(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future

Schuijt, Lara M.; Feng, Peng; Berg, Sanne van den; Dingemans, Milou M.L.; Brink, Paul J. Van den

doi:10.1016/j.scitotenv.2021.148776

Cited by 90 publications

(42 citation statements)

References 148 publications

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“…There is increasing recognition that effects-based monitoring is necessary to understand environmental risk of chemical exposure and other environmental stressors (Dubé and Munkittrick 2001 ; Sanchez and Porcher 2009 ; Ekman et al 2013 ; Schuijt et al 2021 ), primarily due to the increasing (and often unmeasured) chemicals and mixture effects. Long-term monitoring at various levels of biological organization can assist in distinguishing natural variation and low-level effects of environmental stressors (Sandström et al 2005 ), providing management agencies with knowledge of temporal variation, allowing them to identify trends (Lohner and Dixon 2013 ), recurring patterns (Flinders et al 2015 ) and actions for mitigating identified risks.…”

Section: Resultsmentioning

confidence: 99%

A case study: temporal trends of environmental stressors and reproductive health of smallmouth bass (Micropterus dolomieu) from a site in the Potomac River Watershed, Maryland, USA

et al. 2022

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Decades of poor reproductive success and young-of-the-year survival, combined with adult mortality events, have led to a decline in the smallmouth bass (SMB; Micropterus dolomieu) population in sections of the Potomac River. Previous studies have identified numerous biologic and environmental stressors associated with negative effects on SMB health. To better understand the impact of these stressors, this study was conducted at the confluence of Antietam Creek and the Potomac River from 2013 to 2019 to identify temporal changes associated with SMB reproductive health. Surface water samples were collected and analyzed for over 300 organic contaminants, including pesticides, phytoestrogens, pharmaceuticals, hormones and total estrogenicity (E2Eq). Adult SMB were collected and sampled for multiple endpoints, including gene transcripts associated with reproduction (molecular), histopathology (cellular), and organosomatic indices (tissue). In males, biomarkers of estrogenic endocrine disruption, including testicular oocytes (TO) and plasma vitellogenin (Vtg) were assessed. Numerous agriculture-related contaminants or land use patterns were associated with gene transcript abundance in both male and female SMB. Positive associations between pesticides in the immediate catchment with TO severity and E2Eq with plasma Vtg in males were identified. In males, the prevalence of TO and detectable levels of plasma Vtg, liver vitellogenin transcripts (vtg) and testis vtg were high throughout the study. Peaks of complex mixtures of numerous contaminants occurred during the spring/early summer when spawning and early development occurs and to a lesser extent in fall/winter during recrudescence. Management practices to reduce exposure during these critical and sensitive periods may enhance reproductive health of these economically important sportfishes.

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Section: Resultsmentioning

confidence: 99%

A case study: temporal trends of environmental stressors and reproductive health of smallmouth bass (Micropterus dolomieu) from a site in the Potomac River Watershed, Maryland, USA

et al. 2022

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“…Thus, chemical-driven changes in an individual mammal can persist longer than changes in (meta-) communities of microorganisms. Accordingly, temporal and spatial scales of (eco)toxicological test methods, of species traits and of stressors are interrelated, resulting in several species groups being underrepresented in certain test methods (Schuijt et al, 2021). For example, in vitro bioassays have been realised mainly for mammalian cell lines, whereas whole organism tests as well as biomarkers mainly for selected fish and invertebrate species (Schuijt et al, 2021).…”

Section: The Scope Of Pred I C Ti On-a Que S Ti On Of Sc Alementioning

confidence: 99%

Three perspectives on the prediction of chemical effects in ecosystems

Schneeweiss

Juvigny‐Khenafou

Osakpolor

et al. 2022

Global Change Biology

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The increasing production, use and emission of synthetic chemicals into the environment represents a major driver of global change. The large number of synthetic chemicals, limited knowledge on exposure patterns and effects in organisms and their interaction with other global change drivers hamper the prediction of effects in ecosystems. However, recent advances in biomolecular and computational methods are promising to improve our capacity for prediction. We delineate three idealised perspectives for the prediction

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“…Increasing concentrations of chemical pollutants, including heavy metals and organic pollutants from anthropogenic activities, have significantly affected aquatic ecosystems by inhibiting cellular function and growth of aquatic organisms and even killing organisms [ 1 , 2 , 3 ]. Numerous ecological risk assessments have been conducted for various individual chemical pollutants [ 4 , 5 ]. However, the need to assess risks for combinations of chemicals has become apparent since organisms are exposed to mixtures of chemical pollutants in natural environments rather than individual compounds, especially in aquatic ecosystems [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity Effects of Combined Mixtures of BDE-47 and Nickel on the Microalgae Phaeodactylum tricornutum (Bacillariophyceae)

Shi

Guo

et al. 2022

Toxics

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Nickel and 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) are two environmental pollutants commonly and simultaneously present in aquatic systems. Nickel and BDE-47 are individually toxic to various aquatic organisms. However, their toxicity mechanisms are species-dependent, and the toxic effects of combined mixtures of BDE-47 and nickel have not yet been investigated. The present study investigated the toxic effects of combined mixtures of BDE-47 and nickel in the diatom Phaeodactylum tricornutum. BDE-47 and nickel mixtures significantly decreased cell abundance and photosynthetic efficiency, while these cells’ reactive oxygen species (ROS) production significantly increased. The EC50-72 h for BDE-47 and mixtures of BDE-47 and nickel were 16.46 ± 0.93 and 1.35 ± 0.06 mg/L, respectively. Thus, combined mixtures of the two pollutants enhance their toxic effects. Interactions between BDE-47 and nickel were evaluated, revealing synergistic interactions that contributed to toxicity in P. tricornutum. Moreover, transcriptomic analyses revealed photosynthesis, nitrogen metabolism, the biosynthesis of amino acids, the biosynthesis of secondary metabolites, oxoacid metabolism, organic acid metabolism, carboxylic acid metabolism, and oxidation-reduction processes were considerably affected by the mixtures. This study provides evidence for the mechanisms of toxicity from combined BDE-47 and nickel exposure while also improving our understanding of the ecological risks of toxic chemicals on microalgae.

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(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future

Cited by 90 publications

References 148 publications

A case study: temporal trends of environmental stressors and reproductive health of smallmouth bass (Micropterus dolomieu) from a site in the Potomac River Watershed, Maryland, USA

A case study: temporal trends of environmental stressors and reproductive health of smallmouth bass (Micropterus dolomieu) from a site in the Potomac River Watershed, Maryland, USA

Three perspectives on the prediction of chemical effects in ecosystems

Toxicity Effects of Combined Mixtures of BDE-47 and Nickel on the Microalgae Phaeodactylum tricornutum (Bacillariophyceae)

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