Echographic features of a case of malignant intraocular medulloepithelioma

Owen, Rona I

doi:10.1136/bjo.2004.045203

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…Ultrasound biomicroscopy is a useful tool for evaluating lesions of the anterior segment of the eye. The UBM characteristics of medulloepitelioma described in this report are concordant with other studies: 8,11 a ciliary body mass with cystic areas and irregular internal reflectivity. This case illustrates the pattern of medulloepithelioma evaluated with UBM, and the correlation with histopathology.…”

Section: Discussionsupporting

confidence: 92%

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Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation

Ayres

Brasil

Klejnberg

et al. 2006

Clinical Exper Ophthalmology

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A 3-year-old girl presented with a distorted pupil and decrease of visual acuity. A ciliary body mass at the superior-temporal quadrant could be seen at slit-lamp examination. Ultrasound biomicroscopy revealed a lesion with lobulated surface, arising at the ciliary body, composed of compact and cystic areas. An iridocyclectomy was performed but the tumour recurred after a few months. The eye was then enucleated. Histopathologic evaluation showed sheets and cords of proliferated medullary epithelium. Cystic spaces and Flexner-Wintersteiner rosettes were also seen. Those findings correlated well with ultrasound biomicroscopic images. The knowledge of echographic characteristics can significantly assist in the diagnosis of medulloepithelioma of the ciliary body.

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Section: Discussionsupporting

confidence: 92%

“…There have been few studies about the echographic features of meduloepithelioma 8–11 . The purpose of this study is to report a case of benign non‐teratoid medulloepithelioma using ultrasound biomicroscopy (UBM) and correlate these images with surgical and histopathologic features.…”

Section: Introductionmentioning

confidence: 99%

Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation

Ayres

Brasil

Klejnberg

et al. 2006

Clinical Exper Ophthalmology

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“…A total of 65 studies involving 97 children with medulloepithelioma of the CB were considered eligible for inclusion in this review and we added our present case, with a total of 98 cases summarized in Table 1 . [ 2 , 4 , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] ] The other 3 cases series that were not included in the analysis are summarized in Table 2 for further information […”

Section: Discussionmentioning

confidence: 99%

An advanced case of pediatric ciliary body medulloepithelioma with detailed literature review

Alsulaiman,

AlThaqib,

Maktabi

et al. 2024

International Journal of Surgery Case Reports

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“…Standards of care do not exist. Large size or invasive medulloepitheliomas are commonly treated with primary enucleation [3,4,10,11]. Exenteration in combination with irradiation and/or adjuvant chemotherapy may be necessary in cases with orbital involvement [3,12].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of ciliary body medulloepithelioma with intraocular melphalan chemotherapy: a case report

et al. 2020

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Background Intraocular medulloepithelioma is commonly treated with primary enucleation. Conservative treatment options include brachytherapy, local resection and/or cryotherapy in selected cases. We report for the first time the use of targeted chemotherapy to treat a ciliary body medulloepithelioma with aqueous and vitreous seeding. Case presentation A 17-month-old boy with a diagnosis of ciliary body medulloepithelioma with concomitant seeding and neovascular glaucoma in the right eye was seen for a second opinion after parental refusal of enucleation. Examination under anesthesia showed multiple free-floating cysts in the pupillary area associated with iris neovascularization and a subluxated and notched lens. Ultrasound biomicroscopy revealed a partially cystic mass adjacent to the ciliary body between the 5 and 9 o’clock meridians as well as multiple nodules in the posterior chamber invading the anterior vitreous inferiorly. Fluorescein angiography demonstrated peripheral retinal ischemia. Left eye was unremarkable. Diagnosis of intraocular medulloepithelioma with no extraocular invasion was confirmed and conservative treatment initiated with combined intracameral and intravitreal melphalan injections given according to the previously described safety-enhanced technique. Ciliary tumor and seeding totally regressed after a total of 3 combined intracameral (total dose 8.1 μg) and intravitreal (total dose 70 μg) melphalan injections given every 7–10 days. Ischemic retina was treated with cryoablation as necessary. Three years later, ab interno trabeculotomy followed by 360° gonioscopy-assisted transluminal trabeculotomy 6 months later was performed for uncontrolled intraocular pressure despite antihypertensive drugs combined to cyclophotocoagulation and 7 intravitreal anti-VEGF injections for recurrent iris neovascularization. Cataract was removed at the same operative time. The child has remained disease- and metastasis-free at a 5-year follow-up since the last melphalan injection (25-month follow-up after the combined lensectomy-trabeculotomy) with a controlled intraocular pressure under topical quadritherapy and a best corrected Snellen visual acuity of 0.08. Conclusions We report for the first time complete regression of a non-infiltrating ciliary body medulloepithelioma with seeding achieved with only a small number of intracameral and intravitreal melphalan injections. Concomitant secondary neovascular glaucoma and cataract needed appropriate management to allow long-term eye and vision preservation.

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Echographic features of a case of malignant intraocular medulloepithelioma

Cited by 7 publications

References 5 publications

Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation

Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation

An advanced case of pediatric ciliary body medulloepithelioma with detailed literature review

Successful treatment of ciliary body medulloepithelioma with intraocular melphalan chemotherapy: a case report

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