Ecology of Helicobacter pylori in Peru: infection rates in coastal, high altitude, and jungle communities. The Gastrointestinal Physiology Working Group of the Cayetano Heredia and the Johns Hopkins University.

Ramírez-Ramos, Alberto; Gilman, Robert H.; Spira, William M.; Recavarren, Sixto; Watanabe, José; León-Barúa, Raúl; Rodriguez, Christina; Guevara, Cinthya Cecilia Zelada Ladrón de; Gago, G.; Bonilla, Juan Carlos; Cok, Jaime; Ruiz, Elena; Gómez, Erika; Olivares, Elizabeth; García, Raquel; Klinge, Germán Garrido; Vargas, G German; Astete, Magdalena; Valdivia, Meica; Berendson, R.

doi:10.1136/gut.33.5.604

Cited by 28 publications

(2 citation statements)

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“…Previous studies have reported sex differences in H. pylori infection prevalence in Amazonian communities, though the literature is limited. Ramirez‐Ramos et al (1992) investigated the prevalence of H. pylori infection associated with active gastritis in three geographic regions in Peru. They found that male participants had H. pylori infection rates that were approximately 10% higher than females.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

Tallman,

Miller,

Brandley

et al. 2024

American Journal of Biological Anthropology

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ObjectivesHelicobacter pylori (H. pylori)—a gastric bacteria affecting almost 50% of the global population and leading to ulcers and cancer in severe cases—is a growing health concern among Indigenous populations who report a high burden of reported poor general health and gastrointestinal distress. We test hypothesized associations between H. pylori exposure patterns and environmental, social, and biological conditions among a sample of 212 Indigenous Awajún adults (112 males, 100 females, ages 18–65 years) living in the northern Peruvian Amazon.Materials and MethodsDried blood spots were analyzed for H. pylori‐specific IgG using a recently developed enzyme‐linked immunosorbent assay. Resulting seropositivity rates and antibody concentrations, proxying past exposures to H. pylori were analyzed in relation to relevant environmental (toilet type, floor material, reported water quality), social (household size and education level), and biological (age, sex, BMI, blood pressure, immune and metabolic biomarkers) factors using multivariable regression analyses.ResultsWe found near ubiquitous seropositivity for H. pylori exposure in our sample (99.1% seropositive). In the regression analyses, elevations in H. pylori antibody concentrations were significantly higher among males compared to females (β = 0.36, p = 0.01). No associations were found with any other factors.DiscussionAnthropological research in the study communities suggests that the male bias in elevations of H. pylori antibody concentrations is related to cultural and biological factors. Future research is needed to further unravel these biocultural dynamics and determine whether elevations in H. pylori antibody concentrations have clinical relevance for gastrointestinal health outcomes in this population.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

Tallman,

Miller,

Brandley

et al. 2024

American Journal of Biological Anthropology

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“…China exhibits a clear geographical clustering in the distribution of CAG and GC, with Fujian province standing out as a high-incidence area for this condition in the country (Li et al, 1996 ; Yang, 2006 ). The H. pylori infection is an important risk factor for CAG, affecting approximately half of the world's population, but the prevalence varies in different geographic regions (such as coastal, high altitude, and jungle; 1992 ; Yin et al, 2022 ; Malfertheiner et al, 2023 ). H. pylori infection is highly prevalent in coastal areas of China, such as Hainan and Shenzhen, with a high incidence rate among asymptomatic individuals (Li et al, 2022 ; Chen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The mutual interactions among Helicobacter pylori, chronic gastritis, and the gut microbiota: a population-based study in Jinjiang, Fujian

Li,

Hu,

Huang

et al. 2024

Front. Microbiol.

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ObjectivesHelicobacter pylori (H. pylori) is a type of bacteria that infects the stomach lining, and it is a major cause of chronic gastritis (CG). H. pylori infection can influence the composition of the gastric microbiota. Additionally, alterations in the gut microbiome have been associated with various health conditions, including gastrointestinal disorders. The dysbiosis in gut microbiota of human is associated with the decreased secretion of gastric acid. Chronic atrophic gastritis (CAG) and H. pylori infection are also causes of reduced gastric acid secretion. However, the specific details of how H. pylori infection and CG, especially for CAG, influence the gut microbiome can vary and are still an area of ongoing investigation. The incidence of CAG and infection rate of H. pylori has obvious regional characteristics, and Fujian Province in China is a high incidence area of CAG as well as H. pylori infection. We aimed to characterize the microbial changes and find potential diagnostic markers associated with infection of H. pylori as well as CG of subjects in Jinjiang City, Fujian Province, China.ParticipantsEnrollment involved sequencing the 16S rRNA gene in fecal samples from 176 cases, adhering to stringent inclusion and exclusion criteria. For our study, we included healthy volunteers (Normal), individuals with chronic non-atrophic gastritis (CNAG), and those with CAG from Fujian, China. The aim was to assess gut microbiome dysbiosis based on various histopathological features. QIIME and LEfSe analyses were performed. There were 176 cases, comprising 126 individuals who tested negative for H. pylori and 50 who tested positive defined by C14 urea breath tests and histopathological findings in biopsies obtained through endoscopy. CAG was also staged by applying OLGIM system.ResultsWhen merging the outcomes from 16S rRNA gene sequencing results, there were no notable variations in alpha diversity among the following groups: Normal, CNAG, and CAG; OLGIM I and OLGIM II; and H. pylori positive [Hp (+)] and H. pylori negative [Hp (–)] groups. Beta diversity among different groups show significant separation through the NMDS diagrams. LEfSe analyses confirmed 2, 3, and 6 bacterial species were in abundance in the Normal, CNAG, and CAG groups; 26 and 2 species in the OLGIM I and OLGIM II group; 22 significant phylotypes were identified in Hp (+) and Hp (–) group, 21 and 1, respectively; 9 bacterial species exhibited significant differences between individuals with CG who were Hp (+) and those who were Hp (–).ConclusionThe study uncovered notable distinctions in the characteristics of gut microbiota among the following groups: Normal, CNAG, and CAG; OLGIM I and OLGIM II; and Hp (+) and Hp (–) groups. Through the analysis of H. pylori infection in CNAG and CAG groups, we found the gut microbiota characteristics of different group show significant difference because of H. pylori infection. Several bacterial genera could potentially serve as diagnostic markers for H. pylori infection and the progression of CG.

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Dyspepsia in the Community Is Linked to Smoking and Aspirin Use but Not to Helicobacter pylori Infection

Nandurkar¹,

Talley²,

Xia³

et al. 1998

Arch Intern Med

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Ecology of Helicobacter pylori in Peru: infection rates in coastal, high altitude, and jungle communities. The Gastrointestinal Physiology Working Group of the Cayetano Heredia and the Johns Hopkins University.

Cited by 28 publications

References 2 publications

Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

Helicobacter pylori exposure among the Awajún of the Peruvian Amazon: Prevalence and environmental, social, and biological associations

The mutual interactions among Helicobacter pylori, chronic gastritis, and the gut microbiota: a population-based study in Jinjiang, Fujian

Dyspepsia in the Community Is Linked to Smoking and Aspirin Use but Not to Helicobacter pylori Infection

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