Floodplains across the European loess region transformed from nature‐ to human‐dominated environments during the Holocene. A general framework of this evolution is well established, but it is less clear how differences in timing—observed within and between catchments—can be explained. Although human impact is an important driver, little attention has thus far been paid to the actual human activities involved, their intensities, and spatiotemporal patterns. By adopting an interdisciplinary approach, this study provides insight into the evolution of both environmental (e.g., local floodplain geoecohydrology and regional land cover) and human dynamics (e.g., demography and land use) in the Belgian Gete catchment. Results show that the observed changes in land cover and floodplain geoecology can indeed be attributed to spatiotemporal variations in human impact. Human‐induced vegetation change, driven by population growth and associated agrarian production, resulted in hydrological changes and localized colluviation. Catchment‐scale improvement of hillslope‐channel connectivity initiated alluviation in the valleys and completed the transformation from forested marsh to open floodplain with overbank sedimentation. In turn, this allowed people to settle in the floodplains in the Early Medieval period, laying the foundations for our present‐day landscape.