Ecomore 2 project in Cambodia: Integrated vector management for dengue vectors in schools in an entomological/epidemiological approach

Boyer, Sébastien; Fontenille, Didier; Chhuoy, Kalyan; Yean, Sony; Suor, Kimhuor; Chhum, Moeun; Duong, Veasna; Dussart, Philippe; Sorn, Sopheak; Piola, Patrice; Ly, Sowath

doi:10.1016/j.ijid.2020.09.1271

Cited by 3 publications

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“…The copyright holder for this this version posted September 14, 2022. ; https://doi.org/10.1101/2022.09.12.22278870 doi: medRxiv preprint interventions in Southeast Asia, the data are mixed as to how effective these interventions are in reducing disease (38)(39)(40). Community-based interventions should be locally tailored.…”

Section: Discussionmentioning

confidence: 99%

“…This finding, in combination with the findings about living in agricultural settings, strongly suggests that households are important places of exposure to Aedes mosquitoes. While schools are often also the targets of vector control 14 interventions in Southeast Asia, the data are mixed as to how effective these interventions are in reducing disease (38)(39)(40). Community-based interventions should be locally tailored.…”

Section: Discussionmentioning

confidence: 99%

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Determinants of exposure to Aedes mosquitoes: a comprehensive geospatial analysis in peri-urban Cambodia

Parker

Medina

Bohl

et al. 2022

Preprint

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Aedes mosquitoes are some of the most important and globally expansive vectors of disease. Public health efforts are largely focused on prevention of human-vector contact. A range of entomological indices are used to measure risk of disease, though with conflicting results (i.e. larval or adult abundance does not always predict risk of disease). There is a growing interest in the development and use of biomarkers for exposure to mosquito saliva, including for Aedes spp, as a proxy for disease risk. In this study, we conduct a comprehensive geostatistical analysis of exposure to Aedes mosquito bites among a pediatric cohort in a peri-urban setting endemic to dengue, Zika, and chikungunya viruses. We use demographic, household, and environmental variables (the flooding index (NFI), land type, and proximity to a river) in a Bayesian geostatistical model to predict areas of exposure to Aedes aegypti bites. We found that hotspots of exposure to Ae. aegypti salivary gland extract (SGE) were relatively small (< 500m and sometimes < 250m) and stable across the two-year study period. Age was negatively associated with antibody responses to Ae. aegypti SGE. Those living in agricultural settings had lower antibody responses than those living in urban settings, whereas those living near recent surface water accumulation were more likely to have higher antibody responses. Finally, we incorporated measures of larval and adult density in our geostatistical models and found that they did not show associations with antibody responses to Ae. aegypti SGE after controlling for other covariates in the model. Our results indicate that targeted house- or neighborhood-focused interventions may be appropriate for vector control in this setting. Further, demographic and environmental factors more capably predicted exposure to Ae. aegypti mosquitoes than commonly used entomological indices.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Determinants of exposure to Aedes mosquitoes: a comprehensive geospatial analysis in peri-urban Cambodia

Parker

Medina

Bohl

et al. 2022

Preprint

View full text Add to dashboard Cite

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Determinants of exposure to Aedes mosquitoes: A comprehensive geospatial analysis in peri-urban Cambodia

et al. 2023

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Review of dengue vectors in Cambodia: distribution, bionomics, vector competence, control and insecticide resistance

Doeurk,

Marcombe,

Maquart

et al. 2024

Parasites Vectors

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Background Dengue fever is one of the most prevalent mosquito-borne diseases in Cambodia. Until now, no specific vaccine nor antiviral treatment exists the virus causing Dengue fever. Consequently, its prevention relies only on vector control strategies. However, efficient vector control in turn relies on a good knowledge of the biology of the vector species. Therefore, this study aims to provide the first review of the distribution, ecology, meteorological impacts, trophic behavior, vector competence, vector control and insecticide resistance of dengue vector species in Cambodia. Methods A systematic search of the Google Scholar and PubMed databases was conducted for relevant published articles. Of the 610 published articles originally identified, 70 articles were ultimately selected for inclusion in this review. We also included new data from unpublished research conducted in Cambodia between 2017 and 2023 related to dengue vector bionomics. Results Eleven Aedes (Stegomyia) mosquito species have been recorded in Cambodia, including a new species described in 2024. Four species are associated with dengue virus transmission, among which Aedes aegypti and Ae. albopictus are the main vectors and Ae. malayensis and Ae. scutellaris are considered to be potential vectors. Aedes aegypti and Ae. albopictus are present in all provinces of Cambodia. Aedes albopictus shows a preference for forest, rural and suburban areas, while Ae. aegypti is mostly found in urban and suburban areas. The distribution of these two species is also influenced by meteorological factors, seasonality and the availability of breeding habitats and blood meals. Both species are predominant during the rainy season, and their respective density is impacted by precipitation and temperature. Aedes aegypti is characterized as anthropophilic, while Ae. albopictus exhibits zooanthropophilic behavior, and both species have been observed to be predominantly diurnal. In addition, they were found to be highly resistant to the insecticides used in Cambodia for their control, such as temephos for larvae and deltamethrin and permethrin for adult mosquitoes. Conclusions This review provides extensive and important knowledge on dengue vectors in Cambodia. This knowledge is derived not only from published research articles but also from many recent studies in Cambodia on the bionomics of dengue vector species. The review provides valuable information for use by public health authorities on dengue virus transmission and to develop better vector control strategies in the country. Graphical Abstract

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Ecomore 2 project in Cambodia: Integrated vector management for dengue vectors in schools in an entomological/epidemiological approach

Cited by 3 publications

References 0 publications

Determinants of exposure to Aedes mosquitoes: a comprehensive geospatial analysis in peri-urban Cambodia

Determinants of exposure to Aedes mosquitoes: a comprehensive geospatial analysis in peri-urban Cambodia

Determinants of exposure to Aedes mosquitoes: A comprehensive geospatial analysis in peri-urban Cambodia

Review of dengue vectors in Cambodia: distribution, bionomics, vector competence, control and insecticide resistance

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