this retrospective cohort study investigated the association between in-hospital survival and twodimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHCA). The 2D-echo and non-2D-echo groups comprised eligible patients who underwent transthoracic 2D echocardiography performed by the cardiology team within 24 hours after ROSC and those who did not, respectively. After propensity score (PS) matching, 142 and 284 patients in the 2D-echo and non-2D-echo groups, respectively, were included. A logistic regression analysis showed that the likelihood of in-hospital survival was 2.35-fold higher in the 2D-echo group than in the non-2D-echo group (P < 0.001). Regarding IHCA aetiology, in-hospital survival after cardiac arrest of a cardiac cause was 2.51-fold more likely in the 2D-echo group than in the non-2D-echo group (P < 0.001), with no significant inter-group difference in survival after cardiac arrest of a non-cardiac cause (P = 0.120). In this study, 2D echocardiography performed within 24 hours after ROSC was associated with better in-hospital survival outcomes for patients who underwent ICPR for IHCA with a cardiac aetiology. Thus, 2D echocardiography may be performed within 24 hours after ROSC in patients experiencing IHCA to enable better treatment.In-hospital cardiac arrest (IHCA) is an important determinant of in-hospital mortality 1 . According to recent reports, 290,000 cases of IHCA occur annually in the U.S 2 . Among these, approximately 2.73 patients per 1000 patients with IHCA who undergo in-hospital cardiopulmonary resuscitation (ICPR) are elderly inpatients 3,4 . Despite steady increases in the post-IHCA survival rate due to improvements in the quality of patient care 5 , survival remains a significant challenge in this population 2 .Two-dimensional (2D) echocardiography is a rapid, safe, and non-invasive modality used to examine the motion of the heart. In addition to its usefulness for treating and evaluating patients in intensive care unit (ICU) settings 6 , 2D echocardiography has been reported to play a major role in vasopressor dose adjustments or fluid management during the treatment of patients with shock 7,8 . In patients with IHCA, 2D echocardiography has been shown to facilitate the rapid detection or exclusion of various aetiologies during the peri-resuscitative period and to help physicians identify targets for possible correction 9 . Furthermore, 2D echocardiography is useful for the diagnosis and treatment of post-arrest myocardial dysfunction (PAMD), a common condition affecting patients who achieve return of spontaneous circulation (ROSC) after IHCA 10-12 . Accordingly, 2D echocardiography may be useful for improving post-ROSC survival for patients who undergo ICPR for IHCA. However, available information related to this topic remains insufficient.Therefore, this study aimed to investigate the association between in-hospit...