a significant association between LVH and renal function in ADPKD patients [10]. Our ADPKD patients had serum creatinine concentrations of 0.84 ± 0.18 mg/dL and did not differ in this respect from the control group.…”

Section: Resultssupporting

confidence: 68%

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Autosomal Dominant Polycystic Kidney Disease and Hypertension are Associated with Left Ventricular Mass in a Gender-Dependent Manner

Pietrzak-Nowacka

Safranow

Czechowska

et al. 2012

Kidney Blood Press Res

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Background: The aim of this study was to compare echocardiographic parameters in patients with autosomal dominant polycystic kidney disease (ADPKD) and in controls with normal kidney function taking into account gender and the presence of hypertension. Methods: 47 patients with ADPKD (age 36.3 ± 11.0 years) and 49 healthy controls (36.8 ± 9.2 years) were enrolled. M-mode echocardiography was performed in all subjects. Left ventricular hypertrophy (LVH) was diagnosed when the left ventricular mass index (LVMI) was greater than or equal to 125 g/m² in males and 110 g/m² in females. Results: The prevalence of LVH was greater in ADPKD patients than in controls (13% vs 2%; p=0.05). Among females, ADPKD patients demonstrated greater LVMI (87.9 ± 18.5 vs 68.8 ± 15 g/m², p=0.00009) than controls. There was a positive correlation between LVMI and blood pressure in ADPKD females (Rs=0.54, p=0.027 for systole blood pressure-SBP and Rs=0.50, p=0.0053 for diastole blood pressure-DBP) but not in males. Conclusion: Left ventricular mass is increased in ADPKD females with normal renal function. A positive correlation between SBP and DBP and LVMI was found in ADPKD females but not in ADPKD males.

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Section: Resultssupporting

confidence: 68%

“…Factors contributing to LVH in ADPKD include older age, elevated serum creatinine and uric acid levels, increased mean arterial blood pressure, and longer history of hypertension [9,10]. Bardaji et al showed that hypertensive ADPKD subjects demonstrate an increase in left ventricular mass (LVM) correlating with loss of renal function [11].…”

Section: Introductionmentioning

confidence: 99%

Autosomal Dominant Polycystic Kidney Disease and Hypertension are Associated with Left Ventricular Mass in a Gender-Dependent Manner

Pietrzak-Nowacka

Safranow

Czechowska

et al. 2012

Kidney Blood Press Res

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“…4,40 On the other hand, previous studies comparing patients with ADPKD to nondiabetic kidney failure patients on dialysis or after transplantation showed no significant difference in the LVH prevalence. 15,16 In our study, we found that at time of transplantation, patients with ADPKD had less LVH and lower LV mass index as compared with patients without ADPKD. Furthermore, when comparing cardiovascular findings before and after transplantation, we observed an increase in LVH rates post-KT in all groups except DN, who already had a very high prevalence of LVH pretransplantation.…”

Section: Discussionsupporting

confidence: 49%

“…14 Two previous studies assessed the prevalence of cardiovascular abnormalities in the ADPKD population and compared it to other patients with kidney failure at the time of transplantation, but the number of patients with ADPKD was limited. 15,16 In addition, the control groups of these studies did not include patients with diabetes, who are the most predisposed to cardiovascular disease among patients with patients with CKD. 17 Furthermore, results from studies evaluating posttransplantation cardiovascular outcomes in patients with ADPKD compared with nondiabetic kidney failure patients have been controversial.…”

mentioning

confidence: 99%

Cardiovascular Outcomes in Kidney Transplant Recipients With ADPKD

Chedid

Kaidbay²,

Wigerinck³

et al. 2022

Kidney International Reports

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“…ADPKD patients also have an increased risk of tricuspid valve prolapse (6%). Mitral and aortic incompetence also has been detected more frequent in ADPKD patients (31 and 8 percent respectively) (Hossack et al 1988;Timio et al 1992;Martinez-Vea 1999).…”

Section: Masoumi Et Almentioning

confidence: 98%

Developments in the management of autosomal dominant polycystic kidney disease

Schrier¹

2008

TCRM

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Abstract:Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent life-threatening, hereditary disease. ADPKD is more common than sickle cell anemia, cystic fi brosis, muscular dystrophy, hemophilia, Down's syndrome, and Huntington's disease combined. ADPKD is a multisystemic disorder characterized by the progressive development of renal cysts and marked renal enlargement. Structural and functional renal deterioration occurs in ADPKD patients and is the fourth leading cause of end-stage renal disease (ESRD) in adults. Aside from the renal manifestations, extrarenal structural abnormalities, such as liver cysts, cardiovascular abnormalities, and intracranial aneurysms may lead to morbidity and mortality. Recent studies have identifi ed prognostic factors for progressive renal impairment including gender, race, age, proteinuria, hematuria, hypertension and increased left ventricular mass index (LVMI). Early diagnosis and better understanding of the pathophysiology of the disease provides the opportunity to aggressivly treat hypertension with renin-angiotensin-aldosterone system inhibitors and thereby potentially reduce LVMI, prevent cardiovascular morbidity and mortality and slow progression of the renal disease.

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Echocardiographic evaluation in patients with autosomal dominant polycystic kidney disease and end-stage renal disease

Cited by 8 publications

References 42 publications

Autosomal Dominant Polycystic Kidney Disease and Hypertension are Associated with Left Ventricular Mass in a Gender-Dependent Manner

Autosomal Dominant Polycystic Kidney Disease and Hypertension are Associated with Left Ventricular Mass in a Gender-Dependent Manner

Cardiovascular Outcomes in Kidney Transplant Recipients With ADPKD

Developments in the management of autosomal dominant polycystic kidney disease

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