Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in
            <i>Drosophila</i>

Hanson, Mark A.; Grollmus, L.; Lemaître, Bruno

doi:10.1126/science.adg5725

Cited by 47 publications

(32 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, pioneering studies in innate immunity revealed that, although Toll signalling to NF-κB is conserved between insects and mammals, Toll functions as a cytokine receptor in Drosophila, unlike Toll-like receptors, which function as PRRs [80][81][82][83]. Furthermore, recent studies indicate that the antimicrobial peptides regulated by NF-κB in different Drosophila species are subjected to diversification and specialization driven by differences in the ecologies of the flies [84].…”

Section: Discussionmentioning

confidence: 99%

Evolutionary immunology to explore original antiviral strategies

Imler,

Cai,

Meignin

et al. 2024

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Over the past 25 years, the field of evolutionary developmental biology (evo–devo) has used genomics and genetics to gain insight on the developmental mechanisms underlying the evolution of morphological diversity of animals. Evo–devo exploits the key insight that conserved toolkits of development (e.g. Hox genes) are used in animals to produce genetic novelties that provide adaptation to a new environment. Like development, immunity is forged by interactions with the environment, namely the microbial world. Yet, when it comes to the study of immune defence mechanisms in invertebrates, interest primarily focuses on evolutionarily conserved molecules also present in humans. Here, focusing on antiviral immunity, we argue that immune genes not conserved in humans represent an unexplored resource for the discovery of new antiviral strategies. We review recent findings on the cGAS-STING pathway and explain how cyclic dinucleotides produced by cGAS-like receptors may be used to investigate the portfolio of antiviral genes in a broad range of species. This will set the stage for evo–immuno approaches, exploiting the investment in antiviral defences made by metazoans over hundreds of millions of years of evolution. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’.

show abstract

Section: Discussionmentioning

confidence: 99%

Evolutionary immunology to explore original antiviral strategies

Imler,

Cai,

Meignin

et al. 2024

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

show abstract

“…However, there is also substantial variation in susceptibility just among species with the "S" allele, suggesting this Diptericin allele is not the sole driver of the patterns observed here. Further study across a broader range of species that vary in their Diptericin alleles are required, perhaps combined with measurements of the speed of induction of Diptericin and other AMPs, given rapid induction has been demonstrated to be important for host survival [34,35,49].…”

Section: Discussionmentioning

confidence: 99%

Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae

Sun,

Hanson,

Walsh

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Pathogen host shifts – where a pathogen jumps from one host species to another – are important sources of emerging infectious diseases. Although viral pathogens are a major source of emerging infectious diseases, there is a growing focus on the emergence of novel bacterial infections through host shifts. However, compared to viruses we know relatively little about the factors that determine whether a bacteria can infect a novel host, such as how host phylogenetics constrains variation in pathogen host range. Here, we experimentally examined susceptibility to bacterial infections using a panel of 36 Drosophilidae species and four bacterial pathogens (Providencia rettgeri, Pseudomonas entomophila, Enterococcus faecalis, Staphylococcus aureus). The outcomes of infection differed greatly among pathogens and across host species. The host phylogeny explains a considerable amount of variation in susceptibility, with the greatest phylogenetic signal for P. rettgeri infection, with 94% of variation in mortality being explained by the host phylogeny. Positive correlations were observed between mortality and bacterial load for three out of the four pathogens. Correlations in susceptibility between the four pathogens were positive but largely non-significant, suggesting susceptibility is mostly pathogen-specific. These results suggest that susceptibility to bacterial pathogens may be predicted by the host phylogeny, but the effect may vary in magnitude between different bacteria.

show abstract

“…Similarly, the compartmentalization of immunerelated genes and fine-tuning of AMP expression in the different parts of the gut of the oriental fruit fly Bactrocera dorsalis results in the separation of diverse niches that favour the cultivation of beneficial microbes [15]. Additionally, it was demonstrated in Drosophila that gene duplication and sequence convergence of the AMPs Diptericins could evolve diverse functions, resulting in a species-specific AMP repertoire needed for adaptation to the occupied ecological niche and its associated microbial community [16,17].…”

Section: Introductionmentioning

confidence: 99%

Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response

Galambos,

Vincent-Monegat,

Vallier

et al. 2024

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Interactions between animals and microbes are ubiquitous in nature and strongly impact animal physiology. These interactions are shaped by the host immune system, which responds to infections and contributes to tailor the associations with beneficial microorganisms. In many insects, beneficial symbiotic associations not only include gut commensals, but also intracellular bacteria, or endosymbionts. Endosymbionts are housed within specialized host cells, the bacteriocytes, and are transmitted vertically across host generations. Host–endosymbiont co-evolution shapes the endosymbiont genome and host immune system, which not only fights against microbial intruders, but also ensures the preservation of endosymbionts and the control of their load and location. The cereal weevil Sitophilus spp. is a remarkable model in which to study the evolutionary adaptation of the immune system to endosymbiosis owing to its binary association with a unique, relatively recently acquired nutritional endosymbiont, Sodalis pierantonius . This Gram-negative bacterium has not experienced the genome size shrinkage observed in long-term endosymbioses and has retained immunogenicity. We focus here on the sixteen antimicrobial peptides (AMPs) identified in the Sitophilus oryzae genome and their expression patterns in different tissues, along host development or upon immune challenges, to address their potential functions in the defensive response and endosymbiosis homeostasis along the insect life cycle. This article is part of the theme issue ‘Sculpting the microbiome: how host factors determine and respond to microbial colonization’.

show abstract

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

Cited by 47 publications

References 80 publications

Evolutionary immunology to explore original antiviral strategies

Evolutionary immunology to explore original antiviral strategies

Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae

Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response

Contact Info

Product

Resources

About