Economic burden of prescriptive inadequacy in the management of osteoarthritis in Italy

Basile, Michele; Rumi, Filippo; Palmeri, Marco; Mattozzi, Ivano; Manzoli, Lamberto; Mammuccari, Massimo; Gigliotti, S.; Bernabei, Roberto; Cicchetti, Americo

doi:10.33393/grhta.2020.2130

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The economic impact of mesotherapy appears to be significant. 36 Ad hoc studies should be designed to measure the impact of drug-sparing effects and avoided drug interactions on economic resources. Treatment algorithms that include mesotherapy could also be evaluated to assess the impact on individual patient care pathways.…”

Section: Health Technology Assessmentmentioning

confidence: 99%

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A Call to Action by the Italian Mesotherapy Society on Scientific Research

Mammucari¹,

Paolucci²,

Russo³

et al. 2021

DDDT

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Mesotherapy (local intradermal therapy, LIT) is a technique used to slowly spread drugs in tissues underlying the site of injection to prolong the pharmacological effect with respect to intramuscular injection. Recommendations for proper medical use of this technique have been made for pain medicine and rehabilitation, chronic venous disease, sport medicine, musculoskeletal disorders, several dermatological conditions, skin ageing, and immune-prophylaxis. Although mesotherapy is considered a valid technique, unresolved questions remain, which should be answered to standardize methodology and dosing regimen as well as to define the right indications in clinical practice. New randomized controlled trials are needed to test single products (dose, frequency of administration, efficacy and safety). Even infiltration of substances for dermo-cosmetic purposes must be guided by safety and efficacy tests before being proposed by mesotherapy. In this article, we put forth a preclinical and clinical research plan and a health technology assessment as a call to action by doctors, researchers and scientific societies to aid national health authorities in considering mesotherapy for prevention, treatment and rehabilitation paths.

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Section: Health Technology Assessmentmentioning

confidence: 99%

“…Treatment algorithms that include mesotherapy could also be evaluated to assess the impact on individual patient care pathways. In fact, existing literature suggests that application of mesotherapy according to good clinical practice 36 seems to be able to satisfy all stakeholders involved.…”

Section: Health Technology Assessmentmentioning

confidence: 99%

A Call to Action by the Italian Mesotherapy Society on Scientific Research

Mammucari¹,

Paolucci²,

Russo³

et al. 2021

DDDT

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“…The healthcare burden related to OA is growing and in many developed countries is considered unsustainable. For example in Spain and Italy-two of the countries with the longest life expectancy in Europe-the average annual cost for OA medications per patient was estimated between €1000 and 1500 per year [5,6]. Globally costs take on an even more impressive aspect.…”

Section: Introductionmentioning

confidence: 99%

Effects of Patient Education on Pain and Function and Its Impact on Conservative Treatment in Elderly Patients with Pain Related to Hip and Knee Osteoarthritis: A Systematic Review

Sinatti

Romero

Martínez-Pozas

et al. 2022

IJERPH

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(1) Background: Patient education (PE), exercise therapy, and weight management are recommended as first-line interventions for hip and knee osteoarthritis (OA). Evidence supporting the effectiveness of exercise therapy and weight management in people with lower-limb OA has been synthesized in recent studies. However, according to the Osteoarthritis Research Society International, PE is often considered a standard of care and the inclusion of this as a first-line intervention for people with knee OA in clinical practice guidelines is often supported by limited evidence. The aim of this review is to evaluate the effects of PE on pain and function and how it impacts on conservative treatment. (2) Methods: This is a literature review of studies investigating the effect of patient education on pain and function and its impact on conservative treatment in elderly patients with pain related to hip and knee OA. PRISMA guidelines were followed during the design, search, and reporting stages of this review. The search was carried out in the PubMed database. (3) Results: A total of 1732 studies were detected and analyzed by performing the proposed searches in the detailed databases. After removing duplicates and analyzing the titles and abstracts of the remaining articles, 20 studies were ultimately selected for this review. Nineteen of these twenty articles showed positive results in pain or function in patients with pain related to hip and knee OA. (4) Conclusions: PE seems to be effective in reducing pain and improving function in patients with pain related to hip and knee OA. Furthermore patient education seems to positively impact the conservative treatment with which it can be associated.

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Impact of Health Education Programme on Adherence to Treatment in Knee Osteoarthritis: An Interventional Study on Egyptian Patients

Ebaid,

Mortada,

Abd‐Ghani

et al. 2024

Musculoskeletal Care

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AimTo measure the level of adherence of patients with primary knee osteoarthritis (KOA) to an interventional therapeutic and rehabilitation programme and investigate factors that hinder patients' adherence.MethodsA total of 154 participants with primary knee osteoarthritis (KOA) were divided into intervention and control groups. The intervention protocol included patient education on the nature and treatment of KOA, therapeutic exercise, a weight loss programme for overweight patients, and a physical therapy programme. Participants were followed for 3 months. The Visual Analog Scale for Pain (VAS‐p), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and knee Kellgren‐Lawrence OA grading were measured before and after the intervention. Additionally, the Morisky adherence questionnaire and the WHO Multidimensional Framework for factors affecting adherence were assessed.ResultsOne fifty four participants with KOA were randomly allocated into intervention and control groups. A low level of adherence was detected in both groups (68.8% in the intervention group vs. 84.4% in the control group). Patients who followed the interventional programme were more adherent. Adherence to therapy was associated with a reduction in the Visual Analog Scale for Pain (VAS‐p) (p = 0.016) and improved function as measured by WOMAC (p = 0.018). Factors primarily associated with patient non‐adherence included unemployment (67.8%), low income (59.3%), no previous response to therapy (58.5%), less frequent follow‐up visits (55.1%), lack of insurance (66.9%), difficult access to services (59.3%), and high cost of services (55.1%).ConclusionAdherence to treatment in OA patients is a significant concern and a common problem, appearing to be associated more with socioeconomic factors than with pain and function.

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Economic burden of prescriptive inadequacy in the management of osteoarthritis in Italy

Cited by 3 publications

References 11 publications

A Call to Action by the Italian Mesotherapy Society on Scientific Research

A Call to Action by the Italian Mesotherapy Society on Scientific Research

Effects of Patient Education on Pain and Function and Its Impact on Conservative Treatment in Elderly Patients with Pain Related to Hip and Knee Osteoarthritis: A Systematic Review

Impact of Health Education Programme on Adherence to Treatment in Knee Osteoarthritis: An Interventional Study on Egyptian Patients

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