Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad

Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo

“…A review of the literature suggests a wide range of cold chain costs, thus for the purpose of our analyses, we assumed the cost in DRC to be $0.57 per dose of vaccine, with an additional $0.02 per dose during an SIA [34,35]. Other countries have estimated cold chain costs to be substantially lower; therefore, our assumption may represent an overestimate.…”

Rational design of heat stable lyophilized rotavirus vaccine formulations

“…Several studies show that thermostability has a positive impact by way of lowering loss of vaccine potency, reducing wastage, improving reach as well as reducing cold-chain and logistics cost. 24-26 Reduction in process losses, particularly for pentavalent, multidose formulations described herein, will minimize cost-impact and favor incorporation of lyophilization for heat stabilization of RVV. Furthermore, a heat stable vaccine with stability profile of HSRV04D and HSRV04D5 will require less antigen overfill to compensate for titer losses incurred during shelf life storage compared to a liquid vaccine.…”

Practice of Controlled Temperature Chain (CTC) Technique during a Mass Vaccination Campaign in Côte d’Ivoire

“…The vaccinators in the present study may not, therefore, have been coached enough to practice CTC effectively in the field. Regarding the obvious economic benefits that CTC practice can provide [10], full advantage was taken during this vaccination campaign insofar as commuting and associated costs for supplying vaccines were concerned. During the campaign, vaccinators noted the positive impact of not having to use cold packs on the weight of vaccine carriers.…”

“…To eradicate meningitis A in the African meningitis belt, this vaccine has been used in mass vaccination campaigns in several countries including Burkina Faso, Chad, Benin, Nigeria and Togo [6]- [8]. From the economic perspective, MenAfriVac TM provides benefits in terms of time and resources required for the maintenance of an adequate cold chain during immunization campaigns [9] [10]. Vaccination teams, as noted during previous vaccination campaigns, have found this new technique to be advantageous [10].…”

“…From the economic perspective, MenAfriVac TM provides benefits in terms of time and resources required for the maintenance of an adequate cold chain during immunization campaigns [9] [10]. Vaccination teams, as noted during previous vaccination campaigns, have found this new technique to be advantageous [10]. Many studies have been conducted on the economic aspects, immunogenicity, and perception of immunization stakeholders in regard to CTC.…”