Economic burden of stroke: a systematic review on post-stroke care

Bukumirić, Zoran; Gothe, Holger; Borba, Helena Hiemisch Lobo; Sroczynski, Gaby; Vujičić, Jelena; Toell, Thomas; Siebert, Uwe

doi:10.1007/s10198-018-0984-0

Cited by 362 publications

(272 citation statements)

References 67 publications

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“…Stroke is the third most common cause of disability globally, with incidence remaining high in New Zealand (Valery, Bo, & George, 2017). Stroke has an impact on an individual's ability to carry out activities of daily living and participate in life roles, and this places a burden on health and social care (Rajsic et al, 2019). Self-management is a concept that has received increased attention in stroke rehabilitation, encouraging individuals to take charge of and become independent in managing their lives following stroke (Jones, Riazi, & Norris, 2013).…”

Section: Introductionmentioning

confidence: 99%

Attitudes of healthcare professionals towards self-management for patients with stroke

Taylor¹,

Monsanto²

2019

NZJP

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Self-management approaches towards stroke rehabilitation are gaining more attention due to emerging evidence of their impact on patient outcomes. This mixed methods study explored the attitudes of healthcare professionals (HCPs) towards stroke selfmanagement. The Bridges Stroke Self-Management Programme (Bridges SSMP) training was delivered to 51 HCPs in New Zealand. Questionnaires were completed by consenting participants (n=43) prior to administration of the Bridges SSMP training. In-depth, semi-structured interviews were conducted with three participants. The General Inductive Approach was used for thematic analysis of the qualitative data. The resulting overarching theme was "integrating the self-management concept into practice", which encompasses organisational, contextual and individual factors that HCPs feel are challenges when applying self-management. Two contributors to this theme -"education" and "facilitating empowerment" -emerged as barriers or enablers, respectively, to putting self-management into practice. Questionnaire data showed HCPs were confident in their capability of self-management concepts yet did not frequently use them in practice. Healthcare professionals were mostly positive about the concept of self-management but challenges and barriers were evident when applying this to practice. Hence, they may require a deeper understanding of the principles of self-management and become more familiar with the process by applying the principles of self-management in their own lives.Taylor, A., Monsanto, X., Kilgour, H., Smith, C., & Hale, L. (2019). Attitudes of healthcare professionals towards selfmanagement for patients with stroke.

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Section: Introductionmentioning

confidence: 99%

Attitudes of healthcare professionals towards self-management for patients with stroke

Taylor¹,

Monsanto²

2019

NZJP

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“…Stroke was the second most frequent cause of death and the third most frequent cause of disability worldwide. In a recent systematic review, post‐stroke care costs per patient month were estimated to range from $752 in Australia to $4850 in the USA, underlining the substantial overall economic burden associated with this neurological condition . Altogether, these findings clearly demonstrate the importance of better stroke prevention in the future.…”

Section: Introductionmentioning

confidence: 99%

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Jacob

Tanislav

Kostev³

2019

Euro J of Neurology

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Background and purpose Little is known about the long‐term association between transient ischaemic attack (TIA) and stroke. Therefore, the goal of this study was to analyze the long‐term risk of stroke and associated predictors in a large cohort of TIA patients followed in general practices in Germany. Methods This study included patients with an initial TIA diagnosis and subsequently followed up in one of 1262 general practices in Germany between January 2007 and December 2016 (N = 19 824 patients). The primary outcome of the study was the risk of ischaemic stroke within 10 years of the initial diagnosis of TIA. The secondary outcome was the identification of demographic, clinical and pharmaceutical variables significantly associated with stroke in TIA patients. Results Within 10 years of the initial TIA diagnosis, 18.3% of individuals were diagnosed with stroke. Age was positively associated with stroke, with hazard ratios ranging from 1.88 in patients aged 51–60 years to 4.00 in those aged >80 years (reference group: patients aged ≤50 years). Furthermore, male sex, hypertension, diabetes mellitus, atrial fibrillation and ischaemic heart diseases had an additional impact on the risk of stroke. Finally, new oral anticoagulants, heparins, diuretics, angiotensin II receptor blockers and platelet aggregation inhibitors were identified as protective factors. Conclusions In a cohort of almost 20 000 TIA patients, 18.3% were diagnosed with stroke within 10 years after the TIA index event. Several demographic, clinical and pharmaceutical variables significantly predicted the long‐term risk of stroke in TIA patients.

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“…Results from the 2015 iteration of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) showed that although the age-standardised death rates and prevalence of stroke have decreased over time, the overall burden of stroke has remained high. The results provided here are the most up-to-date estimates of death, prevalence, incidence, and disability for overall stroke and the pathological types of ischaemic and haemorrhagic stroke [14,15].…”

Section: Discussionmentioning

confidence: 97%

Protective Action of Betulinic Acid on Cerebral Ischemia/Reperfusion Injury through Inflammation and Energy Metabolic Homeostasis

Jiang

Hao

2020

Applied Sciences

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This work evaluated the protective effects of betulinic acid (BA) in vitro cerebral ischemia/reperfusion and provides clues about its pharmacological mechanism. A rat model of middle cerebral artery occlusion (MCAO) was established to investigate the effects of BA on cerebral ischemia. SHSY5Y cell injury was induced by oxygen–glucose deprivation and recovery (OGD/R) to further verify the action of BA in vitro. Our data show a significant improvement in infarct size, neurological score, and cerebral edema after BA treatment. Enzyme linked immunosorbent assay (ELISA) data show that BA inhibited interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in vivo and in vitro. Protein expression results show that BA down-regulated hypoxia-inducible factor-1α (HIF-1α), up-regulated adenosine monophosphate activated protein kinase (AMPK), peroxisome proliferative activated receptor (PPAR)-α, and PPAR-γ coactivator-1α (PGC-1α), and blocked phosphorylation of IκBα and nuclear factor kappa Bp65 (NF-κB-p65) in the brains of MCAO rats and OGD/R-stimulated SHSY5Y cells. The results reveal the potent effects of BA on cerebral ischemia, suggesting that HIF-1α might be a crucial therapeutic target to regulate energy metabolism and inflammation.

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Economic burden of stroke: a systematic review on post-stroke care

Cited by 362 publications

References 67 publications

Attitudes of healthcare professionals towards self-management for patients with stroke

Attitudes of healthcare professionals towards self-management for patients with stroke

Long‐term risk of stroke and its predictors in transient ischaemic attack patients in Germany

Protective Action of Betulinic Acid on Cerebral Ischemia/Reperfusion Injury through Inflammation and Energy Metabolic Homeostasis

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