Economic burden of gastro-oesophageal reflux disease and dyspepsia: A community-based study

Moghimi-Dehkordi, Bijan; Vahedi, Mohsen; Mansoori, Babak Khoshkrood; Kasaeian, Amir; Safaee, Azadeh; Habibi, Mehri; Pourhoseingholi, Asma; Pourhoseingholi, Mohammad Amin; Zali, Mohammad Reza

doi:10.1016/j.ajg.2011.03.005

Cited by 24 publications

(22 citation statements)

References 23 publications

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“…This diversity is the result of difference in definitions, variability in genetics and moreover, diverse environmental factors including nutrition and diet. For example, the prevalence of GERD in Iranian general population is reported from a minimum of 2.8%, 32 to a maximum of 58.5%. 33 Based on the better methodology, in a large cohort study with 50,000 participants in the North of Iran a representative prevalence rate of 20% has been estimated.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

Farjam

Sharafi

Bahramali

et al. 2018

Middle East J Dig Dis

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BACKGROUND Despite progress in the health indexes in recent years, health inequalities remain as a global challenge within and between regions and countries. This study is the first to quantify the socioeconomic inequity in gastroesophageal reflux disease (GERD) using the concentration index. METHODS In this cross-sectional study, we used baseline data (7012 subjects) from the Fasa Cohort Study (the Southern Iran). The principal component analysis was used to construct socioeconomic status of the participants. The concentration index and concentration curve were used to measure socioeconomic-related inequality in GERD. Decomposition of concentration index was also done to identify the contribution of each explanatory variable to the wealth-related inequality in GERD prevalence. RESULTS The prevalence of GERD was 16.9% (95% CI: 15.9-17.7%). The overall concentration index for GERD was 0.093 (95% CI: 0.062-0.166]. Correspondingly, this figure for men and women were 0.116 (95% CI: 0.062-0.171%) and 0.091 (95% CI: 0.044-0.137%), respectively. The main contributors of socioeconomic-related inequality in GERD prevalence were socioeconomic status (64.4%), alcohol drinking (29%), and age (8.4%). CONCLUSION GERD is significantly more concentrated among richest people. There was significant socioeconomic inequality in GERD according to some individual factors. These inequalities need to be addressed by policy makers to identify the vulnerable subgroups and to reduce the disease burden in the community.

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Section: Discussionmentioning

confidence: 99%

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

Farjam

Sharafi

Bahramali

et al. 2018

Middle East J Dig Dis

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“…Patients with these overlapping conditions have lower quality of life3 and higher health care costs than patients who suffer from either GERD or FD 2. Acid suppression medications are usually effective for a subset of dyspeptic patients with typical reflux symptoms including heartburn and acid regurgitation.…”

Section: Discussionmentioning

confidence: 99%

“…Dyspeptic symptoms are commonly observed among patients with gastroesophageal reflux disease (GERD) 1,2. Patients who experience both dyspeptic and GERD symptoms have been reported to have impaired quality of life compared to patients with only dyspeptic or GERD symptoms 1,3.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic and Diagnostic Value of 2-week High Dose Proton Pump Inhibitor Treatment in Overlapping Non-erosive Gastroesophageal Reflux Disease and Functional Dyspepsia Patients

Kriengkirakul¹,

Patcharatrakul²,

Gonlachanvit³

2012

J Neurogastroenterol Motil

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Background/AimsTo evaluate the value of a 2-week high dose proton pump inhibitor (PPI) treatment on patients with overlapping non-erosive gastroesophageal reflux disease (NERD) and functional dyspepsia (FD).MethodsSixty overlapping NERD and FD patients with symptom onset > 3 months prior underwent 24-hour esophageal pH monitoring studies. All patients received rabeprazole 20 mg b.i.d. for 2 weeks. The reflux and dyspeptic symptoms were evaluated using a symptom questionnaire with 4-point Likert scales before and at the end of treatment. A positive PPI test was defined as score improvement in ≥ 50% from the baseline in the typical reflux symptoms.ResultsThe prevalence of each reflux and dyspeptic symptom did not differ significantly between patients with positive and negative pH tests. After the PPI treatment, epigastric burning, acid regurgitation, heartburn, nausea, vomiting and chest discomfort scores were significantly improved compared to pretreatment values (P < 0.05), whereas postprandial abdominal fullness, early satiation, belching and food regurgitation were not. The proportion of patients who responded to the PPI treatment did not differ significantly between patients with positive and negative pH tests. The sensitivity, specificity, PPV, NPV and accuracy of 2-week high dose rabeprazole treatment for diagnosing gastroesophageal reflux disease were 47%, 38%, 50%, 35% and 43%, respectively.ConclusionsThe two-week high dose PPI treatment was not effective for early satiation, postprandial abdominal fullness, regurgitation or belching symptoms in patients with overlapping NERD and FD. Acid exposure in the distal esophagus could not predict the response of symptoms to PPI. In addition, the 2-week PPI test provided limited value for gastroesophageal reflux disease diagnosis in patients with overlapping NERD and FD.

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“…A common disorder, GERD, causes persistent symptoms in 79-87% of patients [15] and poses significant HR-QOL impairment in affected individuals [16]. Upper endoscopy and 24-h pH-impedance tests, both useful diagnostics tools for GERD, are not readily available particularly in the primary care settings.…”

Section: Discussionmentioning

confidence: 99%

Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting

Vadivelu

Feei

Ong

et al. 2018

Dig Dis

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Background: Gastroesophageal Reflux Disease Questionnaire (GERDQ) and Quality of Life in Reflux and Dyspepsia Questionnaire (QOLRAD) are reliable tools for evaluation of GERD. Aim: We aimed to test validity and reliability of Malay language translations of GERDQ and QOLRAD in a primary care setting. Methods: The questionnaires were first translated into the Malay language (GERDQ-M and QOLRAD-M). Patients from primary care clinics with suspected GERD were recruited to complete GERDQ-M, QOLRAD-M, and Malay-translated 36-item short-form health survey (SF-36 or SF-36-M), and underwent endoscopy and 24-h pH-impedance test. Results: A total of 104 (mean age 47.1 years, women 51.9%) participants were enrolled. The sensitivity and specificity for GERDQ-M cut-off score ≥8 were 90.2 and 77.4%, respectively. Based on this cut-off score, 54.7% had a high probability of GERD diagnosis. GERD-M score ≥8 vs. < 8 was associated with erosive esophagitis (p < 0.001), hiatus hernia (p = 0.03), greater DeMeester score (p = 0.001), and Zerbib scores for acid refluxes (p < 0.001) but not non-acid refluxes (p = 0.1). Mean total scores of QOLRAD-M and SF-36-M were correlated (r = 0.74, p < 0.001). GERDQ-M ≥8, erosive esophagitis, and DeMeester ≥14.72 were associated with impaired QOLRAD-M in all domains (all p < 0.02) but this was not seen with SF-36. Conclusions: GERDQ-M and QOLRAD-M are valid and reliable tools applicable in a primary care setting.

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Economic burden of gastro-oesophageal reflux disease and dyspepsia: A community-based study

Cited by 24 publications

References 23 publications

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

The Therapeutic and Diagnostic Value of 2-week High Dose Proton Pump Inhibitor Treatment in Overlapping Non-erosive Gastroesophageal Reflux Disease and Functional Dyspepsia Patients

Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting

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