Ecological study of Paracoccidioides brasiliensis in soil: growth ability, conidia production and molecular detection

Terçarioli, Gisela Ramos; Bagagli, Eduardo; Reis, Gabriela Martins; Theodoro, Raquel Cordeiro; Bosco, Sandra de Moraes Gimenes; Macoris, Severino Assis Da Graça; Richini-Pereira, Virgínia Bodelão

doi:10.1186/1471-2180-7-92

Cited by 52 publications

(38 citation statements)

References 26 publications

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“…The isolates T10 and Bt84, representing the PS2 species, seemed to have elongated yeast cells and presented a slower M-L transition than the other isolates. In addition to these data, Terçarioli et al [70], studying the fungal growth on Soil Extract Agar, observed that most isolates, except T10 and Bt84, were able to produce, on a large scale, arthoconidia in this medium. Could these differential characteristics be an indication that these two sympatric species may have also occupied different niches in nature?…”

Section: Emergence Of New Variants Of the Pathogenmentioning

confidence: 87%

“…It is interesting to note that the pathogen could be detected mainly in soil samples collected in the interior of the armadillo burrows [70]. We have adapted this same molecular protocol looking for fungal infection in several other wild mammals accidentally killed on roads [71].…”

Section: Origin and Maintenance Of P Brasiliensis' Virulencementioning

confidence: 99%

“…We have studied P. brasiliensis mycelial growth in soils in order to understand how the pathogen interacts with some abiotic factors, such as soil texture and water amount [70]. It was observed that P. brasiliensis grows well in both soil textures (clayey and sandy) when the humidity is high (water saturated), presents moderate growth in soil containing medium humidity, and no growth in lowhumidity soil.…”

Section: Origin and Maintenance Of P Brasiliensis' Virulencementioning

confidence: 99%

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Paracoccidioides brasiliensis: phylogenetic and ecological aspects

et al. 2008

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The knowledge on the biological aspects of Paracoccidioides brasiliensis has evolved greatly since the first description of the disease in 1908. From the pioneers, who were able to clearly demonstrate the fungal nature of the agent, to the recent genomic era, important advances have been achieved. P. brasiliensis is a true fungus, belonging to the Ascomycetous Division, although its sexual phase has not been demonstrated morphologically. A better understanding of the fundamental aspects of the agent, especially its phylogeny and evolutionary history, will provide us with valuable insights allowing a better comprehension of the disease and our capacity to deal with the problem. Concerning the fungus's ecology, although some progress had been observed, the ecological niche of the pathogen has not been determined yet. The aim of the present review is to focus on the biological aspects of P. brasiliensis from an evolutionary point of view, addressing the fungus's phylogenetic aspects, in those special points that might be relevant for the pathogen/ host interactions, the biological forces that have been acting on its origin and maintenance of virulence, as well as in determining the fungus's ecology and epidemiology.

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Section: Emergence Of New Variants Of the Pathogenmentioning

confidence: 87%

Section: Origin and Maintenance Of P Brasiliensis' Virulencementioning

confidence: 99%

Section: Origin and Maintenance Of P Brasiliensis' Virulencementioning

confidence: 99%

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Paracoccidioides brasiliensis: phylogenetic and ecological aspects

et al. 2008

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“…The infection occurs by inhalation of fungus propagules while working with the soil, the probable habitat of P. brasiliensis (Negroni 1966, Albornoz 1971, Restrepo, 1985, Silva-Vergara et al 1998, Terçarioli et al 2007.…”

Section: Introductionmentioning

confidence: 99%

Paracoccidioides brasiliensis infection in dogs from Western Brazilian Amazon

et al. 2012

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The objective of the study was to evaluate Paracoccidioides brasiliensis infection in urban dogs from the municipality of Monte Negro, Rondonia, Western Brazilian Amazon. The serum samples (n=126) were analyzed by indirect ELISA and the immunodiffusion test using P. brasiliensis gp43 and exoantigen as antigens, respectively. A positivity of 54.8% was observed only in the ELISA test and no statistical difference was observed in the seroprevalence in relation to age or sex. This is the ϐirst paracoccidioidomycosis survey carried out with dogs from the Western Brazilian Amazon. The higher positivity rates of P. brasiliensis infection observed in this study suggest that veterinarians must be alert to detect new cases of natural disease in dogs living in paracoccidioidomycosis endemic areas.INDEX TERMS: Paracoccidioides brasiliensis, paracoccidioidomycosis, epidemiology, Amazon, dogs.RESUMO.-[Infecção por Paracoccidioides brasiliensis em cães da Amazônia Ocidental Brasileira.] O objetivo deste estudo foi avaliar a infecção por Paracoccidioides brasiliensis em cães urbanos do município de Monte Negro, Rondônia, Amazônia Ocidental Brasileira. As amostras de soro (n=126) foram analisadas por meio dos testes de ELISA indireto e imunodifusão utilizando gp43 de P. brasiliensis e exoantígeno como antígenos, respectivamente. Uma positividade de 54,8% foi observada apé isso mesmoenas no teste de ELISA e nenhuma diferença estatística foi observada na soroprevalência em relação ao sexo ou à idade. Este é o primeiro estudo epidemiológico de paracoccidioidomicose realizado com cães da Amazônia Ocidental Brasileira. A alta positividade de infecção por P. brasiliensis observada neste estudo sugere que os veterinários devem estar atentos para detectar a doença natural em cães de áreas endêmicas para paracoccidioidomicose.

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“…A sua forma leveduriforme tem sido isolada facilmente em pacientes, tatus e cães infectados (Costa et al 1995a, Costa et al 1995b, Ono et al 2001, Restrepo et al 2001, Bagali et al 2006, Bagali et al 2008. Este fungo também tem sido isolado, esporadicamente, de solo e materiais relacionados, tais como rações de cachorros e fezes de pinguins e morcegos (Franco et al 2000, Tercarioli et al 2007). Apesar de não se conhecer muito bem os aspectos ecológicos deste fungo, existem várias evidências que apontam o solo como o principal habitat saprofítico, como descrito para outras espécies termodimórficas relacionadas: Blastomyces dermatitidis (Baugardner et al 1999), Coccidioides immitis (Kirkland et al 1996), e Histoplasma capsulatum (Zeidberg et al 1952).…”

Section: Fisiopatologia (História Natural Da Pcm)unclassified

Caracterização das bases moleculares da resposta imune inata do hospedeiro murino à paracoccidiomicose

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Ecological study of Paracoccidioides brasiliensis in soil: growth ability, conidia production and molecular detection

Cited by 52 publications

References 26 publications

Paracoccidioides brasiliensis: phylogenetic and ecological aspects

Paracoccidioides brasiliensis: phylogenetic and ecological aspects

Paracoccidioides brasiliensis infection in dogs from Western Brazilian Amazon

Caracterização das bases moleculares da resposta imune inata do hospedeiro murino à paracoccidiomicose

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