Eco-friendly synthesis of 1,4-benzodiazepine-2,5-diones in the ionic liquid [bmim]Br

Improved Method for Microwave-Assisted Synthesis of Benzodiazepine-2,5-diones from Isatoic Anhydrides Mediated by Glacial Acetic Acid

“…Benzodiazepin-2,5-diones 3-8 were identified by comparison of IR, NMR, and electron impact mass spectrometry (EIMS) data with those published in the literature. [9][10][11]15,23 As mentioned above, benzodiazepines participate in important biological activities, and analogues with groups, such as iodine in the aromatic system would modify the structure and, consequently, their properties will be affected. Preparation of new molecules with improved properties is of current importance.…”

“…6,7 A variation of this method is the use of isatoic anhydride (1) instead of anthranilic acid with very similar results. [8][9][10][11] Benzodiazepin-2,5-dione have been synthesized using solid phase approach, however, this method has some limitations; for example, the alkylation on the nitrogen of an amide reduces the number of alkylating agents available. [12][13][14][15][16][17] The use of microwave irradiation as activating mode for the synthesis of organic compounds 18 has increased considerably in recent times.…”