Economic comparison of hemostatic agents in cardiac surgery

Sugarman, Rebecca; Tackett, S.; Li-McLeod, Josephine; Kreuwel, Huub T. C.; Alvarez, Piedad; Nasso, Giuseppe

doi:10.1016/j.jval.2013.03.1470

Cited by 1 publication

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“…Three studies identified in this review investigated the clinical and economic value of Floseal ® in cardiac and vascular procedures [ 6 – 8 ] (Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…The third study was an abstract accepted for poster publication at the International Society For Pharmacoeconomics and Outcomes Research in May 2013 [ 8 ] that assessed the economic value of Floseal ® in the US based on the study endpoints and results of the Nasso study [ 7 ] and quantified the monetary costs associated with the efficient control of intraoperative bleeding and contributing complications. If FloSeal ® was the exclusive method used to achieve haemostasis in a hospital performing 600 mixed cardiac surgeries annually, outcomes would be improved and achieved cost savings due to the 242 hours saved in operating room and 33 major and 76 minor complications.…”

Section: Resultsmentioning

confidence: 99%

“…Just only one study included in this review, evaluated the economic value of Floseal ® [ 8 ], concretely in cardiac surgery. Regarding thyroid surgery, the authors suggested that the costs associated with Floseal ® therapy are likely to be offset by a shorter postoperative stay and reduced time in the operating theatre [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fifteen of the 26 clinical evaluations considered in this review (with the exception of an economic study [ 8 ]) included 50 patients or more, and 12 of the studies had sample sizes of less than 50 patients. Considering the studies with <50 patients, 66.6% (8) of the results obtained were not significantly better for Floseal ® , and the remaining 33.4% (4) were significantly better.…”

Section: Discussionmentioning

confidence: 99%

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BackgroundSurgical bleeding can be associated with an increased risk of morbidity and mortality across all surgical areas. Thus, numerous products have been developed to achieve haemostasis. A flowable haemostatic matrix such as Floseal® can quickly and reliably stop bleeding across the full spectrum of bleeding scenarios. The aim of this study was to systematically review clinical and economic evidence regarding the use of Floseal® in surgical procedures.MethodsAn extensive literature search was conducted in PubMed, EMBASE, and the Cochrane Library over the period spanning 2003–2013 to identify publications related to Floseal® use in all types of surgical procedures. Case reports and case series studies were excluded.ResultsA total of 27 papers met the selection criteria and were analysed. In the studies, blood loss and the time to achieve haemostasis were the most reported outcomes used to assess the efficacy of Floseal®. The majority of published studies (64%) examined the use of Floseal® compared with conventional methods (such as electrocautery or suturing). The remaining 36% of the studies evaluated the use of Floseal® compared with other haemostatic agents, such as Surgicel®, Gelfoam®, and Hemostase®. FloSeal® has been demonstrated to be an efficacious method in surgical procedures to reduce the time to achieve haemostasis, the frequency of intra- and postoperative bleeding, and the length of hospital stay, among other primary outcomes, resulting in less consumption of health resources.ConclusionsThe majority of the selected studies confirmed that Floseal® showed improvements over other haemostatic agents in achieving haemostasis and reducing blood loss.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2482-14-111) contains supplementary material, which is available to authorized users.

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“…Three studies identified in this review investigated the clinical and economic value of Floseal ® in cardiac and vascular procedures [ 6 – 8 ] (Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%