Echocardiographic Strain Analysis for the Early Detection of Myocardial Structural Abnormality and Initiation of Drug Therapy in a Mouse Model of Dilated Cardiomyopathy

Minjuan, Zheng; Pan, Feng; Liu, Ying; Li, Zhenzhou; Zhou, Xiaodong; Meng, Xin; Liu, Liwen; Ge, Shuping

doi:10.1016/j.ultrasmedbio.2017.07.020

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…The purpose of this study was to provide a comparison between conventional echocardiographic measurements and STE analysis to understand whether age-related changes in LV systolic and diastolic function could be detected earlier and more accurately with STE, as previously described in other mouse models and human patients (12,13,20,25,31,32). Furthermore, we assessed whether LV regional contractility and synchronicity were impaired in our mouse model of physiological aging, similar to what has been reported in humans (17).…”

Section: Discussionmentioning

confidence: 99%

“…Our findings demonstrated the superiority and higher sensitivity of STE in detecting subtle age-dependent changes in LV global and regional systolic function compared with conventional ECHO, as shown in other murine models of cardiac disease (myocardial infarction, pressure overload, chemotherapy-induced cardiotoxicity, and diabetic cardiomyopathy) (12,13,25,26,37,38). Koch colleagues (20) showed that circumferential strain and radial displacement were unchanged during aging in mice. These results are not in line with data from healthy older individuals (impaired longitudinal, radial, and circumferential strain when compared with young and middle-aged adults) and were limited by the retrospective nature of the study, a parasternal short-axis approach, and the evaluation of mice that had not aged enough (16-month-old) (16,21).…”

Section: Discussionmentioning

confidence: 99%

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Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

Lucia

Wallner

Eaton

et al. 2018

The Journals of Gerontology: Series A

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Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease and the senescent heart is characterized by structural and functional changes including diastolic and systolic dysfunction as well as left ventricular (LV) dyssynchrony. Speckle-tracking based strain echocardiography (STE) has been shown as a non-invasive, reproducible and highly sensitive methodology to evaluate LV function in both animal models and humans. Herein, we describe the efficiency of this technique as a comprehensive and sensitive method for the detection of age-related cardiac dysfunction in mice. Compared to conventional echocardiographic measurements, radial and longitudinal strain, and reverse longitudinal strain were able to detect subtle changes in systolic and diastolic cardiac function in mice at an earlier time-point during aging. Additionally, the data show a gradual and consistent decrease with age in regional contractility throughout the entire LV, in both radial and longitudinal axes. Furthermore, we observed that LV segmental dyssynchrony in longitudinal axis reliably differentiated between aged and young mice. Therefore, we propose the use of echocardiographic strain as a highly sensitive and accurate technology enabling the evaluating the effect of new treatments to fight age-induced cardiac disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

Lucia

Wallner

Eaton

et al. 2018

The Journals of Gerontology: Series A

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“…Since GLS in particular has been shown to provide a good prognosis for many heart failure-related outcomes independent of EF [ 34 ], we decided to focus on this parameter for this study. Previous studies in mouse models of DCM [ 35 ], sepsis [ 36 ], obesity [ 37 ] have shown significant changes in GLS prior to changes in EF. However, we did not find a significant main effect of time for GLS in either of the groups.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal CMR assessment of cardiac global longitudinal strain and hemodynamic forces in a mouse model of heart failure

Daal

Strijkers

Hautemann

et al. 2022

Int J Cardiovasc Imaging

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To longitudinally assess left ventricle (LV) global longitudinal strain (GLS) and hemodynamic forces during the early stages of cardiac dysfunction in a mouse model of heart failure with preserved ejection fraction (HFpEF). Cardiac MRI measurements were performed in control mice (n = 6), and db/db mice (n = 7), whereby animals were scanned four times between the age of 11–15 weeks. After the first scan, the db/db animals received a doxycycline intervention to accelerate progression of HFpEF. Systolic function was evaluated based on a series of prospectively ECG-triggered short-axis CINE images acquired from base to apex. Cardiac GLS and hemodynamic forces values were evaluated based on high frame rate retrospectively gated 2-, 3-, and 4-chamber long-axis CINE images. Ejection fraction (EF) was not different between control and db/db animals, despite that cardiac output, as well as end systolic and end diastolic volume were significantly higher in control animals. Whereas GLS parameters were not significantly different between groups, hemodynamic force root mean square (RMS) values, as well as average hemodynamic forces and the ratio between hemodynamic forces in the inferolateral-anteroseptal and apical–basal direction were lower in db/db mice compared to controls. More importantly, hemodynamic forces parameters showed a significant interaction effect between time and group. Our results indicated that hemodynamic forces parameters were the only functional outcome measure that showed distinct temporal differences between groups. As such, changes in hemodynamic forces reflect early alterations in cardiac function which can be of added value in (pre)clinical research on HFpEF.

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“…The endocardial and epicardial boundary were manually circled and the related parameters of endocardium and epicardium were measured both in longitudinal and circumferential axial plane. The measurement indexes included: left ventricular area change fraction (FAC), left ventricular global longitudinal strain peak (GLS), global radial strain peak (GRS) and global circumferential strain peak (GCS) (23).…”

Section: Echocardiography and Measurement Of Invasive LV Hemodynamicmentioning

confidence: 99%

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

Yan

Yang

et al. 2021

Front. Cardiovasc. Med.

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Objectives: Large ventricular aneurysm secondary to myocardial infarction (MI) results in severe heart failure (HF) and limits the effectiveness of regeneration therapy, which can be improved by surgical ventricular reconstruction (SVR). However, the conventional SVR procedures do not yield optimal long-term outcome in post-MI rodents. We hypothesized that a modified SVR procedure without aggressive purse string suture would persistently alleviate HF and improve cardiac regeneration in post-MI mice.Methods: Adult male C57 mice were subjected to MI or sham surgery. Four weeks later, mice with MI underwent SVR or 2nd open-chest operation alone. SVR was performed by plicating the aneurysm with a single diagonal linear suture from the upper left ventricle (LV) to the right side of the apex. Cardiac remodeling, heart function and myocardial regeneration were evaluated.Results: Three weeks after SVR, the scar area, LV volume, and heart weight/body weight ratio were significantly smaller, while LV ejection fraction, the maximum rising and descending rates of LV pressure, LV contractility and global myocardial strain were significantly higher in SVR group than in SVR-control group. The inhibitory effects of SVR on LV remodeling and HF persisted for at least eight-week. SVR group exhibited improved cardiac regeneration, as reflected by more Ki67-, Aurora B- and PH3-positive cardiomyocytes and a higher vessel density around the plication area of the infarcted LV.Conclusions: SVR with a single linear suture results in a significant and sustained reduction in LV volume and improvement in both LV systolic and diastolic function as well as cardiac regeneration.

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Echocardiographic Strain Analysis for the Early Detection of Myocardial Structural Abnormality and Initiation of Drug Therapy in a Mouse Model of Dilated Cardiomyopathy

Cited by 6 publications

References 24 publications

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

Longitudinal CMR assessment of cardiac global longitudinal strain and hemodynamic forces in a mouse model of heart failure

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

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