Studies on the influence of biologically active substances with immunomodulatory properties on the productivity of greenhouse cucumber were conducted in the winter-spring turnover of the sixth light zone in 2019-2020. The paper analyzes data on the prevalence of major diseases in cucumber plantings, the intensity of respiration and photosynthesis in plants, the level of yield and yielding of standard crop products, depending on the use of immunomodulating substances against the background of the main nutrition scheme. As a result of scientific research, it was found that the use of immunomodulators (arachidonic acid, hydroxycinnamic acids, triterpenic acids, salicylic acid) in the technology of cucumber cultivation activated the protective properties of plants against pathogens, contributed to the activation of the intensity of respiration, photosynthesis, obtaining an increased yields and the output of standard products.