Economic assessment of aseptic compounding rooms in hospital pharmacies in five European countries

Dekyndt, B.; Décaudin, Bertrand; Lannoy, Damien; Odou, Pascal

doi:10.1177/1078155214520820

Cited by 8 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few estimations of the cost/effectiveness balance of such devices have so far been made and would prove useful. In a previous study by Dekyndt et al ., they were shown to result in a slight increase in preparation cost, as well as in compounding time [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundThe objective of this randomized, prospective and controlled study was to investigate the ability of a closed-system transfer device (CSTD; BD-Phaseal) to reduce the occupational exposure of two isolators to 10 cytotoxic drugs and compare to standard compounding devices.Methods and FindingsThe 6-month study started with the opening of a new compounding unit. Two isolators were set up with 2 workstations each, one to compound with standard devices (needles and spikes) and the other using the Phaseal system. Drugs were alternatively compounded in each isolator. Sampling involved wiping three surfaces (gloves, window, worktop), before and after a cleaning process. Exposure to ten antineoplastic drugs (cyclophosphamide, ifosfamide, dacarbazine, 5-FU, methotrexate, gemcitabine, cytarabine, irinotecan, doxorubicine and ganciclovir) was assessed on wipes by LC-MS/MS analysis. Contamination rates were compared using a Chi2 test and drug amounts by a Mann-Whitney test. Significance was defined for p<0.05. Overall contamination was lower in the “Phaseal” isolator than in the “Standard” isolator (12.24% vs. 26.39%; p < 0.0001) although it differed according to drug. Indeed, the contamination rates of gemcitabine were 49.3 and 43.4% (NS) for the Standard and Phaseal isolators, respectively, whereas for ganciclovir, they were 54.2 and 2.8% (p<0.0001). Gemcitabine amounts were 220.6 and 283.6 ng for the Standard and Phaseal isolators (NS), and ganciclovir amounts were 179.9 and 2.4 ng (p<0.0001).ConclusionThis study confirms that using a CSTD may significantly decrease the chemical contamination of barrier isolators compared to standard devices for some drugs, although it does not eliminate contamination totally.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The comparison of design and operating costs between controlled atmosphere areas (CAA) with isolators and CAA with laminar flow biological safety cabinets (BSC), in five European countries, revealed that preparation costs in group BSC appears higher than in the isolators group [32]. However, this study includes preparation of cytotoxic drugs, total parenteral nutrition (TPN) and others.…”

Section: Primary Engineering Controlmentioning

confidence: 99%

Oncology pharmacy units: a safety policy for handling hazardous drugs and related waste in low- and middle-income African countries—Angolan experience

Conceição

Bernardo

Lopes

et al. 2015

ecancer

View full text Add to dashboard Cite

In African countries, higher rates of late-stage cancers at the time of first diagnosis are a reality. In this context, hazardous drugs (HDs), such as chemotherapy, play an important role and have immense benefits for patients’ treatment.HDs should be handled under specific conditions. At least a class 5 environment primary engineering control (PEC), physically located in an appropriate buffer area, is mandatory for sterile HDs compounding, as well as administrative control, personal protective equipment, work practices and other engineering and environmental controls, in order to protect the environment, patient, and worker.The aim of this study is to describe the Angolan experience regarding the development of oncology pharmacy units and discuss international evidence-based guidelines on handling HDs and related waste. Measures to incorporate modern and economical solutions to upgrade or build adequate and safe facilities and staff training, in order to comply with international guidelines in this area, are crucial tasks for African countries of low and middle income.

show abstract

“…The automation of preparation seemed an attractive approach, 29 but antineoplastic drug traces were still to be found on the internal parts of robots. 30 Therefore, despite recommended measures that, unfortunately, are not always respected 31,32 and various approaches to reduce occupational exposure, residual contamination to these drugs is still detected.…”

Section: Introductionmentioning

confidence: 99%

“…In Europe, various biodecontamination procedures have been reported to maintain the cleanliness of biosafety cabinets or isolators where intravenous antineoplastic drugs are prepared. 32 The main cleaning agents are 70% ethanol and peracetic acid for biosafety cabinets and 70% ethanol for isolators. Hydrogen peroxide has also been used for the biodecontamination of isolators.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficiency of degradation or desorption methods in antineoplastic drug decontamination: A critical review

Simon

Odou

Décaudin

et al. 2019

J Oncol Pharm Pract

Self Cite

View full text Add to dashboard Cite

Although considerable efforts have been made over the last 40 years, occupational exposure to antineoplastic drugs is still a daily concern, since eradicating such contamination from workplaces seems unattainable. Considerable data are currently available on the risks associated with their use at work. Hospital facilities are often cleaned with marketed antimicrobials whose chemical decontamination efficacy certainly differs but remains unknown. To keep compounding facilities sterile, alcohol-based solutions are frequently used but with very limited efficiency. It would be particularly useful if a decontamination method could be added to the means already available so that all conventional antineoplastic drug contamination could be removed. Several degradation methods or desorption methods have previously been experimented, with varying success. They have never been compared or discussed in terms either of efficiency or usability. This review aims to analyse and discuss the results of each degradation or decontamination procedure and to compare them. This should facilitate selection of the method to be implemented in daily practice.

show abstract

Economic assessment of aseptic compounding rooms in hospital pharmacies in five European countries

Cited by 8 publications

References 6 publications

Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study

Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study

Oncology pharmacy units: a safety policy for handling hazardous drugs and related waste in low- and middle-income African countries—Angolan experience

Efficiency of degradation or desorption methods in antineoplastic drug decontamination: A critical review

Contact Info

Product

Resources

About