Pancreatic size and pancreatic echo amplitude were examined to determine their value for distinguishing chronic pancreatitis from normal. Using patients with cystic fibrosis as a model for chronk• pancreatitis, a prospective study was performed comparing 16 patients with this disease and 16 normals. Absolute measurements of the pancreatic body and the ratio of pancreatic size to vertebral body size \\ere determined. Pancreatic echo amplitude was both measured cliniealh• from the B-scan and evaluated in a blind review h v seven observers . The p·ancreases of cystic fibrosis could he distinguished oi1 the basis of echo amplitude with sensitivity and specificity of 94 per cent and 100 per cent for direct B-scan echo amplitude measurements and 74 per cent and 88 per cent for reviewers. Pancreatic size was of no value as a distinguishing characteristic, probably because as the diseased pancreas increases in echo amplitude b y fat and fibrous tissue replacement, it blends imperceptibly with the peripancreatic soft tissues. ~leasurement of pancreatic size in chronic pancreatitis is therelore inaccurate and probably over+ estimated. (Key words: pancreas. ; pancreatic echo amplitude; chronic pun~ creatis; cystic fibrosis)