Eco-corona formation on the nanomaterials in the aquatic systems lessens their toxic impact: A comprehensive review

Natarajan, Lokeshwari; Jenifer, M. Annie; Mukherjee, Amitava

doi:10.1016/j.envres.2020.110669

Cited by 47 publications

(34 citation statements)

References 71 publications

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“…Proteins from the organisms excretions combine with natural colloids to create a microenvironment that subsequently alters ENM uptake and toxicity. 43,51,[54][55][56] Proteins within the eco-corona are identifiable and linked to biochemical pathways to provide a unique window into biological response.…”

Section: Corona Formation Outside Of An Organismmentioning

confidence: 99%

“…Since ENMs trigger a change in biomolecular secretion when entering an organism's microenvironment, characterisation of eco-corona proteins illuminates stimulation of organismal pathways by ENMs and provides insight into the ENM fate and toxicity 56,57 (Figure 3). Given the combined importance of ENM transformations and organismal response, the study of eco-coronas highlights the importance of in situ characterisation.…”

Section: Corona Formation Outside Of An Organismmentioning

confidence: 99%

“…10 As the ENM nears an organism, an eco-corona forms, including a complex mixture of polysaccharides, proteins, lipids, nucleic acids and other biological molecules excreted/secreted by the organism. 10,50,51,56 This eco-corona is most likely composed predominantly of proteins, although the complete corona will also include lipids and metabolites. 11 Similar to recent work in the biomedical corona arena, expansion to characterisation of other biomolecules within the corona is key, including lipids, 67 polysaccharides, 65 and metabolites, 11,12,52 since they appear to also influence the ENM biological identity.…”

Section: Despite These Challenges Corona Characterisation Can Still P...mentioning

confidence: 99%

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Environmental dimensions of the protein corona

et al. 2021

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The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical, and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily on biomedical applications and human toxicity. The relevance of the environmental dimensions of the protein corona are still emerging. Often referred to as the eco-corona, a biomolecular coating forms upon nanomaterials as they enter the environment and may include proteins, as well as a diverse array of other biomolecules such as metabolites from cellular activity and/or natural organic matter. Proteins remain central in studies of eco-coronas because of the ease of monitoring and structurally characterising proteins, as well as their crucial role in receptor engagement and signaling. The proteins within the eco-corona are optimal targets to establish the biophysicochemical principles of corona formation and transformation, as well as downstream impacts on nanomaterial uptake, distribution, and impacts on the environment. Moreover, proteins appear to impart a biological identity leading to cellular or organismal recognition of nanomaterials, a unique characteristic in comparison to natural organic matter. We contrast insights into protein corona formation from clinical samples with those in environmentally relevant systems. Principles specific to the environment are also explored to gain insights into dynamics of interaction with / exchange by other biomolecules, including changes during trophic transfer and ecotoxicity. With many challenges remaining, we also highlight key opportunities for method development and impactful systems on which to focus the next phase of eco-corona studies. By interrogating these environmental dimensions of the protein corona, we offer a perspective on how mechanistic insights into protein coronas in the environment can lead to more sustainable, environmentally safe nanomaterials, as well as enhance the efficacy of nanomaterials used in remediation and in the agri-sector.

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Section: Corona Formation Outside Of An Organismmentioning

confidence: 99%

Section: Corona Formation Outside Of An Organismmentioning

confidence: 99%

Section: Despite These Challenges Corona Characterisation Can Still P...mentioning

confidence: 99%

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Environmental dimensions of the protein corona

et al. 2021

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“…For example, several health hazards are involved in the utilization of certain nanomaterials. Several studies have examined the negative effects of nanomaterials on human health and on the surroundings [152][153][154][155][156]. Figure 11 presents the potential exposure routes during the complete cycle of construction nanomaterials.…”

Section: Environmental and Health Concerns Of Nanomaterials Applications In Construction Industriesmentioning

confidence: 99%

Recent Advancements in the Nanomaterial Application in Concrete and Its Ecological Impact

2021

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At present, nanotechnology is a significant research area in different countries, owing to its immense ability along with its economic impact. Nanotechnology is the scientific study, development, manufacturing, and processing of structures and materials on a nanoscale level. It has tremendous application in different industries such as construction. This study discusses the various progressive uses of nanomaterials in concrete, as well as their related health risks and environmental impacts. Nanomaterials such as nanosilica, nano-TiO2, carbon nanotubes (CNTs), ferric oxides, polycarboxylates, and nanocellulose have the capability to increase the durability of buildings by improving their mechanical and thermal properties. This could cause an indirect reduction in energy usage and total expenses in the concrete industry. However, due to the uncertainties and irregularities in size, shape, and chemical compositions, some nanosized materials might have harmful effects on the environment and human health. Acknowledgement of the possible beneficial impacts and inadvertent dangers of these nanosized materials to the environment will be extremely important when pursuing progress in the upcoming years. This research paper is expected to bring proper attention to the probable effects of construction waste, together with the importance of proper regulations, on the final disposal of the construction waste.

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“…It should be noted that one of the hottest issues in nanotoxicology is the development of predictive models for the risk assessment of NPs [21][22][23][24]. The toxicity of NPs in combinations with chemicals [25], metallic pollutants [26], natural organic matter [27], other pollutants, and environmental substances [28] are some of the major concerns of environmental nanotoxicology. Another important problem is the lack of understanding of the mechanisms of interaction between different NPs.…”

Section: Introductionmentioning

confidence: 99%

Individual and Binary Mixture Toxicity of Five Nanoparticles in Marine Microalga Heterosigma akashiwo

Pikula

Johari

Santos-Oliveira

et al. 2022

IJMS

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The investigation of the combined toxic action of different types of nanoparticles (NPs) and their interaction between each other and with aquatic organisms is an important problem of modern ecotoxicology. In this study, we assessed the individual and mixture toxicities of cadmium and zinc sulfides (CdS and ZnS), titanium dioxide (TiO2), and two types of mesoporous silicon dioxide (with no inclusions (SMB3) and with metal inclusions (SMB24)) by a microalga growth inhibition bioassay. The counting and size measurement of microalga cells and NPs were performed by flow cytometry. The biochemical endpoints were measured by a UV-VIS microplate spectrophotometer. The highest toxicity was observed for SMB24 (EC50, 3.6 mg/L) and CdS (EC50, 21.3 mg/L). A combined toxicity bioassay demonstrated that TiO2 and the SMB3 NPs had a synergistic toxic effect in combinations with all the tested samples except SMB24, probably caused by a “Trojan horse effect”. Sample SMB24 had antagonistic toxic action with CdS and ZnS, which was probably caused by metal ion scavenging.

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Eco-corona formation on the nanomaterials in the aquatic systems lessens their toxic impact: A comprehensive review

Cited by 47 publications

References 71 publications

Environmental dimensions of the protein corona

Environmental dimensions of the protein corona

Recent Advancements in the Nanomaterial Application in Concrete and Its Ecological Impact

Individual and Binary Mixture Toxicity of Five Nanoparticles in Marine Microalga Heterosigma akashiwo

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