Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under solvent-free solid-state conditions and their antimicrobial activity

Sakram, B.; Sonyanaik, B.; Ashok, K.; Rambabu, S.; Ravi, D.; Kurumanna, A.; Shyam, Perugu

doi:10.1007/s11164-016-2736-z

Cited by 22 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sakram et al [54] in 2017 investigated the green synthetic procedure for the preparation of 2-(2-(3-nitrophenyl)-1,8-naphthyridin-3-yl)-5-aryl-1,3,4-oxadiazole derivatives. They prepared the compounds by grinding method which is non-hazardous, eco-friendly, provides good yield in short reaction time and no special apparatus is required.…”

Section: Synthesis Of 134-oxadiazole Derivatives By Grinding Methodmentioning

confidence: 99%

A Review on the Preparation of 1,3,4-Oxadiazoles From the Dehydration of Hydrazines and Study of Their Biological Roles

Nayak

Poojary

2019

Chemistry Africa

View full text Add to dashboard Cite

Heterocyclic chemistry is the interesting area for the effective approach and for the invention of biologically active 1,3,4-oxadiazole cores. 1,3,4-Oxadiazole is a five membered heterocyclic ring which plays key role in the development of new medicinal species for the treatment of numerous diseases. Hence, nowadays researchers have developed the innovative methods for the synthesis of 1,3,4-oxadiazole derivatives and their medicinal applications. Therefore, results of recent developments in the synthesis and biological applications of 1,3,4-oxadiazole candidates over the past 15 years (2005-2019) are reviewed in the present article. The information in the present article may be useful to many researchers which lead to exploration of new therapeutic species for the society.

show abstract

Section: Synthesis Of 134-oxadiazole Derivatives By Grinding Methodmentioning

confidence: 99%

A Review on the Preparation of 1,3,4-Oxadiazoles From the Dehydration of Hydrazines and Study of Their Biological Roles

Nayak

Poojary

2019

Chemistry Africa

View full text Add to dashboard Cite

show abstract

“…[12][13][14][15][16] In prolongation, of our foregoing studies on the development of green methodologies and biologically active compounds. [17][18][19][20][21] We report here in a facile and convenient synthetic strategy for the preparation of 4-aryl tetrazolo[1,5-a][1,8]naphthyridine derivatives in the presence of simple glacial acetic acid formed high yield and these compounds showed interesting antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly green construction of 4-Aryl-tetrazolo-[1,5-a][1,8]naphthyridine scaffolds and their in vitro anti-microbial and molecular modeling studies

Sonyanaik

Ravi

Shyam³

et al. 2023

Preprint

View full text Add to dashboard Cite

An efficient eco-friendly synthesis of 4-aryl tetrazolo[1,5-a][1,8]naphthyridine derivatives have been successfully prepared through microwave method in short reaction time. The microwave method has unique advantages, short reaction time, easy workup procedure, and simple purification of the products. Synthesized the entire molecule evaluated for their antimicrobial activity among them compounds 6g and 6a demonstrated highest anti-microbial activity. Moreover, in silico molecular modeling evaluation has done by considering docking scores, hydrogen bond interactions, affinity, and the short distance between ligand and receptor. All the molecules good docking results have shown that binding interactions with the target protein and obtained results were well complemented to the antimicrobial activity.

show abstract

“…Synthesis of fluorinated naphthyridines has been demonstrated many times (for selected examples, see Scheme ). , Although many methods have been developed for direct fluorination of azaheterocycles, direct functionalization of naphthyridine using transition-metal-catalyzed processes remains challenging due to its ability to strongly bind transition metals and suppress their catalytic performance. Therefore, there is a need for a new and practical approach to the synthesis of fluorinated naphthyridines.…”

Section: Introductionmentioning

confidence: 99%

NHC–BIAN–Cu(I)-Catalyzed Friedländer-Type Annulation of 2-Amino-3-(per)fluoroacetylpyridines with Alkynes on Water

et al. 2022

View full text Add to dashboard Cite

The direct catalytic alkynylation/dehydrative cyclization of 2-amino-3-trifluoroacetyl-pyridines on water was developed for the efficient synthesis of a broad range of fluorinated 1,8-naphthyridines from terminal alkynes. A novel N-heterocyclic carbene (NHC) ligand system that combines a π-extended acenaphthylene backbone with sterically bulky pentiptycene pendant groups was successfully utilized in a copper- or silver-mediated cyclization. Computational analysis of the reaction pathway supports our explanation of the different experimental conversions and yields for the set of copper and silver catalysts. The impact of steric hindrance at the metal center and the flexibility of substituents on the imidazole ring of the NHC on catalytic performance are also discussed.

show abstract

Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under solvent-free solid-state conditions and their antimicrobial activity

Cited by 22 publications

References 27 publications

A Review on the Preparation of 1,3,4-Oxadiazoles From the Dehydration of Hydrazines and Study of Their Biological Roles

A Review on the Preparation of 1,3,4-Oxadiazoles From the Dehydration of Hydrazines and Study of Their Biological Roles

Eco-friendly green construction of 4-Aryl-tetrazolo-[1,5-a][1,8]naphthyridine scaffolds and their in vitro anti-microbial and molecular modeling studies

NHC–BIAN–Cu(I)-Catalyzed Friedländer-Type Annulation of 2-Amino-3-(per)fluoroacetylpyridines with Alkynes on Water

Contact Info

Product

Resources

About