Economic burden of heart failure: A summary of recent literature

Lee, Won Chan; Chavez, Y.; Baker, Tim; Luce, Bryan R.

doi:10.1016/j.hrtlng.2004.06.008

Cited by 153 publications

(119 citation statements)

References 54 publications

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“…12 (13) 8 (9) Chronic obstructive airways disease, n (%) 8 (9) 8 (9) Diabetes, n (%) 34 (37) 31 (34) Chronic renal failure, n (%) (estimated GFR ,60 mL/min/1.72 m 2 ) 63 ( Home telemonitoring in elderly heart failure population heart failure service. This outcome was achieved at a modest incremental cost.…”

Section: Discussionmentioning

confidence: 99%

“…1 Much effort has been expended to reduce the risk of repeat hospitalization, particularly since this accounts for 60 -70% of the health care expenditure on heart failure. 2 Heart failure disease management programmes can reduce readmission rates and mortality. 3,4 Although the interventions vary, a multi-disciplinary team approach with specialist heart failure nurses playing a pivotal role in monitoring signs and symptoms, optimizing medication, providing education, co-ordinating care, and facilitating self-care is now recommended in international guidelines.…”

Section: Introductionmentioning

confidence: 99%

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A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home‐HF study

Dar

Riley

Chapman

et al. 2009

European J of Heart Fail

128

217

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Aims Heart failure chiefly affects the elderly, with frequent emergency admissions. Telemonitoring can identify worsening heart failure but previous randomized trials have enrolled selected patient populations. The Home‐HF study examined the impact of home telemonitoring on typical heart failure patients discharged from three acute hospitals in North West London, UK. Methods and results Patients hospitalized with heart failure were randomized to telemonitoring or usual specialist care. Primary outcome measures were days alive and out of hospital. Secondary outcome measures were number and duration of heart failure hospitalizations, clinic visits, and quality of life. We recruited 182 patients. There was no difference in the primary outcome measure in the two groups, but there were significantly fewer unplanned hospitalizations for heart failure decompensation, and a reduction in clinic and emergency room visits in the telemonitoring group. There was no statistically significant difference in the mean direct health service costs. Conclusion Home telemonitoring in a typical elderly population of heart failure patients produces a similar outcome to ‘usual’ specialist care, but reduces clinic and emergency room visits and unplanned heart failure rehospitalizations at little additional cost. This method of disease monitoring may allow specialist services to increase the number of patients under their care.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home‐HF study

Dar

Riley

Chapman

et al. 2009

European J of Heart Fail

128

217

View full text Add to dashboard Cite

show abstract

“…This population-based approach, has provided robust answers to most of the questions which stimulated initiation of this project [1][2][3][4][5][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

The prognostic influence of chronic obstructive pulmonary disease in patients hospitalised for chronic heart failure

Macchia¹,

Monte

Romero

et al. 2007

European J of Heart Fail

101

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Aims: To investigate the prevalence and the prognostic impact of chronic obstructive pulmonary disease (COPD), in patients hospitalised with chronic heart failure (CHF). Methods and results:In an observational study based on longitudinal information from administrative registers, 1020 patients aged ≥ 60 years, who were chronically treated for and hospitalised with CHF were identified and followed-up for major events up to 1 year.Median age was 80 years, half of the patients were female and 241 patients (23.6%) had concomitant COPD. There were no differences in the prevalence of cardiovascular and non-cardiovascular comorbidities between CHF patients with or without COPD. However, COPD patients were more often male (60.6% vs. 46.3%), more frequently treated with diuretics (95.9% vs. 91.5%) but less often exposed to β-blockers (16.2% vs. 22.0%). Significantly higher adjusted in-hospital (HR 1.50 [95%CI 1.00-2.26]) and out-of-hospital (1.42 [1.09-1.86]) mortality rates were found in CHF patients with concomitant COPD. A higher occurrence of non-fatal AMI/stroke/rehospitalisation for CHF (1.26 [1.01-1.58]) as well as hospitalisation for CHF (1.35 [1.00-1.82]) was associated with COPD. Conclusions: COPD is a frequent concomitant disease in patients with heart failure and it is an independent short-term prognostic indicator of mortality and cardiovascular comorbidity in patients who have been admitted to hospital for heart failure.

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“…4,5 The identification of noninvasive imaging biomarkers that could be used to ascertain which patients might benefit from induction chemotherapy before initiation of treatment is important because not all patients respond to chemotherapy and the cost and toxic side effects induced by induction chemotherapy cannot be ignored. 6,7 In addition, if we could predict poor treatment response before initiating induction chemotherapy, we could apply alternative therapies or modify therapies early in the course of treatment in individual patients to improve their quality of life and increase survival.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Head and Neck: Comparison of Diffusion-weighted MRI at b-values of 1,000 and 2,000 s/mm<sup>2</sup> to Predict Response to Induction Chemotherapy

Ryoo

Kim

Choi

et al. 2015

MRMS

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Purpose: Recent publications have reported contradictory results of pretreatment diffusion-weighted magnetic resonance imaging (DWI) for the prediction of chemoradiotherapeutic response in primary squamous cell carcinomas of the head and neck (HNSCC). Therefore, we evaluated the diagnostic performance of DWI obtained with both standard (b = 0 and 1,000 s/mm 2 ) and high (b = 0 and 2,000 s/mm 2 ) b-values for predicting response to induction chemotherapy in HNSCCs.Methods: For 25 patients with primary HNSCC who underwent DWI with both standard and high b-values prior to treatment, we calculated corresponding apparent diffusion coefficient (ADC) maps. Regions of interest containing the tumor were drawn on every section of ADC maps and summated to make volume-based data of the entire tumor. Histogram parameters (mean ADC, kurtosis, and skewness) were correlated with treatment response using unpaired Student t test. Univariate and multivariate analysis of the ADC parameters, patient age, sex, whole tumor volume, and T stage were also performed to predict tumor response to induction chemotherapy.Results: Response to induction chemotherapy was good in 13 of the 25 patients and poor in 12. The mean ADC values of good responders at standard b-value (ADC 1000 ), 1.23 « 0.34 (© 10 ¹3 mm 2 /s), and high b-value (ADC 2000 ), 0.62 « 0.14 (© 10 ¹3 mm 2 /s), were lower than those of poor responders (ADC 1000 , 1.32 « 0.28 [© 10 ¹3 mm 2 /s]; ADC 2000 , 0.76 « 0.15 [© 10 ¹3 mm 2 /s]), but significant difference was achieved only at the ADC 2000 map (P = 0.02). In addition, mean tumor volume prior to treatment of good responders was smaller than that of poor responders. However, at multiple logistic regression analysis, only the mean ADC 2000 value remained as a significant predictor of response to induction chemotherapy.Conclusion: DWI with high b-values (b = 0 and 2,000 s/mm 2 ) as an assessment of ADC values may help predict tumor response to neoadjuvant chemotherapy for primary HNSCCs.

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Economic burden of heart failure: A summary of recent literature

Cited by 153 publications

References 54 publications

A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home‐HF study

A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home‐HF study

The prognostic influence of chronic obstructive pulmonary disease in patients hospitalised for chronic heart failure

Squamous Cell Carcinoma of the Head and Neck: Comparison of Diffusion-weighted MRI at b-values of 1,000 and 2,000 s/mm<sup>2</sup> to Predict Response to Induction Chemotherapy

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