2011
DOI: 10.1128/aac.00013-11
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Ecology and Evolution as Targets: the Need for Novel Eco-Evo Drugs and Strategies To Fight Antibiotic Resistance

Abstract: In recent years, the explosive spread of antibiotic resistance determinants among pathogenic, commensal, and environmental bacteria has reached a global dimension. Classical measures trying to contain or slow locally the progress of antibiotic resistance in patients on the basis of better antibiotic prescribing policies have clearly become insufficient at the global level. Urgent measures are needed to directly confront the processes influencing antibiotic resistance pollution in the microbiosphere. Recent int… Show more

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Cited by 169 publications
(142 citation statements)
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References 159 publications
(148 reference statements)
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“…An experimental programme to test this theory, based on laboratory methods in experimental evolution and high throughput technology, is burgeoning [16 -21], whereas field experiments are more challenging [22,23] and only just starting. Applications are numerous and range from conservation of declining species to strategies for combating antibiotic resistance [24].…”
Section: The Scopementioning
confidence: 99%
“…An experimental programme to test this theory, based on laboratory methods in experimental evolution and high throughput technology, is burgeoning [16 -21], whereas field experiments are more challenging [22,23] and only just starting. Applications are numerous and range from conservation of declining species to strategies for combating antibiotic resistance [24].…”
Section: The Scopementioning
confidence: 99%
“…It is also important to focus efforts towards the development of a personalized therapy that prevents the emergence of resistance in the different environments where it occurs [35,36].…”
Section: Natural Products the Source Of Chemical Diversitymentioning
confidence: 99%
“…Commonly used antibiotics have narrow therapeutic index and their continuous usage leads to antimicrobial resistance [9]. The novel substitutes especially inorganic nanoparticles have recently attracted attention.…”
Section: Antibacterial Propertymentioning
confidence: 99%