<p>This manuscript looks at basic limitations of alcohol septal ablation in obstructive hypertrophic cardiomyopathy. They include high-grade atrioventricular blockages, residual obstructions of the left ventricular outflow tract and the so-called proarrhythmic effects of alcohol septal ablation procedure. All these weaknesses are reviewed in the context of incidence, etiology, and prevention.</p><p>Received 25 February 2017. Accepted 10 April 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> The authors declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Conception and study design: M.G. Kashtanov.<br />Data collection and analysis: M.G. Kashtanov.<br />Drafting the article: M.G. Kashtanov, E.M. Idov.<br />Final approval of the version to be published: M.G. Kashtanov, S.D. Chernyshev, L.V. Kardapoltsev, S.V. Berdnikov, E.M. Idov.</p><p>Full text of the article is in the online version of this paper at <a href="http://dx.doi.org/10.21688/1681-3472-2017-3-12-22">http://dx.doi.org/10.21688/1681-3472-2017-3-12-22</a></p>