Écologie microbienne et sensibilité aux antibiotiques des bactéries isolées d’infections urinaires chez l’enfant au Maroc

Zahir, Hanane; Draïss, Ghizlane; Rada, Noureddine; Abourrahouat, Aicha; Sab, Imane Ait; Sbihi, M.; Bouskraoui, M.; Soraa, Nabila

doi:10.1016/s1773-035x(19)30229-1

Cited by 10 publications

(9 citation statements)

References 19 publications

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“…These samples were taken in outpatient clinics. This rate being similar, compared to other national works that shared percentages ranging from 13.3% to 23% [24,25]. It has been reported that community-acquired urinary tract infections are the most frequent in relation to hospital-acquired infections [26,27].…”

Section: Discussionsupporting

confidence: 84%

Antibiotic resistance in uropathogenic enterobacteria

et al. 2021

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Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.

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Section: Discussionsupporting

confidence: 84%

Antibiotic resistance in uropathogenic enterobacteria

et al. 2021

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“…The study of the sensitivity of isolated strains showed a high resistant to penicillins, Amoxicillin/clavulanic acid and amoxicillin. This result is similar to that of Zahir et al, [29] Imipenem (2.00%) showed very low resistance compared to ertapenem (36.07%) of the carbapenem class. In the aminoglycoside family, gentamicin showed a resistance of 33.74%, lower than the resistance level of ciprofloxacin (52.05%) in the quinolone family.…”

Section: Discussionsupporting

confidence: 91%

Modeling the antimicrobial resistance of enterobacteria responsible for Urinary Tract Infections in Benin: Another way to control Antimicrobial Resistance

Dougnon

Assogba

Mohammed

et al. 2020

Preprint

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Background: Infectious diseases are serious public health issue both in developing countries and industrialized nations. In developing countries, they are the main cause of high mortality rates. In the second group, existing resistance strains to antibiotics is developing and growing at an alarming rate. The purpose of this study was to produce data of national interest to implement sustainable control program against the spread of antimicrobial resistance strains in Benin. Methods: One hundred and ninety (190) urine samples were collected in selected hospitals in Benin from patients with urinary tract infection. After getting the informed consent from the patients, samples collections were performed under aseptic conditions and cultured for further analysis in the laboratory. The resistance profile of the bacterial strains was established. The search for beta-lactamase production by the isolates was performed using the synergy test for amoxicillin/clavulanic acid and cephalosporins. Mathematical modeling for predicting the development of resistance of the strains by the year 2024 was carried out employing the compartmental deterministic models. Results: Two hundred and thirty (230) strains were identified from the urine samples. Male individuals were the most affected by urinary tract infections. Individuals between the ages of 21-30 were predominantly infected. E. coli was the most isolated species (32.43%) in the urine samples, followed by K. pneumoniae (26.85%) and E. cloacae (25.92%). The susceptibility testing of isolates showed a high resistance to amoxicillin (91.82%). Whereas the lowest resistance was to imipenem (2%). The beta-lactamase was produced by 24.03% of the strains. Escherichia coli (32.43%) was the most productive of broad spectrum beta-lactamase, followed by K. pneumoniae (31.03%). The mathematical modeling revealed a rampant rise in resistance development of the strains to the tested antibiotics. Conclusions: These results provide important data for developing new preventive strategies against the evolution of bacterial resistance to antibiotics. It therefore, further deserves a constructive advocacy so that more actions are taken against the rampant spread of antimicrobial resistance strains in our health facilities as well as in the communities.

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“…The study of the sensitivity of isolated strains to enterobacteria shows that they are highly resistant to penicillins including Amoxicillin + clavulanic acid and amoxicillin. This result is similar to that of [29] in his study on the evolution of the resistance of enterobacteria responsible for human infections at the Douala hospital. The different bacterial species isolated showed varying levels of resistance to the different antibiotics used.…”

Section: Discussionsupporting

confidence: 89%

Modeling the antimicrobial resistance of enterobacteria responsible for Urinary Tract Infections in Benin: another way to Control or survey Antimicrobial Resistance

Dougnon

Assogba

GNIMATIN

et al. 2019

Preprint

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Background: Infectious diseases are serious public health issue both in developing countries and industrialized countries. In developing countries, they are the main cause of high mortality rates. In the second group, existing resistance to antibiotics is developing growing at an alarming rate. The purpose of this study was to produce data of national interest to implement sustainable control of antimicrobial resistance as well as it spreads. Methods: One hundred ninety (190) urine samples were collected in several hospitals in Benin from patients suspected of having a urinary tract infection. After getting the inform consent from patients, samples collections were performed under aseptic conditions and were further subjected to bacteriological tests in the laboratory. The resistance profile of the bacterial strains identified was then established. The search for betalactamase production was performed by the synergy test between amoxicillin + clavulanic acid and cephalosporins. Mathematical modeling of the resistance of the strains identified by 2024 was finally carried out using compartmental deterministic models. Results: Two hundred thirty (230) strains were identified from urine samples. Male individuals were the most affected by urinary tract infections. Individuals in the 21-30 age groups were predominant. Escherichia coli was the most isolated bacterial species (32.43%) in this study followed by Klebsiella pneumoniae (26.85%) and Enterobacter cloaceae (25.92%). The susceptibility testing of isolates bacteria to antibiotics showed a strong resistance of strains to amoxicillin (91.82%). The lowest resistance obtained was observed with imipenem (2%). The betalactamase was produced by 24.03% of the strains identified. Escherichia coli (32.43%) was indeed the most productive of betalactamase followed by Klebsiella pneumoniae (31.03%). Mathematical modeling revealed a rampant rise in the resistance of bacteria to the antibiotics tested. Conclusions: These results provide important data for public health. They deserve constructive advocacy so that more specific actions are taken in relation to antimicrobial resistance.

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Écologie microbienne et sensibilité aux antibiotiques des bactéries isolées d’infections urinaires chez l’enfant au Maroc

Cited by 10 publications

References 19 publications

Antibiotic resistance in uropathogenic enterobacteria

Antibiotic resistance in uropathogenic enterobacteria

Modeling the antimicrobial resistance of enterobacteria responsible for Urinary Tract Infections in Benin: Another way to control Antimicrobial Resistance

Modeling the antimicrobial resistance of enterobacteria responsible for Urinary Tract Infections in Benin: another way to Control or survey Antimicrobial Resistance

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