Écologie et mode de transmission de Mycobacterium ulcerans

Marsollier, Laurent; Aubry, Jacques; Saint‐André, Jean‐Paul; Robert, Raymond; Legras, Pierre; Manceau, Anne-Lise; Bourdon, Sandra; Audrain, Christine; Carbonnelle, B

doi:10.1016/s0369-8114(03)00151-2

Cited by 42 publications

(35 citation statements)

References 19 publications

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“…Because BU has been associated with aquatic ecosystems and human activities near water bodies (Portaels, 1989;Marsollier et al, 2003;Merritt et al, 2005), it was unexpected that the percent water land cover in a buffer around villages and the distance of a village to the nearest river were not important predictors of the probability of BU presence. Previous studies that have found associations between water and BU, however, were performed over smaller spatial scales.…”

Section: Land Use/land Cover Associated With Buruli Ulcermentioning

confidence: 99%

“…Unlike other mycobacterial infections such as tuberculosis and leprosy, BU transmission is poorly understood but is reported to be associated with disturbed aquatic habitats (Barker, 1973;Barker and Carswell, 1973;Portaels, 1989;Johnson et al, 1999;WHO, 2000a; for more on the epidemiology and clinical features of this disease, see Portaels et al, 1999;Marsollier et al, 2003;Johnson et al, 2005a). Further, although there has been some research targeted at identifying environmental reservoirs and potential vectors, these aspects of the disease still remain speculative, with most reservoirs identified using PCR .…”

Section: Introductionmentioning

confidence: 99%

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A Landscape-based Model for Predicting Mycobacterium ulcerans Infection (Buruli Ulcer Disease) Presence in Benin, West Africa

et al. 2008

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Mycobacterium ulcerans infection (Buruli ulcer [BU] disease) is an emerging tropical disease that causes severe morbidity in many communities, especially those in close proximity to aquatic environments. Research and control efforts are severely hampered by the paucity of data regarding the ecology of this disease; for example, the vectors and modes of transmission remain unknown. It is hypothesized that BU presence is associated with altered landscapes that perturb aquatic ecosystems; however, this has yet to be quantified over large spatial scales. We quantified relationships between land use/land cover (LULC) characteristics surrounding individual villages and BU presence in Benin, West Africa. We also examined the effects of other village-level characteristics which we hypothesized to affect BU presence, such as village distance to the nearest river. We found that as the percent urban land use in a 50-km buffer surrounding a village increased, the probability of BU presence decreased. Conversely, as the percent agricultural land use in a 20-km buffer surrounding a village increased, the probability of BU presence increased. Landscape-based models had predictive ability when predicting BU presence using validation data sets from Benin and Ghana, West Africa. Our analyses suggest that relatively small amounts of urbanization are associated with a decrease in the probability of BU presence, and we hypothesize that this is due to the increased availability of pumped water in urban environments. Our models provide an initial approach to predicting the probability of BU presence over large spatial scales in Benin and Ghana, using readily available land use data.

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Section: Land Use/land Cover Associated With Buruli Ulcermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Landscape-based Model for Predicting Mycobacterium ulcerans Infection (Buruli Ulcer Disease) Presence in Benin, West Africa

et al. 2008

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“…When more discriminatory methods based on detection of variable number tandem repeats were used, many IS2404-positive environmental samples were reported to lack M. ulcerans (18). In light of these recent fi ndings, the relative frequency or abundance of M. ulcerans among aquatic invertebrates or other environmental reservoirs, remains tenuous, and thus, the role of aquatic insect vectors is uncertain.A series of laboratory experiments provided initial evidence for biting hemipteran vectors of M. ulcerans (19)(20)(21)(22)(23). Marsollier et al (9,24) demonstrated that a South American isolate of M. ulcerans could survive and multiply within the salivary glands of aquatic bugs indigenous to France (Naucoridae: Naucoris cimicoides).…”

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confidence: 99%

“…A series of laboratory experiments provided initial evidence for biting hemipteran vectors of M. ulcerans (19)(20)(21)(22)(23). Marsollier et al (9,24) demonstrated that a South American isolate of M. ulcerans could survive and multiply within the salivary glands of aquatic bugs indigenous to France (Naucoridae: Naucoris cimicoides).…”

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confidence: 99%

Aquatic Invertebrates as Unlikely Vectors of Buruli Ulcer Disease

Benbow

Williamson

Kimbirauskas

et al. 2008

Emerg. Infect. Dis.

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Buruli ulcer is a necrotizing skin disease caused by Mycobacterium ulcerans and associated with exposure to aquatic habitats. To assess possible transmission of M. ulcerans by aquatic biting insects, we conducted a fi eld examination of biting water bugs (Hemiptera: Naucoridae, Belostomatidae, Nepidae) in 15 disease-endemic and 12 non-disease-endemic areas of Ghana, Africa. From collections of 22,832 invertebrates, we compared composition, abundance, and associated M. ulcerans positivity among sites. Biting hemipterans were rare and represented a small percentage (usually <2%) of invertebrate communities. No signifi cant differences were found in hemipteran abundance or pathogen positivity between disease-endemic and nondisease-endemic sites, and between abundance of biting hemipterans and M. ulcerans positivity. Therefore, although infection through insect bites is possible, little fi eld evidence supports the assumption that biting hemipterans are primary vectors of M. ulcerans. M ycobacterium ulcerans infection is an emerging skin disease often called Buruli ulcer (BU). Infection results in illness and lasting negative socioeconomic effects in rural areas of the tropics and subtropics (1). The pathologic changes, clinical signs and symptoms, and treatment have been reviewed elsewhere (2-5). In this article we evaluate fi eld evidence for the potential of aquatic invertebrates to be vectors of M. ulcerans.The exact mode of BU transmission remains unknown; however, past epidemiologic studies have associated BU with human activity near, or within, slow-fl owing or standing water bodies that have been created or disturbed by humans (2-4). Although several water-related risk factors have been recognized, none has been consistently reported, making it diffi cult to identify specifi c water-related risk activities (6-8). Most studies suggest that infection occurs through inoculation of M. ulcerans into skin lesions or insect bites (2,4,9-11). Portaels et al. (11) were the fi rst to propose that aquatic insects might serve as vectors of M. ulcerans. This hypothesis maintains that M. ulcerans is found in biofi lms of aquatic habitats and concentrated by grazing or fi lter-feeding invertebrates that are then consumed by predators known to bite humans (11). Initial evidence for this hypothesis used PCR detection of the insertion sequence IS2404 to document M. ulcerans' association with biting water bugs (Hemiptera), fi ltered concentrates of water, detritus, and aquatic plants (4,(12)(13)(14). These studies were important for understanding the possible environmental reservoirs of M. ulcerans. However, IS2404 is now understood to be not specifi c for M. ulcerans because this insertion sequence has been found in a number of other aquatic mycobacterial species, including M. marinum (15)(16)(17). When more discriminatory methods based on detection of variable number tandem repeats were used, many IS2404-positive environmental samples were reported to lack M. ulcerans (18). In light of these recent fi ndings, the relative fr...

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“…Depuis lors, l'incidence de la maladie a augmenté dans ce pays avec 2000 nouveau cas chaque année (Fener, 2009). Bien que la localisation dans les écosystèmes et le mode de transmission ne soient pas encore bien caractérisée, l'épidémiologie de cette infection semble liée aux conditions environnementales et ses modifications (Marsollier et al, 2003). En dépit de ces incertitudes sur le lien environnement-santé, plusieurs études ont souligné l'existence d'un lien environnementale caractérisé par la présence des fleuves, lacs artificiels ou naturels, rivières à débit lent, mares et zones marécageuses, systèmes d'irrigation, zones agricole à proximité de l'eau Brou et al, 2006).…”

Section: Introductionunclassified