Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics

Zhang, Lijuan; Lu, Qian; Lee, Ding; Wang, Lei; Wong, Ming Hung; Tao, Hu-Chun

doi:10.1016/j.ese.2021.100081

Cited by 62 publications

(19 citation statements)

References 214 publications

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“…Metabolomics can also be applied as a diagnostic strategy to identify metabolic signatures (or biomarkers) specific to a given stressor or physiological or pathological state, which could be used in predictive models [45]. Such biomarkers may be suitable aquatic biomonitoring tools for generating early warning signals of environmental disturbances [8]. In environmental metabolomics, several authors focused on the identification of (potential) biomarkers in response to PhAC exposure.…”

Section: Meoa Biomarkers To Enhance Environmental Biomonitoringmentioning

confidence: 99%

“…Since the early 21st century, scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. Numerous reviews on environmental metabolomics have underlined the high potential of this approach: (i) to gain insight into the specific mechanisms of action (MeOAs) through which contaminants achieve adverse outcomes at higher biological organization levels (e.g., cellular, organ, and individual) in comprehensive hazard or risk assessments, and (ii) to develop robust metabolic biomarkers of effects or exposure as an environmental biomonitoring tool [1][2][3][4][5][6][7][8]. This potential is based on the fact that metabolomics has the advantage of providing a high sensitivity (i.e., low levels of metabolites can be measured), high assessment efficiency (i.e., a broad range of metabolites may be measured without a priori), and comprehensive evaluation (i.e., provides an overview of molecular effects, reflecting the physiological status of the organism) [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

et al. 2022

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Scientists often set ambitious targets using environmental metabolomics to address challenging ecotoxicological issues. This promising approach has a high potential to elucidate the mechanisms of action (MeOAs) of contaminants (in hazard assessments) and to develop biomarkers (in environmental biomonitoring). However, metabolomics fingerprints often involve a complex mixture of molecular effects that are hard to link to a specific MeOA (if detected in the analytical conditions used). Given these promises and limitations, here we propose an updated review on the achievements of this approach. Metabolomics-based studies conducted on the effects of pharmaceutical active compounds in aquatic organisms provide a relevant means to review the achievements of this approach, as prior knowledge about the MeOA of these molecules could help overcome some shortcomings. This review highlighted that current metabolomics advances have enabled more accurate MeOA assessment, especially when combined with other omics approaches. The combination of metabolomics with other measured biological endpoints has also turned out to be an efficient way to link molecular effects to (sub)-individual adverse outcomes, thereby paving the way to the construction of adverse outcome pathways (AOPs). Here, we also discuss the importance of determining MeOA as a key strategy in the identification of MeOA-specific biomarkers for biomonitoring. We have put forward some recommendations to take full advantage of environmental metabolomics and thus help fulfil these promises.

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Section: Meoa Biomarkers To Enhance Environmental Biomonitoringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

et al. 2022

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“…The recent advancement in omics approaches provides insights associated with the physiological and biochemical characteristic linked to the proliferation of these cyanobacteria. Environmental metabolomics approaches have been utilized to assess the organism–environment interactions at the molecular level to improve the understanding of their mode of action [ 33 , 34 ]. Through this application, identification of different metabolites assists in detecting alterations in certain metabolic pathways under environmental stresses [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Light and Temperature on the Metabolic Profiling of Two Habitat-Dependent Bloom-Forming Cyanobacteria

et al. 2022

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Rapid proliferation of cyanobacteria in both benthic and suspended (planktonic) habitats is a major threat to environmental safety, as they produce nuisance compounds such as cytotoxins and off-flavors, which degrade the safety and quality of water supplies. Temperature and light irradiance are two of the key factors in regulating the occurrence of algal blooms and production of major off-flavors. However, the role of these factors in regulating the growth and metabolism is poorly explored for both benthic and planktonic cyanobacteria. To fill this gap, we studied the effects of light and temperature on the growth and metabolic profiling of both benthic (Hapalosiphon sp. MRB220) and planktonic (Planktothricoides sp. SR001) environmental species collected from a freshwater reservoir in Singapore. Moreover, this study is the first report on the metabolic profiling of cyanobacteria belonging to two different habitats in response to altered environmental conditions. The highest growth rate of both species was observed at the highest light intensity (100 μmol photons/m²/s) and at a temperature of 33 °C. Systematic metabolite profiling analysis suggested that temperature had a more profound effect on metabolome of the Hapalosiphon, whereas light had a greater effect in the case of Planktothricoides. Interestingly, Planktothricoides sp. SR001 showed a specialized adaptation mechanism via biosynthesis of arginine, and metabolism of cysteine and methionine to survive and withstand higher temperatures of 38 °C and higher. Hence, the mode of strategies for coping with different light and temperature conditions was correlated with the growth and alteration in metabolic activities for physiological and ecological adaptations in both species. In addition, we putatively identified a number of unique metabolites with a broad range of antimicrobial activities in both species in response to both light and temperature. These metabolites could play a role in the dominant behavior of these species in suppressing competition during bloom formation. Overall, this study elucidated novel insights into the effects of environmental factors on the growth, metabolism, and adaptation strategies of cyanobacteria from two different habitats, and could be useful in controlling their harmful effects on human health and environmental concerns.

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“…Metabolomics in ecotoxicology generates high throughput data, providing information on alterations of specific metabolic pathways in response to environmental stress, including anthropogenic contaminants [ 1 ]. Metabolite changes have traditionally been primarily measured using nuclear magnetic resonance spectroscopy (NMR), but liquid chromatography, coupled with mass spectrometry (LC-MS)-based metabolomics, is now increasingly used, due to its higher sensitivity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although the number of metabolomics studies in ecotoxicology has drastically increased over the past 20 years, targeted and untargeted LC-MS-based metabolomics (in support of ecotoxicological studies) have primarily focused on assessing metabolite alterations in aquatic organisms exposed to a variety of chemicals [ 1 , 2 ]. For example, a targeted analysis reported that arginine, proline, alanine, aspartic acid, and glutamate metabolism were altered after PCB exposure in both zebrafish ( Danio rerio ) embryos and larvae [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

et al. 2021

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This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.

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Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics

Cited by 62 publications

References 214 publications

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Environmental Metabolomics Promises and Achievements in the Field of Aquatic Ecotoxicology: Viewed through the Pharmaceutical Lens

Effects of Light and Temperature on the Metabolic Profiling of Two Habitat-Dependent Bloom-Forming Cyanobacteria

Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

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