Ecological risk assessment of the presence of pharmaceutical residues in a French national water survey

Bouissou-Schurtz, Camille; Houeto, P.; Guerbet, Michel; Bachelot, Morgane; Casellas, Claude; Mauclaire, Anne-Cécile; Panetier, Pascale; Delval, Cécile; Masset, Dominique

doi:10.1016/j.yrtph.2014.04.006

Cited by 122 publications

(49 citation statements)

References 50 publications

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“…The derivation of PECs is typically based on data for pharmaceutical usage, degree of metabolism in humans, removal in wastewater treatment plants (WWTP), and environmental dilution. The method most commonly used is based on the approach recommended in the European Medicines Agency (EMEA) guidelines for assessment of the risk of human pharmaceuticals in the environment [6,9,[17][18][19][20][21][22][23]. Default parameters (e.g., for dilution of wastewater by the receiving water) proposed by the EMEA guidance are regularly used in these prioritization exercises, regardless of their suitability [6,10,18,20].…”

Section: Introductionmentioning

confidence: 99%

Are exposure predictions, used for the prioritization of pharmaceuticals in the environment, fit for purpose?

Burns

Thomas‐Oates

Kolpin

et al. 2017

Enviro Toxic and Chemistry

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Prioritisation methodologies are often used for identifying those pharmaceuticals 22 that pose the greatest risk to the natural environment and to focus laboratory testing or 23 environmental monitoring towards pharmaceuticals of greatest concern. Risk-based 24 prioritisation approaches, employing models to derive exposure concentrations, are 25 commonly used but the reliability of these models is unclear. The present study evaluated 26 the accuracy of exposure models commonly used for pharmaceutical prioritisation. produced similar results in the River Foss. Overall, these findings indicate that PECs may well 37 be appropriate for prioritisation of pharmaceuticals in the environment when robust and 38 local data on the system of interest are available and reflective of most source inputs to the 39 system. 40

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Section: Introductionmentioning

confidence: 99%

Are exposure predictions, used for the prioritization of pharmaceuticals in the environment, fit for purpose?

Burns

Thomas‐Oates

Kolpin

et al. 2017

Enviro Toxic and Chemistry

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“…Over more than two decades, pharmaceuticals and hormones have become crucial micropollutants due to their presence at trace concentrations (generally ng/L range) in the aquatic environment [1][2][3][4][5]. The primary source is prescribed and normal patient use and excretion combined with incomplete removal in wastewater treatment plants (WWTP), which accounts for the predominant portion of detected concentrations.…”

Section: Introductionmentioning

confidence: 99%

Rapid analysis of diclofenac in freshwater and wastewater by a monoclonal antibody-based highly sensitive ELISA

et al. 2015

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The non-steroidal anti-inflammatory drug (NSAID) diclofenac (DCF) is found worldwide in the aqueous environment. Therefore, it has raised increased public concern on potential long-term impact on human health and wildlife. The importance of DCF has been emphasized by the European Union recently by including this pharmaceutical in the first watch list of priority hazardous substances in order to gather Union-wide monitoring data. Rapid and cheap methods of analysis are therefore required for fresh and wastewater monitoring with high sample load. Here, for the first time, well-characterized monoclonal antibodies (mAbs) against DCF were generated and a highly sensitive ELISA developed. The best antibody (mAb 12G5) is highly affine (KD = 1.5 × 10(-10) M), stable to potential matrix interferences such as pH value (pH range 5.2-9.2), calcium ion concentration (up to 75 mg/L), and humic acid content (up to 20 mg/L). The limit of detection (LOD, S/N = 3) and IC50 of the ELISA calibration curve were 7.8 and 44 ng/L, respectively. The working range was defined between 11 and 180 ng/L. On average, about 10 % cross-reactivity (CR) was found for DCF metabolites 5-OH-DCF, 4'-OH-DCF, and DCF-acyl glucuronide, but other structurally related NSAIDs showed binding <1 % compared to the parent compound. While DCF concentrations at the low ppt range were measured in river and lake water, higher values of 2.9 and 2.1 μg/L were found in wastewater influents and effluents, respectively. These results could be confirmed by solid phase extraction combined with LC-MS.

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“…Because the estimated MEC/PNEC (real risk) ratio for ibuprofen was over 1, a probable environmental risk was suggested (Bouissou-Schurtz et al 2014). The hitherto toxic effects of ibuprofen on Scenedesmus subspicatus , Pseudokirchneriella subcapitata , Daphnia magna , Daphnia longispina , Neocaridina denticulata , Danio rerio , Pimephales notatus , Oncorhynchus mykiss , Rutilus rutilus , Oreochromis niloticus , Oryzias latipes , Menidia beryllina and Mytilus galloprovinciali as model organisms were evaluated (Brozinski et al 2013; Fent et al 2006; Flippin et al 2007; Gonzalez-Naranjo and Boltes 2014; Gonzales-Rey and Bebianno 2012; Jeffries et al 2015; Ragugnetti et al 2011; Sung et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

Marchlewicz

Guzik

Hupert-Kocurek

et al. 2017

Environ Sci Pollut Res

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In recent years, the increased intake of ibuprofen has resulted in the presence of the drug in the environment. This work presents results of a study on degradation of ibuprofen at 25 mg L−1 in the presence of glucose, as an additional carbon source by Bacillus thuringiensis B1(2015b). In the cometabolic system, the maximum specific growth rate of the bacterial strain was 0.07 ± 0.01 mg mL−1 h−1 and K sμ 0.27 ± 0.15 mg L−1. The maximum specific ibuprofen removal rate and the value of the half-saturation constant were q max = 0.24 ± 0.02 mg mL−1 h−1 and K s = 2.12 ± 0.56 mg L−1, respectively. It has been suggested that monooxygenase and catechol 1,2-dioxygenase are involved in ibuprofen degradation by B. thuringiensis B1(2015b). Toxicity studies showed that B. thuringiensis B1(2015b) is more resistant to ibuprofen than other tested organisms. The EC50 of ibuprofen on the B1 strain is 809.3 mg L−1, and it is 1.5 times higher than the value of the microbial toxic concentration (MTCavg). The obtained results indicate that B. thuringiensis B1(2015b) could be a useful tool in biodegradation/bioremediation processes.

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Ecological risk assessment of the presence of pharmaceutical residues in a French national water survey

Cited by 122 publications

References 50 publications

Are exposure predictions, used for the prioritization of pharmaceuticals in the environment, fit for purpose?

Are exposure predictions, used for the prioritization of pharmaceuticals in the environment, fit for purpose?

Rapid analysis of diclofenac in freshwater and wastewater by a monoclonal antibody-based highly sensitive ELISA

Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b)

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