Economic and Environmental Assessment of Succinic Acid Production from Sugarcane Bagasse

Shaji, Arun; Shastri, Yogendra; Kumar, Vinod; Ranade, Vivek V.; Hindle, Neil

doi:10.1021/acssuschemeng.1c02483

Cited by 32 publications

(25 citation statements)

References 32 publications

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“…In both mid-and high-TRL scenarios, transportation is not typically a significant driver of environmental impacts, but most of the impacts come from other stages, such as agriculture or bioprocessing. This is consistent with previous findings that pointed out these stages to be major drivers of impacts [53,143]. In the case of biomass production, land-use change plays a significant role to the impacts on water consumption and human toxicity, while the biorefinery stage is a major driver of impacts associated with climate change, freshwater eutrophication, and human toxicity.…”

Section: A Case Study To Highlight Trade-offs and Integration Challen...supporting

confidence: 92%

Advances and opportunities in integrating economic and environmental performance of renewable products

Meramo

Sukumara

Fantke

2022

Biotechnol Biofuels

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There is a growing global need to transition from a fossil-based to a bio-based economy to produce fuels, chemicals, food, and materials. In the specific context of industrial biotechnology, a successful transition toward a sustainable development requires not only steering investment toward a bioeconomy, but also responsibly introducing bio-based products with lower footprints and competitive market prices. A comprehensive sustainability assessment framework applied along various research stages to guide bio-based product development is urgently needed but currently missing. To support holistic approaches to strengthen the global bioeconomy, the present study discusses methodologies and provides perspectives on the successful integration of economic and environmental performance aspects to guide product innovation in biotechnology. Efforts on quantifying the economic and environmental performance of bio-based products are analyzed to highlight recent trends, challenges, and opportunities. We critically analyze methods to integrate Techno-Economic Assessment (TEA) and Life Cycle Assessment (LCA) as example tools that can be used to broaden the scope of assessing biotechnology systems performance. We highlight the lack of social assessment aspects in existing frameworks. Data need for jointly applying TEA and LCA of succinic acid as example commodity chemical are assessed at various Technology readiness levels (TRLs) to illustrate the relevance of the level of integration and show the benefits of the use of combined assessments. The analysis confirms that the implementation of integrated TEA and LCA at lower TRLs will provide more freedom to improve bio-based product’s sustainability performance. Consequently, optimizing the system across TRLs will guide sustainability-driven innovation in new biotechnologies transforming renewable feedstock into valuable bio-based products.

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Section: A Case Study To Highlight Trade-offs and Integration Challen...supporting

confidence: 92%

Advances and opportunities in integrating economic and environmental performance of renewable products

Meramo

Sukumara

Fantke

2022

Biotechnol Biofuels

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“…For the laboratory fed-batch scenario, the MPSP, GWP100, and FEC of our biorefinery were the lowest reported values thus far for a biorefinery producing SA. Furthermore, for the pilot batch scenario, the biorefinery's MPSP of $1.37/kg [$1.23-1.54/kg; 5th-95th percentiles, hereafter in brackets] was consistently below the reported market price range of $2.53-2.89/kg 30 (adjusted to 2016$) and near the low end of bio-based SA MPSP values ranging from $1.08-3.63/kg reported in the literature 42,43,44,45,46,47,48,49,50 (Fig. 4A).…”

Section: Discussionmentioning

confidence: 75%

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

Tran

Mishra

Bhagwat

et al. 2023

Preprint

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As one of the top value-added chemicals, succinic acid has been the focus of numerous metabolic engineering campaigns since the 1990s. However, microbial production of succinic acid at an industrially relevant scale has been hindered by high downstream processing costs arising from neutral pH fermentation. Here we describe the metabolic engineering of Issatchenkia orientalis, a non-conventional yeast with superior tolerance to highly acidic conditions, for cost-effective succinic acid production. Through deletion of byproduct pathways, transport engineering, and expanding the substrate scope, the resulting strains could produce succinic acid at the highest titers in sugar-based media at low pH (pH 3) in fed-batch fermentations using bench-top reactors, i.e. 109.5 g/L in minimal medium and 104.6 g/L in sugarcane juice medium. We further performed batch fermentation in a pilot-scale fermenter with a scaling factor of 300-fold, achieving 63.1 g/L of succinic acid using sugarcane juice medium. A downstream processing comprising of two-stage vacuum distillation and crystallization enabled direct recovery of succinic acid, without further acidification of fermentation broth, with an overall yield of 64.0%. Finally, we simulated an end-to-end low-pH succinic acid production pipeline, and techno-economic analysis and life cycle assessment indicate our process is financially viable and can reduce life cycle greenhouse gas emissions by 34-90% relative to fossil-based production processes. We expect I. orientalis can serve as a general industrial platform for the production of a wide variety of organic acids.

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“…The GHG emissions of succinic acid produced from various sources of raw materials such as bread waste (Gadkari et al, 2021), corn (Cok et al, 2013), sorghum (Moussa et al, 2016), sugarcane bagasse (Shaji et al, 2021), and fossil fuel (Cok et al, 2013) have been compared with that from EFB as shown in Figure 3. Producing bio-based succinic acid emits GHGs ranging from 0.87 to 1.39 kg CO2 eq/kg bio-based succinic acid.…”

Section: Environmental Impact Assessmentmentioning

confidence: 99%

Sustainability assessment of palm oil-based refinery systems for food, fuel, and chemicals

et al. 2022

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Palm-based biorefinery system has gained attention worldwide because of potentially high economic returns. However, environmental impacts also increase with the additional production. Therefore, this study aims to assess the sustainability of (1) current palm-based biorefinery system in Thailand, including cooking oil and biodiesel, and (2) palm-based biorefinery system with value-added products, i.e., succinic acid, lactic acid, bio-hydrogenated diesel (BHD), and epichlorohydrin (ECH) that represent biomaterial, biofuel, and biochemical products, respectively. Accordingly, seven palm-based biorefinery scenarios were designed, and their sustainability was assessed through life cycle assessment (LCA), net energy balance (NEB) and net energy ratio (NER), employment generation, and eco-efficiency. The results revealed that value-added production increased global warming impacts by around 3 – 79% compared with the current system. Although environmental impacts increased due to the additional processes related to the production of the value-added products, total product values also increased, especially for succinic acid, generally leading to higher eco-efficiency values. The current palm-based biorefinery system with succinic acid production had the highest eco-efficiency among all the scenarios considered. The BHD production scenario had the highest NEB and NER because the products were used for energy. Employment generation increased for all the scenarios between 2 – 86% compared with the current system.

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Economic and Environmental Assessment of Succinic Acid Production from Sugarcane Bagasse

Cited by 32 publications

References 32 publications

Advances and opportunities in integrating economic and environmental performance of renewable products

Advances and opportunities in integrating economic and environmental performance of renewable products

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

Sustainability assessment of palm oil-based refinery systems for food, fuel, and chemicals

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