Ecological level analysis of primary lung tumors in dogs and cats and environmental radon activity

Fowler, Brittany L; Johannes, Chad M.; O’Connor, Annette M.; Collins, Deanna; Lustgarten, Jonathan; Yuan, Chaohui; Weishaar, Kristen; Sullivan, Kelly; Hume, Kelly R.; Mahoney, Jennifer Luppens; Vale, Brittany; Schubert, Alicia G.; Ball, Valerie A.; Cooley-Lock, Katie; Curran, Kaitlin M.; Nafe, Laura; Gedney, Allison; Weatherford, Megan; LeVine, Dana N.

doi:10.1111/jvim.15936

Cited by 9 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our analysis focused on data with high level of aggregation, and no clear effect of geography variation at district level on malignancy appeared, after the data structure analyzed. The analysis also does not capture effects from narrower closer environmental factors, such as indoor pollution caused by various carcinogens such as tobacco, radon, and others, which may have a stronger influence on malignancy [ 59 , 60 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Pinello

Amorim

Pires

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (sex, age, and breed), topography, and geographic location using a mixed-effects logistic regression model. Cats had a higher proportion of malignant tumors (78.7%) than dogs (46.2%), and the malignancy profile was very different regarding tumors’ topographies. The mean age of malignant tumors occurred eight months later than benign ones (9.1, SD = 3.4; 9.8, SD = 3.2), in general. Species (OR = 3.96, 95%CI 3.57: 4.39) and topography (MOR = 4.10) were the two most important determinants of malignancy risk. Female dogs had a higher risk than male dogs (OR = 1.19, 95%CI 1.08: 1.31), which does not appear to be the case in cats (OR = 0.98, 95%CI 0.77: 1.23). Breed contributed significantly to differences in malignancy risk in dogs (MOR = 1.56), particularly in pit bulls and boxers. District of residence was not so relevant in predicting malignancy risk (MOR = 1.14). In both species, the risk of malignancy increased by approximately 20% every three years. It could be hypothesized that species differences in genetic structure may contribute to tumor malignancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Pinello

Amorim

Pires

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Apesar de o câncer ser mundialmente a principal causa de morte em homens e mulheres, as taxas de incidência e mortalidade variam em todo o mundo. Diversas variáveis socioeconômicas são capazes de influenciar na incidência do câncer de pulmão, tais como o acesso e qualidade do sistema de saúde, acesso aos métodos de diagnóstico precoce e tratamento direcionado, acesso a informação e conscientização acerca dos fatores de risco, hábitos culturais, exposição ocupacional, alimentação, fatores genéticos, entre outros (BARTA et al, 2019;FOWLER et al, 2020;INCA, 2021).…”

Section: Discussionunclassified

“…A formação de uma neoplasia se inicia a partir da alteração genética herdada ou adquirida, sendo a última gerada espontaneamente ou induzida por processos endógenos ou exógenos. Isto pode ocorrer através da exposição a radiações ionizantes, vírus oncogênicos e substâncias químicas como arsênico, asbesto, berílio, cromo, radônio, urânio, níquel, cádmio, cloreto de vinila e éter de clorometil (UEHARA et al, 1998;KUSEWITT e RUSH, 2009;KUMAR et al, 2013;BADE et al, 2020;FOWLER et al,2020). Ainda, estudos revelam a existência de células iniciadoras tumorais que participam na carcinogênese e conferem ao tumor resistência à quimioterapia (SULLIVAN et al, 2010;ZAKARIA et al, 2018).…”

Section: Neoplasias Pulmonaresunclassified

See 1 more Smart Citation

>b<Estudo comparativo de neoplasias pulmonares primárias em cães e humanos>/b<

Dantas¹

View full text Add to dashboard Cite

show abstract

“…Risk factors of pulmonary carcinoma include exposure to secondhand smoke and as in other cat cancers increased age but with no higher prevalence among breeds or sex 94 . A recent study has concluded that in areas with high radon exposure, companion animals have a 2-fold higher incidence of primary pulmonary neoplasia 95 . Signs of this cancer include coughing, weight loss, lethargy, lameness, and respiratory changes 31,94 .…”

Section: Pulmonary Carcinomamentioning

confidence: 99%

Characterization of the genetic landscape of feline oral squamous cell carcinoma

Rodney¹

View full text Add to dashboard Cite

Over 94 million domestic cats are susceptible to cancers and other common and rare diseases. While cancer treatment in cats increasingly mirrors that available in humans, treatment failures are more frequent. There are no FDA or USDA approved cancer drugs for cats and a paucity of cancer treatments beyond surgery, radiotherapy, and cytotoxic chemotherapy indicate an urgent need to define the molecular properties of aggressive feline cancers including common cancers such as soft tissue sarcoma, mammary carcinoma, lymphoma, and feline oral squamous cell carcinoma. Whole exome sequencing (WES) is a proven strategy to study these disease-causing variants in humans and other organisms. To examine the effectiveness of WES in the study of feline cancer and Mendelian diseases, whole exome sequencing was conducted on 41 cats with known and unknown genetic diseases and traits, of which ten cats had matching whole genome sequence (WGS) data available, used to validate WES performance. Within the 41 cats, we identified 31 previously known causal variants and discovered new gene candidate variants, including novel missense variance for polycystic kidney disease and atrichia in the Peterbald cat. The WES data was sufficient to identify novel gene candidate alleles for diseases and traits in a feline model. Feline oral squamous cell carcinoma (FOSCC) is a cancer of the squamous cell lining in the oral cavity and represents up to 80 percent of all oral cancers in cats, with a low one-year survival rate of <10 percent. The cancer pathology associated with feline oral squamous cell carcinoma is similar to human head and neck squamous cell carcinoma (HNSCC), which accounts for 90 percent of oral cancers in humans. FOSCC may present as a potential model to study HNSCC due to spontaneous formation, similar genetic landscape, pathology, and survival rates. We have generated single nucleotide variant calls using GATK-Mutect2 on six cats with FOSCC and have fully annotated and identified driver genes in common with HNSCC. Due to low sample size, a larger cohort is needed to draw stronger association of disease-causing traits. Our results show some overlap in the genetic landscape of both cancers, with five samples have mutations in p53, a common mutation in HNSCC, and two samples having four genes in common with HNSCC each. Several samples with mutations in p53 and mutations in genes implicated in HNSCC suggests that the domestic cat could be a viable model for HNSCC.

show abstract

Ecological level analysis of primary lung tumors in dogs and cats and environmental radon activity

Cited by 9 publications

References 21 publications

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

>b<Estudo comparativo de neoplasias pulmonares primárias em cães e humanos>/b<

Characterization of the genetic landscape of feline oral squamous cell carcinoma

Contact Info

Product

Resources

About