Eco-friendly polyethylene glycol-400: a rapid and efficient recyclable reaction medium for the synthesis of thiazole derivatives

Novel thiazolo-pyrazolyl derivatives as xanthine oxidase inhibitors and free radical scavengers

“…PEG is nontoxic, non-halogenated, inexpensive potentially recyclable and water soluble which facilitate its removal from reaction product. With our recent success on the development of new selective environmentally friendly methodologies using polyethylene glycol (PEG-400) [44,45] as a solvent for the preparation of biologically active compounds, herein we reported the synthesis of 26 substituted thiazolo-pyrazolyl derivatives V(a-z). Out of 26 synthesized, derivatives Vq, Vo, Vx, Vu, Vk, Vg, Vh, Vf and Ve showed activity against XO based on IC 50 values represented in Table 2.…”

“…Y-700 (10) [19] N-aryl-5-amino-4-cyanopyrazole (11) [20], flavonoids (12) [21], anacardic acid (13) [22] and curcumin (14) [23] also reported to be potent xanthine oxidase inhibitor. Our consistent work on heterocycles [24][25][26] having potent biological activities, prompted us to prepare new thiazolopyrazolyl derivatives bearing different functional moieties and expected to possess potent XO inhibitory activity comparable to Allopurinol along with antioxidant effect.…”

Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

“…In parallel, use of green solventmediated reactions is a further concern in sustainable development. Owing to these concerns, polyethylene glycol-400 (PEG-400) has received considerable attention over the last two decades due to its unique environmentally benign characteristics [38][39][40][41][42][43][44][45], motivating our use of PEG-400 as an alternative, green solvent in the present study.…”

Comparative Molecular Docking Of Xanthine Oxidases: In Silico Study of Inhibition of Xanthine Oxidase by Synthetic (2nap1-2nap5) Series As Drug Compound In Parkinson’s Disease

“…DISCUSSION Our research of interest gives importance to the synthesis of NAP series compound i.e 1-acetyl5-[3-(4-substitutedphenyl)-1-phenyl-1H-pyrazol-4yl]-3-(4-fluorophenyl)-4, 5-dihydro-1H-pyrazole, in PEG 400 [18][19][20] and docking it with xanthine oxidase. As we introduce about P.D is the second most common neurodegenerative disease.…”

“…Organic synthesis in PEG under low to moderate temperature condition is an area of significance in green organic synthesis. Considering these reports the development of new synthetic strategy for biologically active compounds, herein we report the synthesis of fluoro substituted N-acetyl pyrazoline derivative of pyrazole chalcones in PEG-400 [18][19][20] . Our consistent work on heterocyclic compound having potent biological activities prompted us to prepare a new series of fluoro substituted pyrazolyl pyrazolines (2NAP1-2NAP5) derivatives bearing different functional moieties and expected to posses potent xo inhibitory activity comparable to standard antioxidant compound.…”