Eco‐oncology: Applying ecological principles to understand and manage cancer

Oli, Monika W.; Oli, Madan K.

doi:10.1002/ece3.6590

Cited by 32 publications

(29 citation statements)

References 172 publications

(209 reference statements)

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“…The cancer microenvironment is similar to an ecological system, a mixture with distinct cellular populations and species (Figure 4A). The establishment and growth of tumours are strikingly similar to an adaptive and evolving ecosystem 132 . For example, the species richness, which can also be referred to intra tumour heterogeneity, is potentially linked with immunotherapy robustness and patients’ long‐term outcome 133,134 .…”

Section: Spatial Tumour Ecology: Toward a New Research Paradigmmentioning

confidence: 99%

Spatial omics: Navigating to the golden era of cancer research

Cheng

Wang

et al. 2022

Clinical & Translational Med

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The idea that tumour microenvironment (TME) is organised in a spatial manner will not surprise many cancer biologists; however, systematically capturing spatial architecture of TME is still not possible until recent decade. The past five years have witnessed a boom in the research of high‐throughput spatial techniques and algorithms to delineate TME at an unprecedented level. Here, we review the technological progress of spatial omics and how advanced computation methods boost multi‐modal spatial data analysis. Then, we discussed the potential clinical translations of spatial omics research in precision oncology, and proposed a transfer of spatial ecological principles to cancer biology in spatial data interpretation. So far, spatial omics is placing us in the golden age of spatial cancer research. Further development and application of spatial omics may lead to a comprehensive decoding of the TME ecosystem and bring the current spatiotemporal molecular medical research into an entirely new paradigm.

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Section: Spatial Tumour Ecology: Toward a New Research Paradigmmentioning

confidence: 99%

Spatial omics: Navigating to the golden era of cancer research

Cheng

Wang

et al. 2022

Clinical & Translational Med

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“…The eco-evolutionary dynamics is exceptionally robust against therapeutic disturbances (perturbations) for three reasons: (1) the cellular diversity (spatial heterogeneity) in the genotypic and phenotypic properties of tumor cells; (2) variations in the tumor environment, dominantly governed by variations in blood flow; (3) response and resistance of cancer cells are shaped by their complex interactions with adjacent host cells, including immune and microbiome cells. Horning, 2017;Gatenby and Brown, 2018;Reynolds et al, 2020 Cancer (cells) vs. X-species | metastasis is similar to speciation in evolution, to migration and invasion in ecology.…”

Section: No Key Concepts/hypotheses In Cancer Ecologymentioning

confidence: 99%

Ecology of Human Medical Enterprises: From Disease Ecology of Zoonoses, Cancer Ecology Through to Medical Ecology of Human Microbiomes

Sam

Zhang²

2022

Front. Ecol. Evol.

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In nature, the interaction between pathogens and their hosts is only one of a handful of interaction relationships between species, including parasitism, predation, competition, symbiosis, commensalism, and among others. From a non-anthropocentric view, parasitism has relatively fewer essential differences from the other relationships; but from an anthropocentric view, parasitism and predation against humans and their well-beings and belongings are frequently related to heinous diseases. Specifically, treating (managing) diseases of humans, crops and forests, pets, livestock, and wildlife constitute the so-termed medical enterprises (sciences and technologies) humans endeavor in biomedicine and clinical medicine, veterinary, plant protection, and wildlife conservation. In recent years, the significance of ecological science to medicines has received rising attentions, and the emergence and pandemic of COVID-19 appear accelerating the trend. The facts that diseases are simply one of the fundamental ecological relationships in nature, and the study of the relationships between species and their environment is a core mission of ecology highlight the critical importance of ecological science. Nevertheless, current studies on the ecology of medical enterprises are highly fragmented. Here, we (i) conceptually overview the fields of disease ecology of wildlife, cancer ecology and evolution, medical ecology of human microbiome-associated diseases and infectious diseases, and integrated pest management of crops and forests, across major medical enterprises. (ii) Explore the necessity and feasibility for a unified medical ecology that spans biomedicine, clinical medicine, veterinary, crop (forest and wildlife) protection, and biodiversity conservation. (iii) Suggest that a unified medical ecology of human diseases is both necessary and feasible, but laissez-faire terminologies in other human medical enterprises may be preferred. (iv) Suggest that the evo-eco paradigm for cancer research can play a similar role of evo-devo in evolutionary developmental biology. (v) Summarized 40 key ecological principles/theories in current disease-, cancer-, and medical-ecology literatures. (vi) Identified key cross-disciplinary discovery fields for medical/disease ecology in coming decade including bioinformatics and computational ecology, single cell ecology, theoretical ecology, complexity science, and the integrated studies of ecology and evolution. Finally, deep understanding of medical ecology is of obvious importance for the safety of human beings and perhaps for all living things on the planet.

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“…Двумя годами ранее в сугубо онкологическом, более того, ориентированном на практику журнале «Cancer Control" («Контроль раковых заболеваний») вышел тематический номер под названием «Экологические и эволюционные подходы к контролю раковых заболеваний» с редакционной статьей, дополняющей в ее заголовке название тематики словами «Онкология обрела концептуальный дом родной» [68]. Тогда же в журнале "Ecology and Evolution" (Экология и эволюция) был опубликован обзор, в котором для обозначения этой проблематики был введен термин эко-онкология [58].…”

Section: Introductionunclassified

Общие Принципы Взаимоотношений Живых Организмов С Экосистемой И Злокачественных Клеток С Живым Организмом

Голубев¹

2022

Biosfera

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The present review addresses studies based on behavioral similarities between cancer cells in a metazoan organism and unicellular organisms in an ecosystem and between malignant tumors and some primordial colonial forms of life, from which metazoans evolved. Unicellular organisms and their colonies can exist only by compensating for their losses by the proliferation of remaining cells. Therefore, proliferation or readiness to proliferate is a priority for cells. Metazoans evolution was associated with increasing the stringency of the control of this priority. In this perspective, the common set of cancer hallmarks, which emerges in the courses of progression of different cancers, which feature different initial combinations of mutations in oncogenes and antioncogenes and exist under different initial conditions possible in various organs, results not from the convergent evolution but rather from the recapitulation of the evolutionary primordial mode of cell life. The malignant transformation is a manifestation of the disinhibition of a gestalt of traits required for the survival of cell populationin an ecosystem, which is what a tumor host eventually turns to for the tumor. Such ecological attitudes to malignant growth suggest analogies betweenthe therapeutic resistance of cancer with the resistance of pests to pesticides or of bacteria to antibiotics and between metastases and invasive species. An important means used by unicellular organisms to survive in noxious conditions is increasing the rate of mutation to produce different variants, among which some may happen to fit the current situation. This is what occurs upon cancer therapy, which increases the genetic diversity of cancer cells and acts as a factor of the positive selection of cells for resistance to the very same therapy. Because the resulting cell clones compete for body resources, the elimination of the cells that respond to therapy is favorable for the cells that are resistant to it. Therefore, it is unwise to use chemotherapy for tumor elimination. It is more prudent to aim at achieving a balance of cancer cell populations, which makes it possible to turn cancer into a chronic rather than fatal disease. These arguments justify the current efforts to develop regiments of the so-called adaptive therapy for cancer.

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Eco‐oncology: Applying ecological principles to understand and manage cancer

Cited by 32 publications

References 172 publications

Spatial omics: Navigating to the golden era of cancer research

Spatial omics: Navigating to the golden era of cancer research

Ecology of Human Medical Enterprises: From Disease Ecology of Zoonoses, Cancer Ecology Through to Medical Ecology of Human Microbiomes

Общие Принципы Взаимоотношений Живых Организмов С Экосистемой И Злокачественных Клеток С Живым Организмом

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