Abstract:Background:
Agro-waste derived solvent media act as a greener process for the peptide bond formation using Nα
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Fmoc-amino acid chloride and amino acid ester salt with in situ neutralization and coupling under biphasic condition. The
Fmoc-amino acid chlorides are prepared by the reported procedure of freshly distilled SOCl2 with dry CH2Cl2. The protocol
found many added advantages such as neutralization of amino acid ester salt and not required additional base for the neutralization, and directly coupling tak… Show more
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