Economic and epidemiological impact of dengue illness over 16 years from a public health system perspective in Brazil to inform future health policies including the adoption of a dengue vaccine

Godói, Isabella Piassi Dias; Silva, Leonardo Vinicius Dias da; Sarker, Abdur Razzaque; Megiddo, Itamar; Morton, Alec; Godman, Brian; Alvarez-Madrazo, Samantha; Bennie, Marion; Guerra, Augusto Afonso

doi:10.1080/14760584.2018.1546581

Cited by 17 publications

(20 citation statements)

References 37 publications

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“…Existing international register studies usually help determine current disease burden with implications for, for example, the funding of new treatments or others-but usually not multiple conditions [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark

Hvidberg

Johnsen

Davidsen

et al. 2019

PharmacoEconomics Open

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Background Real-world data of disease prevalence represents an important but underutilised source of evidence for health economic modelling. Aims The aim of this study was to estimate nationwide prevalence rates and summarise the characteristics of 199 chronic conditions using Danish population-based health registers, to provide an off-the-shelf tool for decision makers and researchers. Methods The study population comprised all Danish residents aged 16 years or above on 1 January 2013 (n = 4,555,439). The study was based on the linkage of national registers covering hospital contacts, contacts with primary care (including general practitioners) and filled-in out-of-hospital prescriptions. Results A total of 65.6% had one or more chronic condition. The ten conditions with the highest degree of prevalence were hypertension (23.3%), respiratory allergy (18.5%), disorders of lipoprotein metabolism (14.3%), depression (10.0%), bronchitis (9.2%), asthma (7.9%), type 2 diabetes (5.3%), chronic obstructive lung disease (4.7%), osteoarthritis of the knee (3.9%) and finally osteoporosis (3.5%) and ulcers (3.5%) in joint tenth place. Characteristics by gender, age and national geographical differences were also presented. Conclusions A nationwide catalogue of the prevalence rates and characteristics of patients with chronic conditions based on a nationwide population is provided. The prevalence rates of the 199 conditions provide important information on the burden of disease for use in healthcare planning, as well as for economic, aetiological and other research.

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Section: Discussionmentioning

confidence: 99%

A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark

Hvidberg

Johnsen

Davidsen

et al. 2019

PharmacoEconomics Open

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“…In Brazil, overall, vector control programs have not produced satisfactory results; hence, the effectiveness of these interventions is still very limited [10][11][12] . Investments in the implementation of a rigorous and continuous national program and effective management of public services such as garbage collection and structured sanitation networks are required to reduce the prevalence of the disease in the country 13,14 . The identification of high-risk areas is necessary for the implementation of directed public health policies and basic services to reduce the burden of dengue 15 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of self-reported dengue infections in Manaus Metropolitan Region: a cross-sectional study

Tiguman

Silva

Souza

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: Dengue is an endemic and epidemic disease in Brazil, with a high burden of disease. Amazonas State has a high risk of transmission. This study aimed to assess the self-reported prevalence of dengue in adults living in Manaus Metropolitan Region. Methods: A cross-sectional study was conducted with adults living in Manaus Metropolitan Region in 2015. We performed a three-phase probabilistic sampling to collect participants' clinical and sociodemographic data. Self-reported dengue infection in the previous year was the primary outcome. Descriptive statistics and Poisson regression analysis with robust variance were used to calculate the prevalence ratio (PR) of dengue infections with 95% confidence intervals (95% CIs). Multilevel analysis including city and neighborhood variables was calculated. All analyses considered the complex sampling. Results: Among the 4,001 participants, dengue in the previous year was self-reported by 7.0% (95% CI 6.3%-7.8%). Dengue was more frequent in women(PR 1.51; 95% CI 1.06-2.13), elderly participants (≥60 years old, PR 2.54; 95% CI 1.19-5.45), White and Asian participants (PR, 1.57; 95% CI, 1.11-2.23), and individuals who had not received endemic agent visits (PR, 2.28; 95% CI, 1.31-3.99). After multilevel analysis, sex was no longer a significant variable, with the remaining associations still significant. Conclusions: Seven out of 100 inhabitants of Manaus Metropolitan Region reported dengue in the previous year. Dengue was predominantly observed in women, elderly individuals, White and Asian individuals, and individuals who did not receive endemic agent visits. The setting plays an important role in dengue infections.

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“…Therefore, further extensive simulations and analyses should be carried out in future work. Furthermore, as the epidemiological and morbidity burden associated with dengue increase substantially, it becomes more critical to measure estimates of health and economic costs of the disease [5,57,58]. Extensive cost-effectiveness analyses based on real dengue burden should be carried out in future research.…”

Section: Discussionmentioning

confidence: 99%

The Role of Vertical Transmission in the Control of Dengue Fever

Murillo

Lee

2019

IJERPH

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In this work, a two-strain dengue model with vertical transmission in the mosquito population is considered. Although vertical transmission is often ignored in models of dengue fever, we show that effective control of an outbreak of dengue can depend on whether or not the vertical transmission is a significant mode of disease transmission. We model the effect of a control strategy aimed at reducing human-mosquito transmissions in an optimal control framework. As the likelihood of vertical transmission increases, outbreaks become more difficult and expensive to control. However, even for low levels of vertical transmission, the additional, uncontrolled, transmission from infected mosquito to eggs may undercut the effectiveness of any control function. This is of particular importance in regions where existing control policies may be effective and the endemic strain does not exhibit vertical transmission. If a novel strain that does exhibit vertical transmission invades, then existing, formerly effective, control policies may no longer be sufficient. Therefore, public health officials should pay more attention to the role of vertical transmission for more effective interventions and policy.

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Economic and epidemiological impact of dengue illness over 16 years from a public health system perspective in Brazil to inform future health policies including the adoption of a dengue vaccine

Cited by 17 publications

References 37 publications

A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark

A Nationwide Study of Prevalence Rates and Characteristics of 199 Chronic Conditions in Denmark

Prevalence of self-reported dengue infections in Manaus Metropolitan Region: a cross-sectional study

The Role of Vertical Transmission in the Control of Dengue Fever

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